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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosohate Mimic [作者：YIN ZHOU; SONG YUNLONG; REHSE PETER H,期刊：ACS CHEMICAL BIOLOGY, 页码：303-308 , 文章类型： Article，,卷期：2013年8-2] Phosphorylation-dependent protein-protein interaction has rarely been targeted in medicinal chemistry. Thymoquinone, a naturally occurring antitumor agent, disrupts prephosphorylated substrate recognition by the polo-box... Chemical Detoxification of Small Molecules by Caenorhabditis elegans [作者：STUPP GREGORY S; VON REUSS STEPHAN H; IZRAYELIT YEVGENIY; AJREDINI RAMADAN; SCHROEDER FRANK C; EDISON ARTHUR S,期刊：ACS CHEMICAL BIOLOGY, 页码：309-313 , 文章类型： Article，,卷期：2013年8-2] Caenorhabditis elegans lives in compost and decaying fruit, eats bacteria and is exposed to pathogenic microbes. We show that C. elegans is able to modify diverse microbial small-molecule toxins via both O- and N-glucosy... 2D NMR-Based Metabolomics Uncovers Interactions between Conserved Biochemical Pathways in the Model Organism Caenorhabditis elegans [作者：IZRAYELIT YEVGENIY; ROBINETTE STEVEN L; BOSE NEELANJAN; VON REUSS STEPHAN H; SCHROEDER FRANK C,期刊：ACS CHEMICAL BIOLOGY, 页码：314-319 , 文章类型： Article，,卷期：2013年8-2] Ascarosides are small-molecule signals that play a central role in C. elegans biology, including dauer formation, aging, and social behaviors, but many aspects of their biosynthesis remain unknown. Using automated 2D NMR... Electrostatically Controlled Quantum Dot Monofunctionalization for Interrogating the Dynamics of Protein Complexes in Living Cells [作者：YOU CHANGJIANG; WILMES STEPHAN; RICHTER CHRISTIAN P; BEUTEL OLIVER; LISSE DOMENIK; PIEHLER JACOB,期刊：ACS CHEMICAL BIOLOGY, 页码：320-326 , 文章类型： Article，,卷期：2013年8-2] Quantum dots (QD) are powerful labels for probing diffusion and interaction dynamics of proteins on the single molecule level in living cells. Protein cross-linking due to multifunctional QD strongly affects these proper... Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-ca rboxylate (CXL017): A Novel Scaffold That Resensitizes Multidrug Resistant Leukemia Cells to Chemotherapy [作者：DAS SONIA G; HERMANSON DAVID L; BLEEKER NICHOLAS; LOWMAN XAZMIN; LI YUNFANG; KELEKAR AMEETA; XING CHENGGUO,期刊：ACS CHEMICAL BIOLOGY, 页码：327-335 , 文章类型： Article，,卷期：2013年8-2] Multidrug resistance (MDR) is a major hurdle in the treatment of cancer, and there is a pressing need for new therapies. We have recently developed ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromen... Human DNA Polymerase beta, but Not lambda, Can Bypass a 2-Deoxyribonolactone Lesion Together with Proliferating Cell Nuclear Antigen [作者：CRESPAN EMMANUELE; PASI EMANUELA; IMOTO SHUHEI; HUEBSCHER ULRICH; GREENBERG MARC M; MAGA GIOVANNI,期刊：ACS CHEMICAL BIOLOGY, 页码：336-344 , 文章类型： Article，,卷期：2013年8-2] The C1'-oxidized lesion 2-deoxyribonolactone (L) is induced by free radical attack of DNA. This lesion is mutagenic, inhibits base excision repair, and can lead to strand scission. In double-stranded DNA L is repaired by... Antitumor Effects of EGFR Antisense Guanidine-Based Peptide Nucleic Acids in Cancer Models [作者：THOMAS SUFI M; SAHU BICHISMITA; RAPIREDDY SRINIVAS; BAHAL RAMAN; WHEELER SARAH E; PROCOPIO EVA M; KIM JOSEPH; JOYCE SONALI C; CONTRUCCI SARAH; WANG YUN; CHIOSEA SIMION I; LATHROP KIRA L; WATKINS SIMON; GRANDIS JENNIFER R; ARMITAGE BRUCE A; LY DANITH H,期刊：ACS CHEMICAL BIOLOGY, 页码：345-352 , 文章类型： Article，,卷期：2013年8-2] Peptide nucleic acids have emerged over the past two decades as a promising class of nucleic acid mimics because of their strong binding affinity and sequence selectivity toward DNA and RNA, and resistance to enzymatic d...