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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   A molecular mechanism that links Hippo signalling to the inhibition of Wnt/beta-catenin signalling [作者：Imajo, M; Miyatake, K; Iimura, A; Miyamoto, A; Nishida, E,期刊：EMBO journal, 页码：1109-1122 , 文章类型： Article，,卷期：2012年31-5] The Hippo signalling pathway has emerged as a key regulator of organ size, tissue homeostasis, and patterning. Recent studies have shown that two effectors in this pathway, YAP/TAZ, modulate Wnt/beta-catenin signalling t... STIM1 is required for attenuation of PMCA-mediated Ca2+ clearance during T-cell activation [作者：Ritchie, MF; Samakai, E; Soboloff, J,期刊：EMBO journal, 页码：1123-1133 , 文章类型： Article，,卷期：2012年31-5] T-cell activation involves a complex signalling cascade uniquely dependent on elevated cytosolic Ca2+ levels. Further, the spatiotemporal characteristics of this Ca2+ signal play a critical role in this process via selec... Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis [作者：Nogueira, V; Sundararajan, D; Kwan, JM; Peng, XD; Sarvepalli, N; Sonenberg, N; Hay, N,期刊：EMBO journal, 页码：1134-1146 , 文章类型： Article，,卷期：2012年31-5] The requirement of Akt for cell proliferation and oncogenesis is mammalian target of rapamycin complex 1 (mTORC1) dependent. SV40 large T expression in Akt-deficient cells restores cell proliferation rate, but is insuffi... Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice [作者：Song, H; Kim, H; Lee, K; Lee, DH; Kim, TS; Song, JY; Lee, D; Choi, D; Ko, CY; Kim, HS; Shin, HI; Choi, J; Park, H; Park, C; Jeong, D; Lim, DS,期刊：EMBO journal, 页码：1147-1159 , 文章类型： Article，,卷期：2012年31-5] RASSF2 belongs to the Ras-association domain family (RASSF) of proteins, which may be involved in the Hippo signalling pathway. However, the role of RASSF2 in vivo is unknown. Here, we show that Rassf2 knockout mice mani... APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer [作者：Brough, R; Bajrami, I; Vatcheva, R; Natrajan, R; Reis, JS; Lord, CJ; Ashworth, A,期刊：EMBO journal, 页码：1160-1176 , 文章类型： Article，,卷期：2012年31-5] Mutations in BRCA2 confer an increased risk of cancer development, at least in part because the BRCA2 protein is required for the maintenance of genomic integrity. Here, we use proteomic profiling to identify APRIN (PDS5... ATR maintains select progenitors during nervous system development [作者：Lee, Y; Shull, ERP; Frappart, PO; Katyal, S; Enriquez-Rios, V; Zhao, JF; Russell, HR; Brown, EJ; McKinnon, PJ,期刊：EMBO journal, 页码：1177-1189 , 文章类型： Article，,卷期：2012年31-5] The ATR (ATM (ataxia telangiectasia mutated) and rad3-related) checkpoint kinase is considered critical for signalling DNA replication stress and its dysfunction can lead to the neurodevelopmental disorder, ATR-Seckel sy... RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex [作者：Hirai, S; Miwa, A; Ohtaka-Maruyama, C; Kasai, M; Okabe, S; Hata, Y; Okado, H,期刊：EMBO journal, 页码：1190-1202 , 文章类型： Article，,卷期：2012年31-5] Appropriate number of neurons and glial cells is generated from neural stem cells (NSCs) by the regulation of cell cycle exit and subsequent differentiation. Although the regulatory mechanism remains obscure, Id (inhibit...