- Inhibition of Collagen Receptor Discoidin Domain Receptor-1 (DDR1) Reduces Cell Survival, Homing, and Colonization in Lung Cancer Bone Metastasis
[作者：Valencia, K; Ormazabal, C; Zandueta, C; Luis-Ravelo, D; Anton, I; Pajares, MJ; Agorreta, J; Montuenga, LM; Martinez-Canarias, S; Leitinger, B; Lecanda, F,期刊：Clinical Cancer Research, 页码：969-980 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: We investigated the role of the collagen-binding receptor discoidin domain receptor-1 (DDR1) in the initiation and development of bone metastasis. Experimental Design: We conducted immunohistochemical analyses i...
- Changes in Keratin Expression during Metastatic Progression of Breast Cancer: Impact on the Detection of Circulating Tumor Cells
[作者：Joosse, SA; Hannemann, J; Spotter, J; Bauche, A; Andreas, A; Muller, V; Pantel, K,期刊：Clinical Cancer Research, 页码：993-1003 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: Circulating tumor cells (CTC) might function as early markers for breast cancer metastasis or monitoring therapy efficacy. Enrichment and identification of CTCs are based on epithelial markers that might be modu...
- Characterization and Clinical Evaluation of CD10(+) Stroma Cells in the Breast Cancer Microenvironment
[作者：Desmedt, C; Majjaj, S; Kheddoumi, N; Singhal, SK; Haibe-Kains, B; El Ouriaghli, F; Chaboteaux, C; Michiels, S; Lallemand, F; Journe, F; Duvillier, H; Loi, S; Quackenbush, J; Dekoninck, S; Blanpain, C; Lagneaux, L; Houhou, N; Delorenzi, M; Larsimont, D; Piccart, M; Sotiriou, C,期刊：Clinical Cancer Research, 页码：1004-1014 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: There is growing evidence that interaction between stromal and tumor cells is pivotal in breast cancer progression and response to therapy. Based on earlier research suggesting that during breast cancer progress...
- PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy
[作者：Fraser, M; Zhao, H; Luoto, KR; Lundin, C; Coackley, C; Chan, N; Joshua, AM; Bismar, TA; Evans, A; Helleday, T; Bristow, RG,期刊：Clinical Cancer Research, 页码：1015-1027 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: PTEN deletions in prostate cancer are associated with tumor aggression and poor outcome. Recent studies have implicated PTEN as a determinant of homologous recombination (HR) through defective RAD51 function. Si...
- New Gene-Immunotherapy Combining TRAIL-Lymphocytes and EpCAMxCD3 Bispecific Antibody for Tumor Targeting
[作者：Groth, A; Salnikov, AV; Ottinger, S; Gladkich, J; Liu, L; Kallifatidis, G; Salnikova, O; Ryschich, E; Giese, N; Giese, T; Momburg, F; Buchler, MW; Moldenhauer, G; Herr, I,期刊：Clinical Cancer Research, 页码：1028-1038 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: To enhance T-cell responsiveness toward cancer cells, we overexpressed TRAIL in lymphocytes, as this death ligand induces tumor-specific apoptosis. To increase contact time of lymphocytes with tumor cells and th...
- Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS-Mutant Colorectal Cancer Models
[作者：Morelli, MP; Tentler, JJ; Kulikowski, GN; Tan, AC; Bradshaw-Pierce, EL; Pitts, TM; Brown, AM; Nallapareddy, S; Arcaroli, JJ; Serkova, NJ; Hidalgo, M; Ciardiello, F; Eckhardt, SG,期刊：Clinical Cancer Research, 页码：1051-1062 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: Despite the availability of several active combination regimens for advanced colorectal cancer (CRC), the 5-year survival rate remains poor at less than 10%, supporting the development of novel therapeutic appro...
- Evaluation of Deuterated F-18- and C-11-Labeled Choline Analogs for Cancer Detection by Positron Emission Tomography
[作者：Witney, TH; Alam, IS; Turton, DR; Smith, G; Carroll, L; Brickute, D; Twyman, FJ; Nguyen, QD; Tomasi, G; Awais, RO; Aboagye, EO,期刊：Clinical Cancer Research, 页码：1063-1072 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: C-11-Choline-positron emission tomography (PET) has been exploited to detect the aberrant choline metabolism in tumors. Radiolabeled choline uptake within the imaging time is primarily a function of transport, p...
- Optical Imaging with Her2-Targeted Affibody Molecules Can Monitor Hsp90 Treatment Response in a Breast Cancer Xenograft Mouse Model
[作者：van de Ven, SMWY; Elias, SG; Chan, CT; Miao, Z; Cheng, Z; De, A; Gambhir, SS,期刊：Clinical Cancer Research, 页码：1073-1081 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: To determine whether optical imaging can be used for in vivo therapy response monitoring as an alternative to radionuclide techniques. For this, we evaluated the known Her2 response to 17-dimethylaminoethylamino...
- Detection of TIMP3 Promoter Hypermethylation in Salivary Rinse as an Independent Predictor of Local Recurrence-Free Survival in Head and Neck Cancer
[作者：Sun, WY; Zaboli, D; Wang, H; Liu, Y; Arnaoutakis, D; Khan, T; Khan, Z; Koch, WM; Califano, JA,期刊：Clinical Cancer Research, 页码：1082-1091 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: To validate a panel of methylation-based salivary rinse biomarkers(P16, CCNA1, DCC, TIMP3, MGMT, DAPK, and MINT31) previously shown to be independently associated with poor overall survival and local recurrence ...
- Phase I Study of Bosutinib, a Src/Abl Tyrosine Kinase Inhibitor, Administered to Patients with Advanced Solid Tumors
[作者：Daud, AI; Krishnamurthi, SS; Saleh, MN; Gitlitz, BJ; Borad, MJ; Gold, PJ; Chiorean, EG; Springett, GM; Abbas, R; Agarwal, S; Bardy-Bouxin, N; Hsyu, PH; Leip, E; Turnbull, K; Zacharchuk, C; Messersmith, WA,期刊：Clinical Cancer Research, 页码：1092-1100 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: Bosutinib, a potent ATP-competitive, quinolinecarbonitrile Src/Abl kinase inhibitor, was tested in this first-in-human phase I trial in patients with advanced solid tumor malignancies. Patients and Methods: This...
|