- Genetic Variations in Epigenetic Genes Are Predictors of Recurrence in Stage I or II Non-Small Cell Lung Cancer Patients
[作者：Wagner, KW; Ye, YQ; Lin, J; Vaporciyan, AA; Roth, JA; Wu, XF,期刊：Clinical Cancer Research, 页码：585-592 , 文章类型： Article，,卷期：2012年18-2]
- Purpose: Early-stage non-small cell lung cancer (NSCLC) is potentially curable, however, many patients develop recurrent disease. Therefore, identification of biomarkers that can be used to predict patient's risk of recu...
- BAP1tism of a Tumor Suppressor
[作者：Woodman, SE,期刊：Clinical Cancer Research, 页码：323-325 , 文章类型： Editorial Material，,卷期：2012年18-2]
- Driving cancer cells into a more differentiated state is a rational therapeutic approach. Primary uveal melanoma cells with a propensity to metastasize have less-differentiated features than their less aggressive counter...
- New Challenges in Endpoints for Drug Development in Advanced Melanoma
[作者：Ribas, A; Hersey, P; Middleton, MR; Gogas, H; Flaherty, KT; Sondak, VK; Kirkwood, JM,期刊：Clinical Cancer Research, 页码：336-341 , 文章类型： Article，,卷期：2012年18-2]
- During the past 3 decades, the field of clinical research for the treatment of advanced melanoma lacked significant advances. Available drugs had low antitumor activity and no proven benefit in overall survival. Recently...
- Multiple Myeloma Mesenchymal Stem Cells: Characterization, Origin, and Tumor-Promoting Effects
[作者：Reagan, MR; Ghobrial, IM,期刊：Clinical Cancer Research, 页码：342-349 , 文章类型： Review，,卷期：2012年18-2]
- Hematologic malignancies rely heavily on support from host cells through a number of well-documented mechanisms. Host cells, specifically mesenchymal stem cells (MSC), support tumor cell growth, metastasis, survival, bon...
- Molecular Analysis of Colorectal Tumors within a Diverse Patient Cohort at a Single Institution
[作者：Sylvester, BE; Huo, DZ; Khramtsov, A; Zhang, J; Smalling, RV; Olugbile, S; Polite, BN; Olopade, OI,期刊：Clinical Cancer Research, 页码：350-359 , 文章类型： Article，,卷期：2012年18-2]
- Purpose: African American colorectal cancer patients have worse survival outcomes than Caucasian patients. To determine whether differences exist in the molecular mechanisms driving colorectal cancer between African Amer...
- A Noncanonical Flt3ITD/NF-kappa B Signaling Pathway Represses DAPK1 in Acute Myeloid Leukemia
[作者：Shanmugam, R; Gade, P; Wilson-Weekes, A; Sayar, H; Suvannasankha, A; Goswami, C; Li, L; Gupta, S; Cardoso, AA; Al Baghdadi, T; Sargent, KJ; Cripe, LD; Kalvakolanu, DV; Boswell, HS,期刊：Clinical Cancer Research, 页码：360-369 , 文章类型： Article，,卷期：2012年18-2]
- Purpose: Death-associated protein kinase 1 (DAPK1), a tumor suppressor, is a rate-limiting effector in an endoplasmic reticulum (ER) stress-dependent apoptotic pathway. Its expression is epigenetically suppressed in seve...
- Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome
[作者：Lazova, R; Camp, RL; Klump, V; Siddiqui, SF; Amaravadi, RK; Pawelek, JM,期刊：Clinical Cancer Research, 页码：370-379 , 文章类型： Article，,卷期：2012年18-2]
- Purpose: Measurement of autophagy in cancer and correlation with histopathologic grading or clinical outcomes has been limited. Accordingly, we investigated LC3B as an autophagosome marker by analyzing nearly 1,400 tumor...
- Ran Is a Potential Therapeutic Target for Cancer Cells with Molecular Changes Associated with Activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK Pathways
[作者：Yuen, HF; Chan, KK; Grills, C; Murray, JT; Platt-Higgins, A; Eldin, OS; O'Byrne, K; Janne, P; Fennell, DA; Johnston, PG; Rudland, PS; El-Tanani, M,期刊：Clinical Cancer Research, 页码：380-391 , 文章类型： Article，,卷期：2012年18-2]
- Purpose: Cancer cells have been shown to be more susceptible to Ran knockdown than normal cells. We nowinvestigate whether Ran is a potential therapeutic target of cancers with frequently found mutations that lead to hig...
- Serum Interleukin-6, Insulin, and HOMA-IR in Male Individuals with Colorectal Adenoma
[作者：Sasaki, Y; Takeda, H; Sato, T; Orii, T; Nishise, S; Nagino, K; Iwano, D; Yaoita, T; Yoshizawa, K; Saito, H; Tanaka, Y; Kawata, S,期刊：Clinical Cancer Research, 页码：392-399 , 文章类型： Article，,卷期：2012年18-2]
- Purpose: It is widely acknowledged that chronic low-grade inflammation plays a key role in the development of obesity-related insulin resistance and type 2 diabetes. The level of circulating interleukin-6 (IL-6), one of ...
- Lifetime Cancer Risks in Individuals with Germline PTEN Mutations
[作者：Tan, MH; Mester, JL; Ngeow, J; Rybicki, LA; Orloff, MS; Eng, C,期刊：Clinical Cancer Research, 页码：400-407 , 文章类型： Article，,卷期：2012年18-2]
- Purpose: Age-adjusted cancer incidence and age-related penetrance studies have helped guide cancer risk assessment and management. PTEN hamartoma tumor syndrome (PHTS) is a term encompassing subsets of several clinical s...
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