- Mechanical stimulation of cyclic tensile strain induces reduction of pluripotent related gene expressions via activation of Rho/ROCK and subsequent decreasing of AKT phosphorylation in human induced pluripotent stem cells
[作者:Teramura, T; Takehara, T; Onodera, Y; Nakagawa, K; Hamanishi, C; Fukuda, K,期刊:Biochemical and Biophysical Research Communications, 页码:836-841 , 文章类型: Article,,卷期:2012年417-2]
- Mechanical stimulation has been shown to regulate the proliferation and differentiation of stem cells. However, the effects of the mechanical stress on the sternness or related molecular mechanisms have not been well det...
- Luteolin enhances TNF-related apoptosis-inducing ligand's anticancer activity in a lung cancer xenograft mouse model
[作者:Yan, JQ; Wang, Q; Zheng, XL; Sun, H; Zhou, YQ; Li, DX; Lin, Y; Wang, X,期刊:Biochemical and Biophysical Research Communications, 页码:842-846 , 文章类型: Article,,卷期:2012年417-2]
- Sensitization of cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by luteolin has been suggested by in vitro studies. However, no in vivo experiment has been reported t...
- Mouse transient receptor potential channel 6: Role in hemostasis and thrombogenesis
[作者:Espinosa, EVP; Murad, JP; Ting, HJ; Khasawneh, FT,期刊:Biochemical and Biophysical Research Communications, 页码:853-856 , 文章类型: Article,,卷期:2012年417-2]
- Although changes in the intracellular levels of calcium (Ca2+) are a central step in platelet activation, the underlying mechanism of Ca2+ entry is still unclear. Previous studies have demonstrated that TRPC6, a member o...
- The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts
[作者:Ahn, JH; Ahn, SK; Lee, M,期刊:Biochemical and Biophysical Research Communications, 页码:857-863 , 文章类型: Article,,卷期:2012年417-2]
- In human cancers, B-Raf is the most frequently mutated protein kinase in the MAPK signaling cascade, making it an important therapeutic target. We recently discovered a potent and selective B-Raf inhibitor, UI-152, by us...
- Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo
[作者:Lei, XF; Lv, XG; Liu, M; Yang, ZR; Ji, MY; Guo, XF; Dong, WG,期刊:Biochemical and Biophysical Research Communications, 页码:864-868 , 文章类型: Article,,卷期:2012年417-2]
- Thymoquinone (TQ), a component derived from the bioactive constituent of black seed (Nigella sativa), has been shown to exert biological activity on various types of human cancers. However, there are few studies addressi...
- Ellagic acid in pomegranate suppresses resistin secretion by a novel regulatory mechanism involving the degradation of intracellular resistin protein in adipocytes
[作者:Makino-Wakagi, Y; Yoshimura, Y; Uzawa, Y; Zaima, N; Moriyama, T; Kawamura, Y,期刊:Biochemical and Biophysical Research Communications, 页码:880-885 , 文章类型: Article,,卷期:2012年417-2]
- Resistin, an adipocytokine, is considered the link between obesity and type 2 diabetes. Pomegranate is a rich source of compounds used to treat metabolic diseases including type 2 diabetes. In this study, we found that c...
- GacA directly regulates expression of several virulence genes in Pseudomonas syringae pv. tabaci 11528
[作者:Cha, JY; Lee, DG; Lee, JS; Oh, JI; Baik, HS,期刊:Biochemical and Biophysical Research Communications, 页码:665-672 , 文章类型: Article,,卷期:2012年417-2]
- A two-component system comprising GacS and GacA affects a large number of traits in many Gram-negative bacteria. However, the signals to which GacS responds, the regulation mechanism for GacA expression, and the genes Ga...
- Chemoresistance to 5-fluorouracil induces epithelial-mesenchymal transition via up-regulation of Snail in MCF7 human breast cancer cells
[作者:Zhang, WJ; Feng, ML; Zheng, GP; Chen, Y; Wang, XD; Pen, B; Yin, J; Yu, YH; He, ZM,期刊:Biochemical and Biophysical Research Communications, 页码:679-685 , 文章类型: Article,,卷期:2012年417-2]
- 5-Fluorouracil (5-FU) is commonly used to treat breast cancer; however, it becomes increasingly ineffective with tumor progression. Epithelial-to-mesenchymal transition (EMT) is a process whereby cells acquire morphologi...
- Differential expression of microRNA and predicted targets in pulmonary sarcoidosis
[作者:Crouser, ED; Julian, MW; Crawford, M; Shao, GH; Yu, LB; Planck, SR; Rosenbaum, JT; Nana-Sinkam, SP,期刊:Biochemical and Biophysical Research Communications, 页码:886-891 , 文章类型: Article,,卷期:2012年417-2]
- Background: Recent studies show that various inflammatory diseases are regulated at the level of RNA translation by small non-coding RNAs, termed microRNAs (miRNAs). We sought to determine whether sarcoidosis tissues har...
- Genome-wide identification of cold-responsive and new microRNAs in Populus tomentosa by high-throughput sequencing
[作者:Chen, L; Zhang, YY; Ren, YY; Xu, JC; Zhang, ZY; Wang, YW,期刊:Biochemical and Biophysical Research Communications, 页码:892-896 , 文章类型: Article,,卷期:2012年417-2]
- MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression of target mRNAs in plant growth, development, abiotic stress responses, and pathogen responses. Cold stress is one of the most common abiotic fac...
- Diospyrin derivative, an anticancer quinonoid, regulates apoptosis at endoplasmic reticulum as well as mitochondria by modulating cytosolic calcium in human breast carcinoma cells
[作者:Kumar, B; Kumar, A; Ghosh, S; Pandey, BN; Mishra, KP; Hazra, B,期刊:Biochemical and Biophysical Research Communications, 页码:903-909 , 文章类型: Article,,卷期:2012年417-2]
- Diospyrin diethylether (D7), a bisnaphthoquinonoid derivative, exhibited an oxidative stress-dependent apoptosis in several human cancer cells and tumor models. The present study was aimed at evaluation of the increase i...
- Diphosphorylated but not monophosphorylated myosin II regulatory light chain localizes to the midzone without its heavy chain during cytokinesis
[作者:Kondo, T; Isoda, R; Uchimura, T; Sugiyama, M; Hamao, K; Hosoya, H,期刊:Biochemical and Biophysical Research Communications, 页码:686-691 , 文章类型: Article,,卷期:2012年417-2]
- Myosin II is activated by the monophosphorylation of its regulatory light chain (MRLC) at Ser19 (1P-MRLC). Its ATPase activity is further enhanced by MRLC diphosphorylation at Thr18/Ser19 (2P-MRLC). As these phosphorylat...
- Activation of voltage gated K+ channel Kv1.5 by beta-catenin
[作者:Munoz, C; Tovolli, RH; Sopjani, M; Alesutan, I; Lam, RS; Seebohm, G; Foller, M; Lang, F,期刊:Biochemical and Biophysical Research Communications, 页码:692-696 , 文章类型: Article,,卷期:2012年417-2]
- Voltage-gated Kv1.5 channels are expressed in a wide variety of tissues including cardiac myocytes, smooth muscle and tumor cells. Kv1.5 channel activity is modified by N-cadherin, which in turn binds the multifunctional...
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