- Arginine methylation controls growth regulation by E2F-1
[作者:Cho, EC; Zheng, SS; Munro, S; Liu, G; Carr, SM; Moehlenbrink, J; Lu, YC; Stimson, L; Khan, O; Konietzny, R; McGouran, J; Coutts, AS; Kessler, B; Kerr, DJ; La Thangue, NB,期刊:EMBO journal, 页码:1785-1797 , 文章类型: Article,,卷期:2012年31-7]
- E2F transcription factors are implicated in diverse cellular functions. The founding member, E2F-1, is endowed with contradictory activities, being able to promote cell-cycle progression and induce apoptosis. However, th...
- DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1
[作者:Travesa, A; Kuo, D; de Bruin, RAM; Kalashnikova, TI; Guaderrama, M; Thai, K; Aslanian, A; Smolka, MB; Yates, JR; Ideker, T; Wittenberg, C,期刊:EMBO journal, 页码:1811-1822 , 文章类型: Article,,卷期:2012年31-7]
- MBF and SBF transcription factors regulate a large family of coordinately expressed G1/S genes required for early cell-cycle functions including DNA replication and repair. SBF is inactivated upon S-phase entry by Clb/CD...
- Palmitoylated calnexin is a key component of the ribosome-translocon complex
[作者:Lakkaraju, AKK; Abrami, L; Lemmin, T; Blaskovic, S; Kunz, B; Kihara, A; Dal Peraro, M; van der Goot, FG,期刊:EMBO journal, 页码:1823-1835 , 文章类型: Article,,卷期:2012年31-7]
- A third of the human genome encodes N-glycosylated proteins. These are co-translationally translocated into the lumen/membrane of the endoplasmic reticulum (ER) where they fold and assemble before they are transported to...
- Structural insights into initial and intermediate steps of the ribosome-recycling process
[作者:Yokoyama, T; Shaikh, TR; Iwakura, N; Kaji, H; Kaji, A; Agrawal, RK,期刊:EMBO journal, 页码:1836-1846 , 文章类型: Article,,卷期:2012年31-7]
- The ribosome-recycling factor (RRF) and elongation factor-G (EF-G) disassemble the 70S post-termination complex (PoTC) into mRNA, tRNA, and two ribosomal sub-units. We have determined cryo-electron microscopic structures...
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