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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共71条记录   Recognition of HIV TAR RNA by triazole linked neomycin dimers (vol 21, pg 4788, 2011) [作者：Kumar, S; Arya, DP,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：1827-1829 , 文章类型： Correction，,卷期：2012年22-4] Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists [作者：Henderson, AJ; Guzzo, PR; Ghosh, A; Kaur, J; Koo, JM; Nacro, K; Panduga, S; Pathak, R; Shimpukade, B; Tan, V; Xiang, K; Wierschke, JD; Isherwood, ML,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：1494-1498 , 文章类型： Article，,卷期：2012年22-4] A new series of epiminocyclohepta[b]indoles with potent 5-HT6 antagonist activity were discovered and optimized using in vitro protocols. One compound from this series was progressed to advanced pharmacokinetic (PK) stud... Neomycin-phenolic conjugates: Polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding [作者：Findlay, B; Zhanel, GG; Schweizer, F,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：1499-1503 , 文章类型： Article，,卷期：2012年22-4] Here we present a proof-of-concept study, combining two known antimicrobial agents into a hybrid structure in order to develop an emergent cationic detergent-like interaction with the bacterial membrane. Six amphiphilic ... 4-Phenoxypiperidine pyridazin-3-one histamine H-3 receptor inverse agonists demonstrating potent and robust wake promoting activity [作者：Hudkins, RL; Zulli, AL; Dandu, RR; Tao, M; Josef, KA; Aimone, LD; Haltiwanger, RC; Huang, ZQ; Lyons, JA; Mathiasen, JR; Raddatz, R; Gruner, JA,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：1504-1509 , 文章类型： Article，,卷期：2012年22-4] Structure-activity relationships for a series of phenoxypiperidine pyridazin-3-one H3R antagonists/inverse agonists are disclosed. The search for compounds with improved hERG and DAT selectivity without the formation of ... Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series [作者：Green, OM; McKenzie, AR; Shapiro, AB; Otterbein, L; Ni, HH; Patten, A; Stokes, S; Albert, R; Kawatkar, S; Breed, J,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：1510-1519 , 文章类型： Article，,卷期：2012年22-4] A novel arylsulfonamide-containing series of compounds represented by 1, discovered by highthrough-put screening, inhibit the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-ph... Coomassie blue is sufficient for specific protein detection of aptamer-conjugated chips [作者：Lee, GH; Hah, SS,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：1520-1522 , 文章类型： Article，,卷期：2012年22-4] An aptamer-based biochip for protein detection and quantitation which combines the recent biochip technology and the conventional staining methods, is described. Using a model system comprising His-tagged proteins as the... Dual beta(2)-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD [作者：Shan, WJ; Huang, L; Zhou, Q; Jiang, HL; Luo, ZH; Lai, KF; Li, XS,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：1523-1526 , 文章类型： Article，,卷期：2012年22-4] We designed and synthesized a novel class of dual pharmacology bronchodilators targeting both beta 2-adrenoceptor and PDE4 by applying a multivalent approach. The most potent dual pharmacology molecule, compound 29, poss...