- Enhanced Renal Clearance of Vancomycin in Rats with Carcinogen-Induced Osteosarcoma
[作者:Shimada, I; Iwata, C; Taga, S; Teramachi, H; Nomura, MKI; Miyamoto, KI; Tsuciya, H; Wada, T; Kimura, K; Matsushita, R,期刊:Anticancer Research, 页码:823-829 , 文章类型: Article,,卷期:2012年32-3]
- Recently, it has been reported that total clearance (CLtot) of vancomycin is significantly higher in patients with malignancies compared to those without malignancies. In the present study, to clarify the mechanism of th...
- Farnesyltransferase Inhibitors: Molecular Evidence of Therapeutic Efficacy in Acute Lymphoblastic Leukemia Through Cyclin D1 Inhibition
[作者:Costa, CB; Casalta-Lopes, J; Andrade, C; Moreira, D; Oliveira, A; Goncalves, AC; Alves, V; Silva, T; Dourado, M; Nascimento-Costa, JM; Sarmento-Ribeiro, AB,期刊:Anticancer Research, 页码:831-838 , 文章类型: Article,,卷期:2012年32-3]
- Background: Farnesyltransferase inhibitors have the ability to interfere with various intracellular pathways, reducing cell survival and proliferation. They have become an attractive tool for cancer therapy, namely acute...
- Interleukin-21 Increases Direct Cytotoxicity and IFN-gamma Production of Ex Vivo Expanded NK Cells towards Breast Cancer Cells
[作者:Park, YK; Shin, DJ; Cho, D; Kim, SK; Lee, JJ; Shin, MG; Ryang, DW; Lee, JS; Park, MH; Yoon, JH; Jegal, YJ,期刊:Anticancer Research, 页码:839-846 , 文章类型: Article,,卷期:2012年32-3]
- Background/Aim: Interleukin-21(IL-21) stimulates cytotoxicity and interferon-gamma (IFN-gamma) production in natural killer (NK) cells. However, little has been reported on the stimulatory effect of IL-21 on ex vivo expa...
- Proteomic Analysis of Exosome-like Vesicles Derived from Breast Cancer Cells
[作者:Palazzolo, G; Albanese, NN; Di Cara, G; Gygax, D; Vittorelli, ML; Pucci-Minafra, I,期刊:Anticancer Research, 页码:847-860 , 文章类型: Article,,卷期:2012年32-3]
- Background/Aim: The phenomenon of membrane vesicle-release by neoplastic cells is a growing field of interest in cancer research, due to their potential role in carrying a large array of tumor antigens when secreted into...
- SN-38 Overcomes Chemoresistance of Colorectal Cancer Cells Induced by Hypoxia, through HIF1alpha
[作者:Murono, K; Tsuno, NH; Kawai, K; Sasaki, K; Hongo, K; Kaneko, M; Hiyoshi, M; Tada, N; Nirei, T; Sunami, E; Takahashi, K; Kitayama, J,期刊:Anticancer Research, 页码:865-872 , 文章类型: Article,,卷期:2012年32-3]
- Background: Cancer cells can acquire resistance to therapy under hypoxic condition. We aimed to investigate the mechanisms regulating chemoresistance induced by hypoxia. Materials and Methods: Human colorectal cancer cel...
- The Role of Canonical WNT Signaling Pathway in Oral Carcinogenesis: A Comprehensive Review
[作者:Noguti, J; De Moura, CFG; Hossaka, TA; Franco, M; Oshima, CTF; Dedivitis, RA; Ribeiro, DA,期刊:Anticancer Research, 页码:873-878 , 文章类型: Review,,卷期:2012年32-3]
- Oral cancer is a common neoplasm worldwide. The incidence and mortality have also increased in recent decades. It is characterized by poor prognosis and a low survival rate despite sophisticated surgical and radiotherape...
- Decreased Levels of Histone H3K9me1 Indicate Poor Prognosis in Patients with Renal Cell Carcinoma
[作者:Rogenhofer, S; Kahl, P; Holzapfel, S; Von Ruecker, A; Mueller, SC; Ellinger, J,期刊:Anticancer Research, 页码:879-886 , 文章类型: Article,,卷期:2012年32-3]
- Background/Aim: To determine the role of global histone H3K9 and H4K20 methylation levels as prognostic parameters in patients with renal cell cancer (RCC). Material and Methods: Global histone methylation levels were in...
- Cytotoxicity of Activated Natural Killer Cells and Expression of Adhesion Molecules in Small-cell Lung Cancer
[作者:Tsuchida, T; Yamane, H; Ochi, N; Tabayashi, T; Hiraki, A; Nogami, N; Takigawa, N; Kiura, K; Tanimoto, M,期刊:Anticancer Research, 页码:887-892 , 文章类型: Article,,卷期:2012年32-3]
- Background/Aim: Although small-cell lung cancer (SCLC) is sensitive to anticancer agents, most patients with SCLC experience relapse and die within two years. Here, we examined the relationship between natural killer (NK...
- CSF-1R Up-regulation Is Associated with Response to Pharmacotherapy Targeting Tyrosine Kinase Activity in AML Cell Lines
[作者:Kogan, M; Fischer-Smith, T; Kaminsky, R; Lehmicke, G; Rappaport, J,期刊:Anticancer Research, 页码:893-899 , 文章类型: Article,,卷期:2012年32-3]
- Background: The oncogenic potential of colony stimulating factor 1 receptor (CSF-1R) has been well described, while its relevance for human acute myelogenous leukemia (AML) is still undetermined. In a recent clinical tri...
- Expression of Cathepsin-D in Primary Breast Cancer and Corresponding Local Recurrence or Metastasis: An Immunohistochemical Study
[作者:Dian, D; Vrekoussis, T; Shabani, N; Mylonas, I; Kuhn, C; Schindlbeck, C; Navrozoglou, I; Friese, K; Makrigiannakis, A; Jeschke, U,期刊:Anticancer Research, 页码:901-905 , 文章类型: Article,,卷期:2012年32-3]
- Background/Aim: The role of cathepsin-D is well established in breast cancer progression, being correlated with worse clinical outcomes. However, to our knowledge, no study has been performed investigating its expression...
- Silencing of CCDC6 Reduces the Expression of 14-3-3 sigma in Colorectal Carcinoma Cells
[作者:Thanasopoulou, A; Xanthopoulou, AG; Anagnostopoulos, AK; Konstantakou, EG; Margaritis, LH; Papassideri, SS; Stravopodis, DJ; Tsangaris, GT; Anastasiadou, E,期刊:Anticancer Research, 页码:907-913 , 文章类型: Article,,卷期:2012年32-3]
- Coiled-coil domain containing 6 (CCDC6) is frequently rearranged in papillary thyroid carcinomas participating in the formation of RET/PTC1 oncogene. Other rearrangements involving CCDC6 have also been identified demonst...
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