- A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E
[作者：Paku, KS; Umenaga, Y; Usui, T; Fukuyo, A; Mizuno, A; In, Y; Ishida, T; Tomoo, K,期刊：Biochemical Journal, 页码：237-245 , 文章类型： Article，,卷期：2012年441-1]
- Although the central alpha-helical Y(X)(4)L Phi motif (X, variable amino acid; Phi, hydrophobic amino acid) of the translational regulator 4E-BP [eIF (eukaryotic initiation factor) 4E-binding protein] is the core binding...
- Translation of a minigene in the 5 ' leader sequence of the enterohaemorrhagic Escherichia coli LEE1 transcription unit affects expression of the neighbouring downstream gene
[作者：Islam, MS; Shaw, RK; Frankel, G; Pallen, MJ; Busby, SJW,期刊：Biochemical Journal, 页码：247-253 , 文章类型： Article，,卷期：2012年441-1]
- The 5' end of the major RNA transcript of the LEE1 operon of enterohaemorrhagic Escherichia coli contains similar to 170 bases before the AUG translation start codon of the first recognized gene, ler. This unusually long...
- A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress
[作者：Hueso, G; Aparicio-Sanchis, R; Montesinos, C; Lorenz, S; Murguia, JR; Serrano, R,期刊：Biochemical Journal, 页码：255-264 , 文章类型： Article，,卷期：2012年441-1]
- Intracellular pH conditions many cellular systems, but its mechanisms of regulation and perception are mostly unknown. We have identified two yeast genes important for tolerance to intracellular acidification caused by w...
- Relaxin-like factor (RLF)/insulin-like peptide 3 (INSL3) is secreted from testicular Leydig cells as a monomeric protein comprising three domains B-C-A with full biological activity in boars
[作者：Minagawa, I; Fukuda, M; Ishige, H; Kohriki, H; Shibata, M; Park, EY; Kawarasaki, T; Kohsaka, T,期刊：Biochemical Journal, 页码：265-273 , 文章类型： Article，,卷期：2012年441-1]
- RLF (relaxin-like factor), also known as INSL3 (insulin-like peptide 3), is a novel member of the relaxin/insulin gene family that is expressed in testicular Leydig cells. Despite the implicated role of RLF/INSL3 in test...
- LRPPRC mutation suppresses cytochrome oxidase activity by altering mitochondrial RNA transcript stability in a mouse model
[作者：Xu, FH; Addis, JBL; Cameron, JM; Robinson, BH,期刊：Biochemical Journal, 页码：275-283 , 文章类型： Article，,卷期：2012年441-1]
- LRPPRC (leucine-rich pentatricopeptide repeat-containing) has been shown to be essential for the maturation of COX (cytochrome c oxidase), possibly by stabilizing RNA transcripts of COXI, COXII and COXIII genes encoded i...
- Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
[作者：Meakin, PJ; Harper, AJ; Hamilton, DL; Gallagher, J; McNeilly, AD; Burgess, LA; Vaanholt, LM; Bannon, KA; Latcham, J; Hussain, I; Speakman, JR; Howlett, DR; Ashford, MLJ,期刊：Biochemical Journal, 页码：285-296 , 文章类型： Article，,卷期：2012年441-1]
- Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease). An essential feature of AD pathology is the presence of BACE1 (beta...
- BAG-1 diversely affects steroid receptor activity
[作者：Knapp, RT; Steiner, A; Schmidt, U; Hafner, K; Holsboer, F; Rein, T,期刊：Biochemical Journal, 页码：297-303 , 文章类型： Article，,卷期：2012年441-1]
- Part of the cellular and physiological functions of BAG-1 (Bcl-2-associated athanogene 1) has been ascribed to the ability of this hsp70 (heat-shock protein 70) co-chaperone to regulate steroid receptor activity. BAG-1 h...
- Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage
[作者：Skaff, O; Pattison, DI; Morgan, PE; Bachana, R; Jain, VK; Priyadarsini, KI; Davies, MJ,期刊：Biochemical Journal, 页码：305-316 , 文章类型： Article，,卷期：2012年441-1]
- Elevated MPO (myeloperoxidase) levels are associated with multiple human inflammatory pathologies. MPO catalyses the oxidation of Cl(-), Br(-) and SCN(-) by H(2)O(2) to generate the powerful oxidants hypochlorous acid (H...
- Domain assembly of NAADP-gated two-pore channels
[作者：Churamani, D; Hooper, R; Brailoiu, E; Patel, S,期刊：Biochemical Journal, 页码：317-323 , 文章类型： Article，,卷期：2012年441-1]
- TPCs (two-pore channels) have recently been identified as targets for the Ca(2+)-mobilizing messenger NAADP (nicotinic acid adenine dinucleotide phosphate). TPCs have a unique structure consisting of cytosolic termini, t...
- SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation
[作者：Thastrup, JO; Rafiqi, FH; Vitari, AC; Pozo-Guisado, E; Deak, M; Mehellou, Y; Alessi, DR,期刊：Biochemical Journal, 页码：325-337 , 文章类型： Article，,卷期：2012年441-1]
- Mutations in the WNK with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has been on WNK1, which is activated in response to osmotic stress ...
- Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system
[作者：Goh, ETH; Arthur, JSC; Cheung, PCF; Akira, S; Toth, R; Cohen, P,期刊：Biochemical Journal, 页码：339-346 , 文章类型： Article，,卷期：2012年441-1]
- The E3 ubiquitin ligase Pellino 1 can be interconverted between inactive and active forms by a reversible phosphorylation mechanism. In vitro, phosphorylation and activation can be catalysed by either the IRAKs [IL (inte...
- Determinants of the enzymatic activity and the subcellular localization of aspartate N-acetyltransferase
[作者：Tahay, G; Wiame, E; Tyteca, D; Courtoy, PJ; Van Schaftingen, E,期刊：Biochemical Journal, 页码：105-112 , 文章类型： Article，,卷期：2012年441-1]
- Aspartate N-acetyltransferase (NAT8L, N-acetyltransferase 8-like), the enzyme that synthesizes N-acetylaspartate, is membrane-bound and is at least partially associated with the ER (endoplasmic reticulum). The aim of the...
- PTEN interacts with metal-responsive transcription factor 1 and stimulates its transcriptional activity
[作者：Lin, MC; Liu, YC; Tam, MF; Lu, YJ; Hsieh, YT; Lin, LY,期刊：Biochemical Journal, 页码：367-377 , 文章类型： Article，,卷期：2012年441-1]
- MTF-1 (metal-responsive transcription factor 1) is an essential mammalian protein for embryonic development and modulates the expression of genes involving in zinc homoeostasis and responding to oxidative stress. We repo...
- A common single nucleotide polymorphism A118G of the mu opioid receptor alters its N-glycosylation and protein stability
[作者：Huang, P; Chen, CG; Mague, SD; Blendy, JA; Liu-Chen, LY,期刊：Biochemical Journal, 页码：379-386 , 文章类型： Article，,卷期：2012年441-1]
- The A118G SNP (single nucleotide polymorphism) of the hMOPR [human MOPR (mu, opioid receptor)] gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous for the 1180 allele have been reported to requir...
- Thr(90) phosphorylation of Hsp90 alpha by protein kinase A regulates its chaperone machinery
[作者：Wang, XF; Lu, XA; Song, XM; Zhuo, W; Jia, L; Jiang, YS; Luo, YZ,期刊：Biochemical Journal, 页码：387-397 , 文章类型： Article，,卷期：2012年441-1]
- Hsp90 (heat-shock protein 90) is one of the most important molecular chaperones in eukaryotes. Hsp90 facilitates the maturation, activation or degradation of its client proteins. It is now well accepted that both ATP bin...
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