- Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1
[作者：Platta, HW; Abrahamsen, H; Thoresen, SB; Stenmark, H,期刊：Biochemical Journal, 页码：399-406 , 文章类型： Article，,卷期：2012年441-1]
- Beclin 1, a subunit of the class III phosphatidylinositol 3-kinase complex, is a tumour suppressor with a central role in endocytic trafficking, cytokinesis and the cross-regulation between autophagy and apoptosis. Inter...
- Phospholipase D1 mediates bFGF-induced Bcl-2 expression leading to neurite outgrowth in H19-7 cells
[作者：Yoon, SN; Kim, KS; Cho, JH; Ma, W; Choi, HJ; Kwon, SJ; Han, JS,期刊：Biochemical Journal, 页码：407-416 , 文章类型： Article，,卷期：2012年441-1]
- The purpose of the present study was to investigate the role of PLD (phospholipase D) in bFGF (basic fibroblast growth factor)induced Bcl-2 expression and to examine whether overexpressed Bcl-2 influences neurite outgrow...
- Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans
[作者：Zhang, HR; Pan, N; Xiong, SQ; Zou, SL; Li, HF; Xiao, LY; Cao, ZJ; Tunnacliffe, A; Huang, ZB,期刊：Biochemical Journal, 页码：417-424 , 文章类型： Article，,卷期：2012年441-1]
- Late-onset neurodegenerative diseases are characterized by progressive accumulation of aggregation-prone proteins and global disruption of the proteostasis network, e.g. abnormal polyQ (polyglutamine) aggregation in Hunt...
- Selection of non-competitive leptin antagonists using a random nanobody-based approach
[作者：Zabeau, L; Verhee, A; Catteeuw, D; Faes, L; Seeuws, S; Decruy, T; Elewaut, D; Peelman, F; Tavernier, J,期刊：Biochemical Journal, 页码：425-434 , 文章类型： Article，,卷期：2012年441-1]
- The adipocyte-derived cytokine leptin acts as a metabolic switch, connecting the body's metabolism to high-energy consuming processes such as reproduction and immune responses. Accumulating evidence suggests that leptin ...
- NAADP regulates human platelet function
[作者：Coxon, CH; Lewis, AM; Sadler, AJ; Vasudevan, SR; Thomas, A; Dundas, KA; Taylor, L; Campbell, RD; Gibbins, JM; Churchill, GC; Tucker, KL,期刊：Biochemical Journal, 页码：435-442 , 文章类型： Article，,卷期：2012年441-1]
- Platelets play a vital role in maintaining haemostasis. Human platelet activation depends on Ca(2+) release, leading to cell activation, granule secretion and aggregation. NAADP (nicotinic acid-adenine dinucleotide phosp...
- Extravesicular intraneuronal migration of internalized botulinum neurotoxins without detectable inhibition of distal neurotransmission
[作者：Lawrence, GW; Ovsepian, SV; Wang, JF; Aoki, KR; Dolly, JO,期刊：Biochemical Journal, 页码：443-452 , 文章类型： Article，,卷期：2012年441-1]
- Intracellular protein transport routes can be studied using toxins that exploit these to enter cells. BoNT(A) (botulinum neurotoxin type A) is a protease that binds to peripheral nerve terminals, becomes endocytosed and ...
- Identification of novel small molecules that elevate Klotho expression
[作者：King, GD; Chen, CD; Huang, MM; Zeldich, E; Brazee, PL; Schuman, ER; Robin, M; Cuny, GD; Glicksman, MA; Abraham, CR,期刊：Biochemical Journal, 页码：453-461 , 文章类型： Article，,卷期：2012年441-1]
- The absence of Klotho (KL) from mice causes the development of disorders associated with human aging and decreased longevity, whereas increased expression prolongs lifespan. With age, KL protein levels decrease, and keep...
- Neurotrophin-4 modulates the mechanotransducer Ca(v)3.2 T-type calcium current in mice down-hair neurons
[作者：Hilaire, C; Lucas, O; Valmier, J; Scamps, F,期刊：Biochemical Journal, 页码：463-471 , 文章类型： Article，,卷期：2012年441-1]
- The T-type Ca(2+) channel Ca(v)3.2 is expressed in nociceptive and mechanosensitive sensory neurons. The mechanosensitive D-hair (down-hair) neurons, which innervate hair follicles, are characterized by a large-amplitude...
- Mutation in the Fe-S scaffold protein Isu bypasses frataxin deletion
[作者：Yoon, H; Golla, R; Lesuisse, E; Pain, J; Donald, JE; Lyver, ER; Pain, D; Dancis, A,期刊：Biochemical Journal, 页码：473-480 , 文章类型： Article，,卷期：2012年441-1]
- Frataxin is a conserved mitochondrial protein deficient in patients with Friedreich's ataxia. Frataxin has been implicated in control of iron homoeostasis and Fe-S cluster assembly. In yeast or human mitochondria, fratax...
- Directed evolution of a temperature-, peroxide- and alkaline pH-tolerant versatile peroxidase
[作者：Garcia-Ruiz, E; Gonzalez-Perez, D; Ruiz-Duenas, FJ; Martinez, AT; Alcalde, M,期刊：Biochemical Journal, 页码：487-498 , 文章类型： Article，,卷期：2012年441-1]
- The VPs (versatile peroxidases) secreted by white-rot fungi are involved in the natural decay of lignin. In the present study, a fusion gene containing the VP from Pleurotus eryngii was subjected to six rounds of directe...
- Connective tissue growth factor antagonizes transforming growth factor-beta 1/Smad signalling in renal mesangial cells
[作者：O'Donovan, HC; Hickey, F; Brazil, DP; Kavanagh, DH; Oliver, N; Martin, F; Godson, C; Crean, J,期刊：Biochemical Journal, 页码：499-510 , 文章类型： Article，,卷期：2012年441-1]
- The critical involvement of TGF-beta 1 (transforming growth factor-beta 1) in DN (diabetic nephropathy) is well established. However, the role of CTGF (connective tissue growth factor) in regulating the complex interplay...
- Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21
[作者：Possenti, R; Muccioli, G; Petrocchi, P; Ceros, C; Cabassi, A; Vulchanova, L; Riedl, MS; Manieri, M; Frontini, A; Giordano, A; Cinti, S; Govoni, P; Graiani, G; Quaini, F; Ghe, C; Bresciani, E; Bulgarelli, I; Torsello, A; Locatelli, V; Sanghez, V; Larsen, BD; Petersen, JS; Palanza, P; Parmigiani, S; Moles, A; Levi, A; Bartolomucci, A,期刊：Biochemical Journal, 页码：511-522 , 文章类型： Article，,卷期：2012年441-1]
- The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scrutinized as biomarkers for human disease. An endocrine/neuromodulatory role for VGF peptides has been suggested but never...
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