- Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-kappa B, p38MAPK and Akt inhibition
[作者:Essafi-Benkhadir, K; Refai, A; Riahi, I; Fattouch, S; Karoui, H; Essafi, M,期刊:Biochemical and Biophysical Research Communications, 页码:180-185 , 文章类型: Article,,卷期:2012年418-1]
- Chronic inflammation is a hallmark of several pathologies, such as rheumatoid arthritis, gastritis, inflammatory bowel disease, atherosclerosis and cancer. A wide range of anti-inflammatory chemicals have been used to tr...
- Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells
[作者:Huang, HH; Zhao, WR; Yang, D,期刊:Biochemical and Biophysical Research Communications, 页码:186-190 , 文章类型: Article,,卷期:2012年418-1]
- Dysregulated Skp2 function promotes cell proliferation, which is consistent with observations of Skp2 over-expression in many types of human cancers, including cervical carcinoma (CC). However, the molecular mechanisms u...
- Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia
[作者:Yanagitai, M; Itoh, S; Kitagawa, T; Takenouchi, T; Kitani, H; Satoh, T,期刊:Biochemical and Biophysical Research Communications, 页码:22-26 , 文章类型: Article,,卷期:2012年418-1]
- In the previous studies, we reported that carnosic acid (CA) protects cortical neurons by activating the Keap1/Nrf2 pathway, which activation is initiated by S-alkylation of the critical cysteine thiol of the Keap1 prote...
- PrPC displays an essential protective role from oxidative stress in an astrocyte cell line derived from PrPC knockout mice
[作者:Bertuchi, FR; Bourgeon, DMG; Landemberger, MC; Martins, VR; Cerchiaro, G,期刊:Biochemical and Biophysical Research Communications, 页码:27-32 , 文章类型: Article,,卷期:2012年418-1]
- The PrPC protein, which is especially present in the cellular membrane of nervous system cells, has been extensively studied for its controversial antioxidant activity. In this study, we elucidated the free radical scave...
- Epitope mapping of neutralizing monoclonal antibody in avian influenza A H5N1 virus hemagglutinin
[作者:Ohkura, T; Kikuchi, Y; Kono, N; Itamura, S; Komase, K; Momose, F; Morikawa, Y,期刊:Biochemical and Biophysical Research Communications, 页码:38-43 , 文章类型: Article,,卷期:2012年418-1]
- The global spread of highly pathogenic avian influenza A H5N1 viruses raises concerns about more widespread infection in the human population. Pre-pandemic vaccine for H5N1 clade 1 influenza viruses has been produced fro...
- Differential effects of substrate-analogue inhibitors on nitric oxide synthase dimerization
[作者:Lee, KS; Lee, DK; Jeoung, D; Lee, H; Choe, J; Ha, KS; Won, MH; Kwon, YG; Kim, YM,期刊:Biochemical and Biophysical Research Communications, 页码:49-55 , 文章类型: Article,,卷期:2012年418-1]
- Nitric oxide synthase (NOS) isoforms are hemoenzymes that are only active as homodimers. We have examined the effect of the substrate-analogue inhibitors, N-G-monomethyl-L-arginine (L-NMA), N-G-nitro-L-arginine (L-NNA), ...
- Notch-ligand expression by NALT dendritic cells regulates mucosal Th1-and Th2-type responses
[作者:Fukuyama, Y; Tokuhara, D; Sekine, S; Kataoka, K; Markham, JD; Irwin, AR; Moon, GH; Tokuhara, Y; Fujihashi, K; Davydova, J; Yamamoto, M; Gilbert, RS; Fujihashi, K,期刊:Biochemical and Biophysical Research Communications, 页码:6-11 , 文章类型: Article,,卷期:2012年418-1]
- Our previous studies showed that an adenovirus (Ad) serotype 5 vector expressing Flt3 ligand (Ad-FL) as nasal adjuvant activates CD11c(+) dendritic cells (DCs) for the enhancement of antigen (Ag)-specific IgA antibody (A...
- Characterization of the ptr5(+) gene involved in nuclear mRNA export in fission yeast
[作者:Watanabe, N; Ikeda, T; Mizuki, F; Tani, T,期刊:Biochemical and Biophysical Research Communications, 页码:62-66 , 文章类型: Article,,卷期:2012年418-1]
- To analyze the mechanisms of mRNA export from the nucleus to the cytoplasm, we have isolated eleven mutants, ptr [poly(A)(+) RNA transport] 1 to 11, which accumulate poly(A)(+) RNA in the nucleus at a non-permissive temp...
- Reduced expression of Kruppel-like factor 17 is related to tumor growth and poor prognosis in lung adenocarcinoma
[作者:Cai, XD; Zhou, YB; Huang, LX; Zeng, QL; Zhang, LJ; Wang, QQ; Li, SL; Feng, JQ; Han, AJ,期刊:Biochemical and Biophysical Research Communications, 页码:67-73 , 文章类型: Article,,卷期:2012年418-1]
- Kruppel-like factor 17 (KLF17), a new member of the Kruppel-like factors (KLFs), has been reported to be a negative regulator of epithelial-mesenchymal transition (EMT) and metastasis in breast cancer. However, the biolo...
- Properties and functions of K-ATP during mouse perinatal development
[作者:Nie, L; Tang, M; Zeng, Y; Jiang, HP; Shi, HC; Luo, HY; Hu, XW; Gao, LL; Xi, JY; Liu, AF; Reppel, M; Hescheler, J; Liang, HM,期刊:Biochemical and Biophysical Research Communications, 页码:74-80 , 文章类型: Article,,卷期:2012年418-1]
- Background: Prevailing data suggest that ATP-sensitive potassium channels (K-ATP) contribute to a surprising resistance to hypoxia in mammalian embryos, thus we aimed to characterize the developmental changes of K-ATP ch...
- A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats
[作者:Nakamura, K; Tsurushima, H; Marushima, A; Nagano, M; Yamashita, T; Suzuki, K; Ohneda, O; Matsumura, A,期刊:Biochemical and Biophysical Research Communications, 页码:87-92 , 文章类型: Article,,卷期:2012年418-1]
- Previous studies have examined the therapeutic effect of endothelial progenitor cells (EPCs) during the chronic phase of cerebral infarction in rats; however, few studies have investigated the effects of EPCs during the ...
- MNT inhibits the migration of human hepatocellular carcinoma SMMC7721 cells
[作者:Wu, J; Zhou, Q; Wang, YF; Zhou, XB; Li, JP,期刊:Biochemical and Biophysical Research Communications, 页码:93-97 , 文章类型: Article,,卷期:2012年418-1]
- Max binding protein (MNT) is a member of the Myc/Max/Mad network that plays a role in cell proliferation, differentiation and apoptosis. We previously observed that MNT was differentially expressed in hepatocellular carc...
- Salinomycin sensitizes antimitotic drugs-treated cancer cells by increasing apoptosis via the prevention of G2 arrest
[作者:Kim, JH; Yoo, HI; Kang, HS; Ro, J; Yoon, S,期刊:Biochemical and Biophysical Research Communications, 页码:98-103 , 文章类型: Article,,卷期:2012年418-1]
- Here, we investigated whether Sal could sensitize cancer cells to antimitotic drugs. We demonstrated that Sal sensitized paclitaxcel (PAC)-, docetaxcel (DOC)-, vinblastin (VIN)-, or colchicine (COL)-treated cancer cell l...
- Recombinant fusion protein of albumin-retinol binding protein inactivates stellate cells
[作者:Choi, S; Park, S; Kim, S; Lim, C; Kim, J; Cha, DR; Oh, J,期刊:Biochemical and Biophysical Research Communications, 页码:191-197 , 文章类型: Article,,卷期:2012年418-1]
- Quiescent pancreatic- (PSCs) and hepatic- (HSCs) stellate cells store vitamin A (retinol) in lipid droplets via retinol binding protein (RBP) receptor and, when activated by profibrogenic stimuli, they transform into myo...
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