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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共27条记录   Enhanced bioactivity of silybin B methylation products [作者：SYCORDERO ARLENE A; GRAF TYLER N; RUNYON SCOTT P; WANI MANSUKH C; KROLL DAVID J; AGARWAL RAJESH; BRANTLEY SCOTT J; PAINE MARY F; POLYAK STEPHEN J; OBERLIES NICHOLAS H,期刊：Bioorganic & Medicinal Chemistry, 页码：742-747 , 文章类型： Article，,卷期：2013年21-3] Flavonolignans from milk thistle (Silybum marianum) have been investigated for their cellular modulatory properties, including cancer chemoprevention and hepatoprotection, as an extract (silymarin), as partially purified... Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl beta-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1) [作者：FUSHIMI NOBUHIKO; TERANISHI HIROTAKA; SHIMIZU KAZUO; YONEKUBO SHIGERU; OHNO KOHSUKE; MIYAGI TAKASHI; ITOH FUMIAKI; SHIBAZAKI TOSHIHIDE; TOMAE MASAKI; ISHIKAWATAKEMURA YUKIKO; NAKABAYASHI TAKESHI; KAMADA NOBORU; YAMAUCHI YUJI; KOBAYASHI SUSUMU; ISAJI MASAYUKI,期刊：Bioorganic & Medicinal Chemistry, 页码：748-765 , 文章类型： Article，,卷期：2013年21-3] Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose in the gut and is considered a promising target in the development of therapeutic options for postprandial hyperglycemia. Previou... The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists [作者：MATIN AZADEH; DODDAREDDY MUNIKUMAR REDDY; GAVANDE NAVNATH; NAMMI SRINIVAS; GROUNDWATER PAUL W; ROUBIN REBECCA H; HIBBS DAVID E,期刊：Bioorganic & Medicinal Chemistry, 页码：766-778 , 文章类型： Article，,卷期：2013年21-3] Twenty three dual PPAR alpha and gamma molecules of natural product origin, previously reported by our group, were further investigated for pan PPAR transactivation against PPAR delta. The in vitro cell toxicity profile,... Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells [作者：NAKAMURA SEIKOU; NAKASHIMA SOUICHI; TANABE GENZO; ODA YOSHIMI; YOKOTA NAMI; FUJIMOTO KATSUYOSHI; MATSUMOTO TAKAHIRO; SAKUMA RIKA; OHTA TOMOE; OGAWA KEIKO; NISHIDA SHINO; MIKI HISAKO; MATSUDA HISASHI; MURAOKA OSAMU; YOSHIKAWA MASAYUKI,期刊：Bioorganic & Medicinal Chemistry, 页码：779-787 , 文章类型： Article，,卷期：2013年21-3] Methanolic extracts from the flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) were found to show inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From t... Design, synthesis and biological evaluation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents [作者：SONG DOONA; YANG JEE SUN; KIM SEO JOONG; KIM BOKYUNG; PARK SONGKYU; WON MISUN; LEE KIHO; KIM HWAN MOOK; CHOI KANGYELL; LEE KYEONG; HAN GYOONHEE,期刊：Bioorganic & Medicinal Chemistry, 页码：788-794 , 文章类型： Article，,卷期：2013年21-3] RhoB, one of the upstream signaling proteins of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway, is frequently mutated in human cancer. Based on a piperazine alkyl derivative that induced apoptosis via up-regulation... Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity [作者：SCHOLZ THERESE; HEYL CARINA L; BERNARDI DAN; ZIMMERMANN STEFAN; KATTNER LARS; KLEIN CHRISTIAN D,期刊：Bioorganic & Medicinal Chemistry, 页码：795-804 , 文章类型： Article，,卷期：2013年21-3] A di-bromo substituted nitrovinylfuran with reported broad-spectrum antibacterial activity was found to be a potent inhibitor of MurA, a key enzyme in peptidoglycan biosynthesis. Further characterization of the compound ... Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators [作者：GEHRKE SEBASTIAN S; PINTO ERIKA G; STEVERDING DIETMAR; PLEBAN KARIN; TEMPONE ANDRE G; HIDER ROBERT C; WAGNER GERD K,期刊：Bioorganic & Medicinal Chemistry, 页码：805-813 , 文章类型： Article，,卷期：2013年21-3] Iron is an essential growth component in all living organisms and plays a central role in numerous biochemical processes due to its redox potential and high affinity for oxygen. The use of iron chelators has been suggest... Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs [作者：BAECHLER SIMONE A; FEHR MARKUS; HABERMEYER MICHAEL; HOFMANN ANDREAS; MERZ KARLHEINZ; FIEBIG HEINZHERBERT; MARKO DORIS; EISENBRAND GERHARD,期刊：Bioorganic & Medicinal Chemistry, 页码：814-823 , 文章类型： Article，,卷期：2013年21-3] The plant alkaloid lycobetaine has potent topoisomerase-targeting properties and shows anticancer activity. Based on these findings, several lycobetaine analogs were synthesized mainly differing in their substituents at ... Exploration of 1-(3-chloro-4-(4-oxo-4H-chromen-2-yl)phenyl)-3-phenylurea derivatives as selective dual inhibitors of Raf1 and JNK1 kinases for anti-tumor treatment [作者：JIN FENG; GAO DAN; ZHANG CUNLONG; LIU FENG; CHU BIZHU; CHEN YAN; CHEN YU ZONG; TAN CHUNYAN; JIANG YUYANG,期刊：Bioorganic & Medicinal Chemistry, 页码：824-831 , 文章类型： Article，,卷期：2013年21-3] Based on the roles of Raf1 and JNK1 in hepatocarcinoma development, scaffold-based drug design was employed to produce a series of compounds, which subsequently were synthesized and explored as potential dual inhibitors ... Discovery and pharmacological characterization of N [2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2 methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor (vol 19, pg 7221, 2011) [作者：KATO NORIYASU; OKA MITSURU; MURASE TAKAYO; YOSHIDA MASAHIRO; SAKAIRI MASAO; YAMASHITA SATOKO; YASUDA YOSHIKA; YOSHIKAWA AYA; HAYASHI YUUJI; MAKINO MITSUHIRO; TAKEDA MOTOHIRO; MIRENSHA YAKUFU; KAKIGAMI TAKUJI,期刊：Bioorganic & Medicinal Chemistry, 页码：832-833 , 文章类型： Correction，,卷期：2013年21-3] The biology and chemistry of antifungal agents: A review (vol 20, pg 5678, 2012) [作者：KATHIRAVAN MUTHU K; SALAKE AMOL B; CHOTHE APARNA S; DUDHE PRASHIK B; WATODE RAHUL P; MUKTA MAHESHWAR S; GADHWE SANDEEP,期刊：Bioorganic & Medicinal Chemistry, 页码：834-834 , 文章类型： Correction，,卷期：2013年21-3]