- Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation
[作者:Zhou, Y; Jiang, X; Gu, PY; Chen, WQ; Zeng, XS; Gao, X,期刊:American Journal of Pathology, 页码:763-774 , 文章类型: Article,,卷期:2012年180-2]
- Primary cicatricial alopecias (PCAs) are a group of permanent hair loss disorders, of which the pathogenesis is still poorly understood. The alopecia and excoriation (AE) mouse strain is a dominant mutant generated from ...
- Adenosine A(2A) Receptor Ligation Inhibits Osteoclast Formation
[作者:Mediero, A; Kara, FM; Wilder, T; Cronstein, BN,期刊:American Journal of Pathology, 页码:775-786 , 文章类型: Article,,卷期:2012年180-2]
- Adenosine is generated in increased concentrations at sites of injury/hypoxia and mediates a variety of physiological and pharmacological effects via G protein coupled receptors (A(1), A(2A), A(2B), and A(3)). Because al...
- Compression-Induced Muscle Injury in Rats That Mimics Compartment Syndrome in Humans
[作者:Criswell, TL; Corona, BT; Ward, CL; Miller, M; Patel, M; Wang, Z; Christ, GJ; Soker, S,期刊:American Journal of Pathology, 页码:787-797 , 文章类型: Article,,卷期:2012年180-2]
- Compartment syndrome (CS) is a serious complication arising from a variety of extremity injuries and resultant swelling within the fascicles of the muscle tissue. The current standard of care for CS is fasciotomy, which ...
- Antibodies against Muscle-Specific Kinase Impair Both Presynaptic and Postsynaptic Functions in a Murine Model of Myasthenia Gravis
[作者:Mori, S; Kubo, S; Akiyoshi, T; Yamada, S; Miyazaki, T; Hotta, H; Desaki, J; Kishi, M; Konishi, T; Nishino, Y; Miyazawa, A; Maruyama, N; Shigemoto, K,期刊:American Journal of Pathology, 页码:798-810 , 文章类型: Article,,卷期:2012年180-2]
- Antibodies against acetylcholine receptors (AChRs) cause pathogenicity in myasthenia gravis (MG) patients through complement pathway-mediated destruction of postsynaptic membranes at neuromuscular junctions (NMJs). Howev...
- A Novel Population of Cells Expressing Both Hematopoietic and Mesenchymal Markers Is Present in the Normal Adult Bone Marrow and Is Augmented in a Murine Model of Marrow Fibrosis
[作者:Ohishi, M; Ono, W; Ono, N; Khatri, R; Marzia, M; Baker, EK; Root, SH; Wilson, TL; Iwamototo, Y; Kronenberg, HM; Aguila, HL; Purton, LE; Schipani, E,期刊:American Journal of Pathology, 页码:811-818 , 文章类型: Article,,卷期:2012年180-2]
- Bone marrow (BM) fibrosis is a feature of severe hyperparathyroidism. Consistent with this observation, mice expressing constitutively active parathyroid hormone (PTH)/PTH-related peptide receptors (PPR) in osteoblasts (...
- Reciprocal Induction of Simple Organogenesis by Mouse Kidney Progenitor Cells in Three-Dimensional Co-Culture
[作者:Velagapudi, C; Nilsson, RP; Lee, MJ; Burns, HS; Ricono, JM; Arar, M; Barnes, VL; Abboud, HE; Barnes, JL,期刊:American Journal of Pathology, 页码:819-830 , 文章类型: Article,,卷期:2012年180-2]
- Kidney development is regulated by a coordinated reciprocal induction of metanephric mesenchymal (MM) and ureteric bud (UB) cells. Here, established MM and UB progenitor cell lines were recombined in three-dimensional Ma...
- Ets-1 Activates Overexpression of JunB and CD30 in Hodgkin's Lymphoma and Anaplastic Large-Cell Lymphoma
[作者:Watanabe, M; Itoh, K; Togano, T; Kadin, ME; Watanabe, T; Higashihara, M; Horie, R,期刊:American Journal of Pathology, 页码:831-838 , 文章类型: Article,,卷期:2012年180-2]
- Overexpression of CD30 and JunB is a hallmark of tumor cells in Hodgkin's lymphoma (HL) and anaplastic large-cell lymphoma (ALCL). We reported that CD30-extracellular signal-regulated kinase (ERK)1/2 mitogen-activated pr...
- FOXA1 Promotes Tumor Progression in Prostate Cancer and Represents a Novel Hallmark of Castration-Resistant Prostate Cancer
[作者:Gerhardt, J; Montani, M; Wild, P; Beer, M; Huber, F; Hermanns, T; Muntener, M; Kristiansen, G,期刊:American Journal of Pathology, 页码:848-861 , 文章类型: Article,,卷期:2012年180-2]
- Forkhead box protein A1 (FOXA1) modulates the transactivation of steroid hormone receptors and thus may influence tumor growth and hormone responsiveness in prostate cancer. We therefore investigated the correlation of F...
- Radiation-Induced Increase in Cell Migration and Metastatic Potential of Cervical Cancer Cells Operates Via the K-Ras Pathway
[作者:Su, WH; Chuang, PC; Huang, EY; Yang, KD,期刊:American Journal of Pathology, 页码:862-871 , 文章类型: Article,,卷期:2012年180-2]
- Radiotherapy is a well established treatment for cervical cancer, the second most common cancer in women worldwide. However, metastasis often circumvents the efficacy of radiotherapy. This study was conducted to elucidat...
- Age-Dependent Changes in the Cerebrospinal Fluid Proteome by Slow Off-Rate Modified Aptamer Array
[作者:Baird, GS; Nelson, SK; Keeney, TR; Stewart, A; Williams, S; Kraemer, S; Peskind, ER; Montine, TJ,期刊:American Journal of Pathology, 页码:446-456 , 文章类型: Article,,卷期:2012年180-2]
- An important precondition for the successful development of diagnostic assays of cerebrospinal fluid (CSF) biomarkers of age-related neurodegenerative diseases is an understanding of the dynamic nature of the CSF proteom...
- Differentiation-Promoting Culture of Competent and Noncompetent Keratinocytes Identifies Biomarkers for Head and Neck Cancer
[作者:Ceder, R; Haig, Y; Merne, M; Hansson, A; Zheng, X; Roberg, K; Nees, M; Iljin, K; Bloor, BK; Morgan, PR; Fadeel, B; Grafstrom, RC,期刊:American Journal of Pathology, 页码:457-472 , 文章类型: Article,,卷期:2012年180-2]
- Aberrant contact-inhibited proliferation and differentiation induction couple with tumor severity, albeit with an imprecise association with prognosis. Assessment of contact inhibition and differentiation-promoting cultu...
- Sec62 Bridges the Gap from 3q Amplification to Molecular Cell Biology in Non-Small Cell Lung Cancer
[作者:Linxweiler, M; Linxweiler, J; Barth, M; Benedix, J; Jung, V; Kim, YJ; Bohle, RM; Zimmermann, R; Greiner, M,期刊:American Journal of Pathology, 页码:473-483 , 文章类型: Article,,卷期:2012年180-2]
- The molecular carcinogenesis of lung cancer has yet to be clearly elucidated. We investigated the possible oncogenic function of SEC62 in lung cancer, which was predicted based on our previous findings that lung and thyr...
- Participation of miR-200 in Pulmonary Fibrosis
[作者:Yang, SZ; Banerjee, S; de Freitas, A; Sanders, YY; Ding, Q; Matalon, S; Thannickal, VJ; Abraham, E; Liu, G,期刊:American Journal of Pathology, 页码:484-493 , 文章类型: Article,,卷期:2012年180-2]
- Excessive extracellular matrix production by fibroblasts in response to tissue injury contributes to fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF). Epithelial-mesenchymal transition, involving transition...
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