- Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803
[作者:Ogino, S; Shima, K; Meyerhardt, JA; McCleary, NJ; Ng, K; Hollis, D; Saltz, LB; Mayer, RJ; Schaefer, P; Whittom, R; Hantel, A; Benson, AB; Spiegelman, D; Goldberg, RM; Bertagnolli, MM; Fuchs, CS,期刊:Clinical Cancer Research, 页码:890-900 , 文章类型: Article,,卷期:2012年18-3]
- Purpose: Alterations in the RAS-RAF-MAP2K (MEK)-MAPK signaling pathway are major drivers in colorectal carcinogenesis. In colorectal cancer, BRAF mutation is associated with microsatellite instability (MSI), and typicall...
- Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness
[作者:Chimge, NO; Baniwal, SK; Luo, JQ; Coetzee, S; Khalid, O; Berman, BP; Tripathy, D; Ellis, MJ; Frenkel, B,期刊:Clinical Cancer Research, 页码:901-911 , 文章类型: Article,,卷期:2012年18-3]
- Purpose: To assess the clinical significance of the interaction between estrogen and Runx2 signaling, previously shown in vitro. Experimental Design: MCF7/Rx2(dox) breast cancer cells were treated with estradiol and/or d...
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