- SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene
[作者:Yamashita, S; Ogawa, K; Ikei, T; Udono, M; Fujiki, T; Katakura, Y,期刊:Biochemical and Biophysical Research Communications, 页码:630-634 , 文章类型: Article,,卷期:2012年417-1]
- SIRT1, the mammalian homolog of sirtuins, has emerged as a mediator of the beneficial effects of calorie restriction. Among them, we focused on the SIRT1-induced prevention of cellular senescence, and tried to reveal the...
- Photo-excitation of carotenoids causes cytotoxicity via singlet oxygen production
[作者:Yoshii, H; Yoshii, Y; Asai, T; Furukawa, T; Takaichi, S; Fujibayashi, Y,期刊:Biochemical and Biophysical Research Communications, 页码:640-645 , 文章类型: Article,,卷期:2012年417-1]
- Carotenoids, natural pigments widely distributed in algae and plants, have a conjugated double bond system. Their excitation energies are correlated with conjugation length. We hypothesized that carotenoids whose energy ...
- The stress granule protein Vgl1 and poly(A)-binding protein Pab1 are required for doxorubicin resistance in the fission yeast Schizosaccharomyces pombe
[作者:Morita, T; Satoh, R; Umeda, N; Kita, A; Sugiura, R,期刊:Biochemical and Biophysical Research Communications, 页码:399-403 , 文章类型: Article,,卷期:2012年417-1]
- Doxorubicin is an anthracycline antibiotic widely used for chemotherapy. Although doxorubicin is effective in the treatment of several cancers, including solid tumors and leukemias, the basis of its mechanism of action i...
- A single-step competitive binding assay for mapping of single DNA molecules
[作者:Nyberg, LK; Persson, F; Berg, J; Bergstrom, J; Fransson, E; Olsson, L; Persson, M; Stalnacke, A; Wigenius, J; Tegenfeldt, JO; Westerlund, F,期刊:Biochemical and Biophysical Research Communications, 页码:404-408 , 文章类型: Article,,卷期:2012年417-1]
- Optical mapping of genomic DNA is of relevance for a plethora of applications such as scaffolding for sequencing and detection of structural variations as well as identification cif pathogens like bacteria and viruses. F...
- In vitro selection of Escherichia coli O157:H7-specific RNA aptamer
[作者:Lee, YJ; Han, SR; Maeng, JS; Cho, YJ; Lee, SW,期刊:Biochemical and Biophysical Research Communications, 页码:414-420 , 文章类型: Article,,卷期:2012年417-1]
- Escherichia colt (E. colt) O157:H7 is a major foodborne pathogen that causes life-threatening symptoms in humans worldwide. To rapidly and properly identify the pathogen and avoid its toxic effects, ligands which can dir...
- Adeno-associated virus Rep-mediated targeting of integrase-defective retroviral vector DNA circles into human chromosome 19
[作者:Huang, SH; Kawabe, Y; Ito, A; Kamihira, M,期刊:Biochemical and Biophysical Research Communications, 页码:78-83 , 文章类型: Article,,卷期:2012年417-1]
- Retroviral vectors have been employed in clinical trials for gene therapy owing to their relative large packaging capacity, alterable cell tropism, and chromosomal integration for stable transgene expression. However, un...
- Structural insight into the role of Streptococcus parasanguinis Fap1 within oral biofilm formation
[作者:Garnett, JA; Simpson, PJ; Taylor, J; Benjamin, SV; Tagliaferri, C; Cota, E; Chen, YYM; Wu, H; Matthews, S,期刊:Biochemical and Biophysical Research Communications, 页码:421-426 , 文章类型: Article,,卷期:2012年417-1]
- The fimbriae-associated protein 1 (Fap1) is a major adhesin of Streptococcus parasanguinis, a primary colonizer of the oral cavity that plays an important role in the formation of dental plaque. Fap1 is an extracellular ...
- Phosphorylation of human INO80 is involved in DNA damage tolerance
[作者:Kato, D; Waki, M; Umezawa, M; Aoki, Y; Utsugi, T; Ohtsu, M; Murakami, Y,期刊:Biochemical and Biophysical Research Communications, 页码:433-438 , 文章类型: Article,,卷期:2012年417-1]
- Double strand breaks (DSBs) are the most serious type of DNA damage. DSBs can be generated directly by exposure to ionizing radiation or indirectly by replication fork collapse. The DNA damage tolerance pathway, which is...
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