- Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation is associated with cell-type-dependent splicing of mtAspRS mRNA
[作者:van Berge, L; Dooves, S; van Berkel, CGM; Polder, E; van der Knaap, MS; Scheper, GC,期刊:Biochemical Journal, 页码:955-962 , 文章类型: Article,,卷期:2012年441-3]
- LBSL (leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation) is an autosomal recessive white matter disorder with slowly progressive cerebellar ataxia, spasticity and dorsal column dysfunc...
- alpha-Haemoglobin regulates sympathoadrenal cell metabolism to maintain a catecholaminergic phenotype
[作者:Marcos-Almaraz, MT; Rodriguez-Gomez, JA; Lopez-Barneo, J; Pascual, A,期刊:Biochemical Journal, 页码:843-850 , 文章类型: Article,,卷期:2012年441-3]
- Discovery of haemoglobin A expression outside of the erythroid cell lineage suggests that oxygen transport is the main, but not the unique, function of adult haemoglobin chains in mammals. The contribution of haemoglobin...
- The p101 subunit of PI3K gamma restores activation by G beta mutants deficient in stimulating p110 gamma
[作者:Shymanets, A; Ahmadian, MR; Kossmeier, KT; Wetzker, R; Harteneck, C; Nurnberg, B,期刊:Biochemical Journal, 页码:851-858 , 文章类型: Article,,卷期:2012年441-3]
- G-protein-regulated PI3K gamma (phosphoinositide 3-kinase gamma) plays a crucial role in inflammatory and allergic processes. PI3K gamma, a dimeric protein formed by the non-catalytic p101 and catalytic p110 gamma subuni...
- Large T-antigen up-regulates K(v)4.3 K+ channels through Sp1, and K(v)4.3 K+ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase II
[作者:Li, Q; Zhang, Y; Sheng, Y; Huo, R; Sun, B; Teng, X; Li, N; Zhu, JX; Yang, BF; Dong, DL,期刊:Biochemical Journal, 页码:859-867 , 文章类型: Article,,卷期:2012年441-3]
- Down-regulation of K(v)4.3 K+ channels commonly occurs in multiple diseases, but the understanding of the regulation of K(v)4.3 K+ channels and the role of K(v)4.3 K+ channels in pathological conditions are limited. HEK ...
- The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor-mediated Rho kinase signalling
[作者:Arulpragasam, A; Magno, AL; Ingley, E; Brown, SJ; Conigrave, AD; Ratajczak, T; Ward, BK,期刊:Biochemical Journal, 页码:995-1006 , 文章类型: Article,,卷期:2012年441-3]
- A yeast two-hybrid screen performed to identify binding partners of the CaR (calcium-sensing receptor) intracellular tail identified the adaptor protein 14-3-3 theta as a novel binding partner that bound to the proximal ...
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