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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共32条记录   The RNase III enzyme Dicer is essential for germinal center B-cell formation [作者：Xu, SL; Guo, K; Zeng, Q; Huo, JX; Lam, KP,期刊：Blood, 页码：767-776 , 文章类型： Article，,卷期：2012年119-3] MicroRNAs (miRNAs) are short noncoding RNAs that regulate gene expression and are important for pre-B and follicular B lymphopoiesis as demonstrated, respectively, by mb-1-Cre- and cd19-Cre- mediated deletion of Dicer, t... CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules [作者：Kliche, S; Worbs, T; Wang, XQ; Degen, J; Patzak, I; Meineke, B; Togni, M; Moser, M; Reinhold, A; Kiefer, F; Freund, C; Forster, R; Schraven, B,期刊：Blood, 页码：777-785 , 文章类型： Article，,卷期：2012年119-3] The beta 2-integrin lymphocyte function-associated antigen-1 (LFA-1) plays a crucial role within the immune system. It regulates the interaction between T cells and antigen-presenting cells and facilitates T-cell adhesio... HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling [作者：Pan, XY; Rudolph, JM; Abraham, L; Habermann, A; Haller, C; Krijnse-Locker, J; Fackler, OT,期刊：Blood, 页码：786-797 , 文章类型： Article，,卷期：2012年119-3] The Nef protein of HIV-1 facilitates viral replication and disease progression in vivo. Net disturbs the organization of immunological synapses between infected CD4(+) T lymphocytes and antigen-presenting B-lymphocytes t... Nab2 regulates secondary CD8(+) T-cell responses through control of TRAIL expression [作者：Wolkers, MC; Gerlach, C; Arens, R; Janssen, EM; Fitzgerald, P; Schumacher, TN; Medema, JP; Green, DR; Schoenberger, SP,期刊：Blood, 页码：798-804 , 文章类型： Article，,卷期：2012年119-3] CD4(+) Th cells are pivotal for the generation and maintenance of CD8(+) T-cell responses. "Helped" CD8(+) T cells receive signals during priming that prevent the induction of the proapoptotic molecule TNF-related apopto... Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas [作者：Jen, KY; Song, IY; Banta, KL; Wu, D; Mao, JH; Balmain, A,期刊：Blood, 页码：805-809 , 文章类型： Article，,卷期：2012年119-3] T-cell acute lymphoblastic lymphomas commonly demonstrate activating Notch1 mutations as well as mutations or deletions in Fbxw7. However, because Fbxw7 targets Notch1 for degradation, genetic alterations in these genes ... Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH [作者：Yin, L; Kosugi, M; Kufe, D,期刊：Blood, 页码：810-816 , 文章类型： Article，,卷期：2012年119-3] The MUC1-C oncoprotein is aberrantly expressed in most multiple myeloma cells. However, the functional significance of MUC1-C expression in multiple myeloma is not known. The present studies demonstrate that treatment of... Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling [作者：Wey, S; Luo, BQ; Tseng, CC; Ni, M; Zhou, H; Fu, Y; Bhojwani, D; Carroll, WL; Lee, AS,期刊：Blood, 页码：817-825 , 文章类型： Article，,卷期：2012年119-3] Traditionally, GRP78 is regarded as protective against hypoxia and nutrient starvation prevalent in the microenvironment of solid tumors; thus, its role in the development of hematologic malignancies remains to be determ... Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition [作者：Hu, JS; Dang, N; Menu, E; De Bryune, E; Xu, DH; Van Camp, B; Van Valckenborgh, E; Vanderkerken, K,期刊：Blood, 页码：826-837 , 文章类型： Article，,卷期：2012年119-3] Myeloid cell leukemia-1 (Mcl-1) protein is an anti-apoptotic Bcl-2 family protein that plays essential roles in multiple myeloma (MM) survival and drug resistance. In MM, it has been demonstrated that proteasome inhibiti... Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration [作者：Kostyak, JC; Naik, MU; Naik, UP,期刊：Blood, 页码：838-846 , 文章类型： Article，,卷期：2012年119-3] Megakaryocytes are large, polyploid cells that produce platelets. We have previously reported that calcium- and integrin-binding protein 1 (CIB1) regulates endomitosis in Dami cells. To further characterize the role of C... Role and regulation of phosphatidylinositol 3-kinase beta in platelet integrin alpha 2 beta 1 signaling [作者：Consonni, A; Cipolla, L; Guidetti, G; Canobbio, I; Ciraolo, E; Hirsch, E; Falasca, M; Okigaki, M; Balduini, C; Torti, M,期刊：Blood, 页码：847-856 , 文章类型： Article，,卷期：2012年119-3] Integrin alpha 2 beta 1-mediated adhesion of human platelets to monomeric type I collagen or to the GFOGER peptide caused a time-dependent activation of PI3K and Akt phosphorylation. This process was abrogated by pharmac... Regulation of hepcidin expression at high altitude [作者：Talbot, NP; Lakhal, S; Smith, TG; Privat, C; Nickol, AH; Rivera-Ch, M; Leon-Velarde, F; Dorrington, KL; Mole, DR; Robbins, PA,期刊：Blood, 页码：857-860 , 文章类型： Article，,卷期：2012年119-3] Enhanced erythropoietic drive and iron deficiency both influence iron homeostasis through the suppression of the iron regulatory hormone hepcidin. Hypoxia also suppresses hepcidin through a mechanism that is unknown. We ... Vitamin K antagonists in children with heart disease: height and VKORC1 genotype are the main determinants of the warfarin dose requirement [作者：Moreau, C; Bajolle, F; Siguret, V; Lasne, D; Golmard, JL; Elie, C; Beaune, P; Cheurfi, R; Bonnet, D; Loriot, MA,期刊：Blood, 页码：861-867 , 文章类型： Article，,卷期：2012年119-3] Managing vitamin K antagonist (VKA) therapy is challenging in children because of a narrow therapeutic range and wide inter- and intra-individual variability in dose response. Only a few small studies have investigated t... VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children [作者：Biss, TT; Avery, PJ; Brandao, LR; Chalmers, EA; Williams, MD; Grainger, JD; Leathart, JBS; Hanley, JP; Daly, AK; Kamali, F,期刊：Blood, 页码：868-873 , 文章类型： Article，,卷期：2012年119-3] Although genetic and environmental factors explain approximately half of the interindividual variability in warfarin dose requirement in adults, there is limited information available in children. In a cross-sectional st... Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes [作者：Madhusudhan, T; Wang, HJ; Straub, BK; Grone, E; Zhou, QX; Shahzad, K; Muller-Krebs, S; Schwenger, V; Gerlitz, B; Grinnell, BW; Griffin, JH; Reiser, J; Grone, HJ; Esmon, CT; Nawroth, PP; Isermann, B,期刊：Blood, 页码：874-883 , 文章类型： Article，,卷期：2012年119-3] The cytoprotective effects of activated protein C (aPC) are well established. In contrast, the receptors and signaling mechanism through which aPC conveys cytoprotection in various cell types remain incompletely defined.... A novel pathway for human endothelial cell activation by antiphospholipid/anti-beta(2) glycoprotein I antibodies [作者：Allen, KL; Fonseca, FV; Betapudi, V; Willard, B; Zhang, JW; McCrae, KR,期刊：Blood, 页码：884-893 , 文章类型： Article，,卷期：2012年119-3] Antiphospholipid Abs (APLAs) are associated with thrombosis and recurrent fetal loss. These Abs are primarily directed against phospholipid-binding proteins, particularly beta(2)GPI, and activate endothelial cells (ECs) ... The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis [作者：Birdsey, GM; Dryden, NH; Shah, AV; Hannah, R; Hall, MD; Haskard, DO; Parsons, M; Mason, JC; Zvelebil, M; Gottgens, B; Ridley, AJ; Randi, AM,期刊：Blood, 页码：894-903 , 文章类型： Article，,卷期：2012年119-3] The endothelial ETS transcription factor Erg plays an important role in homeostasis and angiogenesis by regulating many endothelial functions including survival and junction stability. Here we show that Erg regulates end...