- Phenylenediamine derivatives induce GDF-15/MIC-1 and inhibit adipocyte differentiation of mouse 3T3-L1 Cells
[作者:Yanagitai, M; Kitagawa, T; Okawa, K; Koyama, H; Satoh, T,期刊:Biochemical and Biophysical Research Communications, 页码:294-298 , 文章类型: Article,,卷期:2012年417-1]
- Phenylenediamine derivatives can function as a hydrogen donor and reportedly exert various biological actions including cytoprotective effects against oxidative stress, possibly by acting as an antioxidant. Previous stud...
- The Brucella TIR-like protein TcpB interacts with the death domain of MyD88
[作者:Chaudhary, A; Ganguly, K; Cabantous, S; Waldo, GS; Micheva-Viteva, SN; Nag, K; Hlavacek, WS; Tung, CS,期刊:Biochemical and Biophysical Research Communications, 页码:299-304 , 文章类型: Article,,卷期:2012年417-1]
- The pathogen Brucella melitensis secretes a Toll/interleukin-1 receptor (TIR) domain containing protein that abrogates host innate immune responses. In this study, we have characterized the biochemical interactions of Br...
- Functional analysis of alpha 1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cells
[作者:Guo, QY; Guo, B; Wang, YM; Wu, J; Jiang, WJ; Zhao, SN; Qiao, SY; Wu, YH,期刊:Biochemical and Biophysical Research Communications, 页码:311-317 , 文章类型: Article,,卷期:2012年417-1]
- The alpha 1,3/4-fucosyltransferases (FUT) subfamily are key enzymes in cell surface antigen synthesis during various biological processes. A novel role of FUTs in tumorigenesis has been discovered recently, however, the ...
- Structural basis of anthrax edema factor neutralization by a neutralizing antibody
[作者:Makiya, M; Dolan, M; Agulto, L; Purcell, R; Chen, ZC,期刊:Biochemical and Biophysical Research Communications, 页码:324-329 , 文章类型: Article,,卷期:2012年417-1]
- Fine epitope mapping of EF13D, a highly potent neutralizing monoclonal antibody specific for the anthrax edema factor (EF), was accomplished through random mutagenesis and yeast surface display. A yeast-displayed library...
- A natural small molecule voacangine inhibits angiogenesis both in vitro and in vivo
[作者:Kim, Y; Jung, HJ; Kwon, HJ,期刊:Biochemical and Biophysical Research Communications, 页码:330-334 , 文章类型: Article,,卷期:2012年417-1]
- Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a critical role in normal and pathological phenotypes, including solid tumor growth and metastasis. Accordingly, the development of new anti-...
- c-Jun N-terminal kinase 2 phosphorylates endothelial nitric oxide synthase at serine 116 and regulates nitric oxide production
[作者:Park, JH; Park, M; Byun, CJ; Jo, I,期刊:Biochemical and Biophysical Research Communications, 页码:340-345 , 文章类型: Article,,卷期:2012年417-1]
- The c-Jun N-terminal kinases (JNKs) belonging to the mitogen-activated protein kinase (MAPK) superfamily play important roles in foam-cell formation, hypercholesterolemia-mediated endothelial dysfunction, and the develop...
- Lysosomal targeting of phafin1 mediated by Rab7 induces autophagosome formation
[作者:Lin, WJ; Yang, CY; Li, LL; Yi, YH; Chen, KW; Lin, YC; Liu, CC; Lin, CH,期刊:Biochemical and Biophysical Research Communications, 页码:35-42 , 文章类型: Article,,卷期:2012年417-1]
- Autophagy orchestrates programmed cell death via crossroads of complex vesicle trafficking including autophagosome and lysosome interaction. Phafin1, an endosome proteins composed of Pleckstrin homology (PH) and Fab1-Yot...
- Autophagy regulates inflammation in adipocytes
[作者:Yoshizaki, T; Kusunoki, C; Kondo, M; Yasuda, M; Kume, S; Morino, K; Sekine, O; Ugi, S; Uzu, T; Nishio, Y; Kashiwagi, A; Maegawa, H,期刊:Biochemical and Biophysical Research Communications, 页码:352-357 , 文章类型: Article,,卷期:2012年417-1]
- Autophagy is an essential process for both the maintenance and the survival of cells, with homeostatic low levels of autophagy being critical for intracellular organelles and proteins. In insulin resistant adipocytes, va...
- Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice
[作者:Yamagishi, N; Ueda, T; Mori, A; Saito, Y; Hatayama, T,期刊:Biochemical and Biophysical Research Communications, 页码:364-370 , 文章类型: Article,,卷期:2012年417-1]
- To identify molecular targets associated with the development of diabetes, we analyzed the hepatic proteome of obese diabetic db/db mice using electrophoresis on a high-resolution two-dimensional gel combined with matrix...
- Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc
[作者:Liu, YC; Yin, BD; Zhang, CC; Zhou, LB; Fan, J,期刊:Biochemical and Biophysical Research Communications, 页码:371-375 , 文章类型: Article,,卷期:2012年417-1]
- Widespread functions of the c-myc pathway play a crucial role in renal cell carcinoma (RCC) carcinogenesis. Thus, we evaluated the connection between proto-oncogenic c-myc and anti-neoplastic hsa-let-7a (let-7a) in RCC c...
- Direct central nervous system delivery provides enhanced protection following vector mediated gene replacement in a severe model of Spinal Muscular Atrophy
[作者:Glascock, JJ; Shababi, M; Wetz, MJ; Krogman, MM; Lorson, CL,期刊:Biochemical and Biophysical Research Communications, 页码:376-381 , 文章类型: Article,,卷期:2012年417-1]
- Spinal Muscular Atrophy (SMA), an autosomal recessive neuromuscular disorder, is the leading genetic cause of infant mortality. SMA is caused by the homozygous loss of Survival Motor Neuron-1 (SMN1). SMA, however, is not...
- Sulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases
[作者:Henry, BL; Thakkar, JN; Liang, AY; Desai, UR,期刊:Biochemical and Biophysical Research Communications, 页码:382-386 , 文章类型: Article,,卷期:2012年417-1]
- Sulfated low molecular weight lignins (LMWLs), designed as oligomeric mimetics of low molecular weight heparins (LMWHs), have been found to bind in exosite II of thrombin [12]. To assess whether sulfated LMWLs recognize ...
- HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops
[作者:Tsurumaru, Y; Sasaki, K; Miyawaki, T; Uto, Y; Momma, T; Umemoto, N; Momose, M; Yazaki, K,期刊:Biochemical and Biophysical Research Communications, 页码:393-398 , 文章类型: Article,,卷期:2012年417-1]
- Female flowers of hop (Humulus lupulus L) develop a large number of glandular trichomes called lupulin glands that contain a variety of prenylated compounds such as alpha- and beta-acid (humulone and lupulone, respective...
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