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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   Converting Cancer Therapies into Cures: Lessons from Infectious Diseases [作者：Glickman, MS; Sawyers, CL,期刊：Cell, 页码：1089-1098 , 文章类型： Article，,卷期：2012年148-6] During the past decade, cancer drug development has shifted from a focus on cytotoxic chemotherapies to drugs that target specific molecular alterations in tumors. Although these drugs dramatically shrink tumors, the res... Life in the Fast Lane: Mammalian Disease Models in the Genomics Era [作者：Dow, LE; Lowe, SW,期刊：Cell, 页码：1099-1109 , 文章类型： Article，,卷期：2012年148-6] Analyses of the human genome have proven extremely successful in identifying changes that contribute to human disease. Genetically engineered mice provide a powerful tool to analyze these changes, although they are slow ... Reprogramming Cellular Identity for Regenerative Medicine [作者：Cherry, ABC; Daley, GQ,期刊：Cell, 页码：1110-1122 , 文章类型： Article，,卷期：2012年148-6] Although development leads unidirectionally toward more restricted cell fates, recent work in cellular reprogramming has proven that one cellular identity can strikingly convert into another, promising countless applicat... Regulated Noise in the Epigenetic Landscape of Development and Disease [作者：Pujadas, E; Feinberg, AP,期刊：Cell, 页码：1123-1131 , 文章类型： Article，,卷期：2012年148-6] In this Perspective, we synthesize past and present observations in the field of epigenetics to propose a model in which the epigenome can modulate cellular plasticity in development and disease by regulating the effects... Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us? [作者：DeBerardinis, RJ; Thompson, CB,期刊：Cell, 页码：1132-1144 , 文章类型： Review，,卷期：2012年148-6] An understanding of metabolic pathways based solely on biochemistry textbooks would underestimate the pervasive role of metabolism in essentially every aspect of biology. It is evident from recent work that many human di... Mitochondria: In Sickness and in Health [作者：Nunnari, J; Suomalainen, A,期刊：Cell, 页码：1145-1159 , 文章类型： Review，,卷期：2012年148-6] Mitochondria perform diverse yet interconnected functions, producing ATP and many biosynthetic intermediates while also contributing to cellular stress responses such as autophagy and apoptosis. Mitochondria form a dynam... Diabetes Mellitus and the beta Cell: The Last Ten Years [作者：Ashcroft, FM; Rorsman, P,期刊：Cell, 页码：1160-1171 , 文章类型： Review，,卷期：2012年148-6] Diabetes is a major global problem. During the past decade, the genetic basis of various monogenic forms of the disease, and their underlying molecular mechanisms, have been elucidated. Many genes that increase type 2 di...