- Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes
[作者：Sutton, JM; Clark, DE; Dunsdon, SJ; Fenton, G; Fillmore, A; Harris, NV; Higgs, C; Hurley, CA; Krintel, SL; MacKenzie, RE; Duttaroy, A; Gangl, E; Maniara, W; Sedrani, R; Namoto, K; Ostermann, N; Gerhartz, B; Sirockin, F; Trappe, J; Hassiepen, U; Baeschlin, DK,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：1464-1468 , 文章类型： Article，,卷期：2012年22-3]
- Novel deazaxanthine-based DPP-4 inhibitors have been identified that are potent (IC50 < 10 nM) and highly selective versus other dipeptidyl peptidases. Their synthesis and SAR are reported, along with initial efforts to ...
- Synthesis and biological evaluation of deoxy-hematoxylin derivatives as a novel class of anti-HIV-1 agents
[作者：Ishii, H; Koyama, H; Hagiwara, K; Miura, T; Xue, GG; Hashimoto, Y; Kitahara, G; Aida, Y; Suzuki, M,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：1469-1474 , 文章类型： Article，,卷期：2012年22-3]
- SAR studies for the exploration a novel class of anti-human immunodeficiency virus type 1 (HIV-1) agents based on the hematoxylin structure (1) are described. The systematic deoxygenations of 1 including asymmetric synth...
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