- Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an upregulation of c-Myc target genes
[作者:Wang, B; Hikosaka, K; Sultana, N; Sharkar, MTK; Noritake, H; Kimura, W; Wu, YX; Kobayashi, Y; Uezato, T; Miura, N,期刊:Biochemical and Biophysical Research Communications, 页码:601-606 , 文章类型: Article,,卷期:2012年417-1]
- The retinoblastoma (Rb) tumor suppressor encodes a nuclear phosphoprotein that regulates cellular proliferation, apoptosis and differentiation. In order to adapt itself to these biological functions, Rb is subjected to m...
- Glycosylphosphatidylinositol (GPI)-anchoring of mamba toxins enables cell-restricted receptor silencing
[作者:Nareoja, K; Louhivuori, LM; Akerman, KEO; Meriluoto, J; Nasman, J,期刊:Biochemical and Biophysical Research Communications, 页码:93-97 , 文章类型: Article,,卷期:2012年417-1]
- Muscarinic toxins (MTs) are snake venom peptides found to selectively target specific subtypes of G-protein-coupled receptors. In here, we have attached a glycosylphosphatidylinositol (GPI) tail to three different toxin ...
- Cells with dysfunctional telomeres are susceptible to reactive oxygen species hydrogen peroxide via generation of multichromosomal fusions and chromosomal fragments bearing telomeres
[作者:Woo, SR; Park, JE; Juhn, KM; Ju, YJ; Jeong, J; Kang, CM; Yun, HJ; Yun, MY; Shin, HJ; Joo, HY; Park, ER; Park, IC; Hong, SH; Hwang, SG; Kim, H; Cho, MH; Kim, SH; Park, GH; Lee, KH,期刊:Biochemical and Biophysical Research Communications, 页码:204-210 , 文章类型: Article,,卷期:2012年417-1]
- During genotoxic stress, reactive oxygen species hydrogen peroxide (H2O2) is a prime mediator of the DNA damage response. Telomeres function both to assist in DNA damage repair and to inhibit chromosomal end-to-end fusio...
- Transgenic over-expression of interleukin-33 in osteoblasts results in decreased osteoclastogenesis
[作者:Keller, J; Catala-Lehnen, P; Wintges, K; Schulze, J; Bickert, T; Ito, W; Horst, AK; Amling, M; Schinke, T,期刊:Biochemical and Biophysical Research Communications, 页码:217-222 , 文章类型: Article,,卷期:2012年417-1]
- Interleukin-33 (IL-33) is the most recently identified member of the IL-1 family of cytokines, which is primarily known for its proinflammatory functions. We have previously reported that IL-33 is expressed by bone-formi...
- p38 mitogen-activated protein kinase is a key regulator of 5-phenylselenyl- and 5-methylselenyl-methyl-2 '-deoxyuridine-induced apoptosis in human HL-60 cells
[作者:Kim, BM; Lee, KH; Hong, IS; Hong, SH,期刊:Biochemical and Biophysical Research Communications, 页码:237-244 , 文章类型: Article,,卷期:2012年417-1]
- Two novel, modified thymidine nucleosides, 5-phenylselenyl-methyl-2'-deoxyuridine (PhSe-T) and 5-methylselenyl-methyl-2'-deoxyuridine (MeSe-T), trigger reactive oxygen species (ROS) generation and DNA damage and thereby ...
- Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium
[作者:Rennolds, J; Malireddy, S; Hassan, F; Tridandapani, S; Parinandi, N; Boyaka, PN; Cormet-Boyaka, E,期刊:Biochemical and Biophysical Research Communications, 页码:256-261 , 文章类型: Article,,卷期:2012年417-1]
- Cadmium is a toxic metal present in the environment and its inhalation can lead to pulmonary disease such as lung cancer and chronic obstructive pulmonary disease. These lung diseases are characterized by chronic inflamm...
- Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population
[作者:Sato, K; Iwai, A; Nakayama, Y; Morimoto, J; Takada, A; Maruyama, M; Kida, H; Uede, T; Miyazaki, T,期刊:Biochemical and Biophysical Research Communications, 页码:274-279 , 文章类型: Article,,卷期:2012年417-1]
- Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection. However, the function of OPN against the infec...
- The role of Roquin overexpression in the modulation of signaling during in vitro and ex vivo T-cell activation
[作者:Kim, HJ; Ji, YR; Kim, MO; Yu, DH; Shin, MJ; Yuh, HS; Bae, KB; Park, SJ; Yi, JK; Kim, NR; Park, SJ; Yoon, DH; Lee, WH; Lee, S; Ryoo, ZY,期刊:Biochemical and Biophysical Research Communications, 页码:280-286 , 文章类型: Article,,卷期:2012年417-1]
- The T-cell receptor (TCR) engages with an antigen and initiates a signaling cascade that leads to the activation of transcription factors. Roquin, a protein encoded by the RC3H1 gene and characterized as an immune regula...
- Theaflavin attenuates ischemia-reperfusion injury in a mouse fatty liver model
[作者:Luo, XY; Takahara, T; Hou, JG; Kawai, K; Sugiyama, T; Tsukada, K; Takemoto, M; Takeuchi, M; Zhong, L; Li, XK,期刊:Biochemical and Biophysical Research Communications, 页码:287-293 , 文章类型: Article,,卷期:2012年417-1]
- The incidence of non-alcoholic fatty liver disease (NAFLD) has been increasing, and there is a shortage of liver donors, which has led to the acceptance of steatotic livers for transplantation. However, steatotic livers ...
- Expression of programmed cell death protein 4 (PDCD4) and miR-21 in urothelial carcinoma
[作者:Fischer, N; Goke, F; Splittstosser, V; Lankat-Buttgereit, B; Muller, SC; Ellinger, J,期刊:Biochemical and Biophysical Research Communications, 页码:29-34 , 文章类型: Article,,卷期:2012年417-1]
- Background: We investigated the role of the programmed cell death 4 (PDCD4) tumor suppressor gene in specimens of transitional cell carcinoma and of healthy individuals. Methods: PDCD4 immunohistochemical expression was ...
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