- Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3 beta
[作者:Choi, CH; Lee, BH; Ahn, SG; Oh, SH,期刊:Biochemical and Biophysical Research Communications, 页码:759-764 , 文章类型: Article,,卷期:2012年418-4]
- Proteasome inhibition is a promising approach for cancer treatment; however, the underlying mechanisms involved have not been fully elucidated. Here, we show that proteasome inhibition-induced p38 mitogen-activated prote...
- New method to differentiate human peripheral blood monocytes into insulin producing cells: Human hematosphere culture
[作者:Hur, J; Yang, JM; Choi, JI; Yun, JY; Jang, JH; Kim, J; Kim, JY; Oh, IY; Yoon, CH; Cho, HJ; Park, YB; Kim, HS,期刊:Biochemical and Biophysical Research Communications, 页码:765-769 , 文章类型: Article,,卷期:2012年418-4]
- Strategy to differentiate stem cells into insulin producing cells (IPCs) in vitro has been a promising one to get cell source of beta-cell replacement therapy for diabetes. It has been suggested that islets and neurons s...
- The combination of lanthanum chloride and the calcimimetic calindol delays the progression of vascular smooth muscle cells calcification
[作者:Ciceri, P; Volpi, E; Brenna, I; Elli, F; Borghi, E; Brancaccio, D; Cozzolino, M,期刊:Biochemical and Biophysical Research Communications, 页码:770-773 , 文章类型: Article,,卷期:2012年418-4]
- Phosphate (Pi)-binders are commonly used in dialysis patients to control high Pi levels, that associated with vascular calcification (VC). The aim of this study was to investigate the effects of lanthanum chloride (LaCl3...
- Muscle contraction increases carnitine uptake via translocation of OCTN2
[作者:Furuichi, Y; Sugiura, T; Kato, Y; Takakura, H; Hanai, Y; Hashimoto, T; Masuda, K,期刊:Biochemical and Biophysical Research Communications, 页码:774-779 , 文章类型: Article,,卷期:2012年418-4]
- Since carnitine plays an important role in fat oxidation, influx of carnitine could be crucial for muscle metabolism. OCTN2 (SLC22A5), a sodium-dependent solute carrier, is assumed to transport carnitine into skeletal mu...
- The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity
[作者:Meissner, TB; Li, A; Liu, YJ; Gagnon, E; Kobayashi, KS,期刊:Biochemical and Biophysical Research Communications, 页码:786-791 , 文章类型: Article,,卷期:2012年418-4]
- Major histocompatibility complex (MHC) class I and class II are crucial for the function of the human adaptive immune system. A member of the NLR (nucleotide-binding domain, leucine-rich repeat) protein family, NLRC5, ha...
- Protein phosphatase 2A effectively modulates basal L-type Ca2+ current by dephosphorylating Ca(v)1.2 at serine 1866 in mouse cardiac myocytes
[作者:Shi, J; Gu, PY; Zhu, ZH; Liu, JX; Chen, Z; Sun, XL; Chen, W; Gao, X; Zhang, Z,期刊:Biochemical and Biophysical Research Communications, 页码:792-798 , 文章类型: Article,,卷期:2012年418-4]
- Calcium (Ca2+) influx through Ca(v)1.2 L-type Ca2+ channels is an important event for cardiac excitation-contraction (E-C) coupling. The functional regulation of Ca(v)1.2 is controlled by multiple kinases and phosphatase...
- NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
[作者:Matsui, K; Ezoe, S; Oritani, K; Shibata, M; Tokunaga, M; Fujita, N; Tanimura, A; Sudo, T; Tanaka, H; McBurney, MW; Matsumura, I; Kanakura, Y,期刊:Biochemical and Biophysical Research Communications, 页码:811-817 , 文章类型: Article,,卷期:2012年418-4]
- Sir2 has been shown to be essential for transcriptional silencing and longevity provided by calorie restriction in Saccharomyces cerevisiae and Caenorhabditis elegans. In this study, we investigated the role for its mamm...
- Identification and functional characterization of the novel human ether-a-go-go-related gene (hERG) R744P mutant associated with hereditary long QT syndrome 2
[作者:Aidery, P; Kisselbach, J; Gaspar, H; Baldea, L; Schweizer, PA; Becker, R; Katus, HA; Thomas, D,期刊:Biochemical and Biophysical Research Communications, 页码:830-835 , 文章类型: Article,,卷期:2012年418-4]
- Mutations of the cyclic nucleotide binding domain (CNBD) may disrupt human ether-a-go-go-related gene (hERG) K+ channel function and lead to hereditary long QT syndrome (LQTS). We identified a novel missense mutation loc...
- Crystal structure of inactive form of Rab3B
[作者:Zhang, W; Shen, Y; Jiao, RH; Liu, YL; Deng, LF; Qi, C,期刊:Biochemical and Biophysical Research Communications, 页码:841-844 , 文章类型: Article,,卷期:2012年418-4]
- Rab proteins are the largest family of ras-related GTPases in eukaryotic cells. They act as directional molecular switches at membrane trafficking, including vesicle budding, cargo sorting, transport, tethering, and fusi...
- Cytokine-induced human islet cell death in vitro correlates with a persistently high phosphorylation of STAT-1, but not with NF-kappa B activation
[作者:Hindlycke, H; Lu, T; Welsh, N,期刊:Biochemical and Biophysical Research Communications, 页码:845-850 , 文章类型: Article,,卷期:2012年418-4]
- Studies of insulin producing beta-cells have reported conflicting responses to NF-kappa B activation, encompassing both pro- and anti-apoptotic effects, possibly reflecting the use of beta-cells from different species. T...
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