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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共31条记录   A Short DNA Aptamer That Recognizes TNF alpha and Blocks Its Activity in Vitro [作者：ORAVA ERIK W; JARVIK NICK; SHEK YUEN LAI; SIDHU SACHDEV S; GARIEPY JEAN,期刊：ACS CHEMICAL BIOLOGY, 页码：170-178 , 文章类型： Article，,卷期：2013年8-1] Tumor necrosis factor-alpha (TNF alpha) is a pivotal component of the cytokine network linked to inflammatory diseases. Protein-based, TNF alpha inhibitors have proven to be clinically valuable. Here, we report the ident... Site-Specific Noncovalent Interaction of the Biopolymer Poly(ADP-ribose) with the Werner Syndrome Protein Regulates Protein Functions [作者：POPP OLIVER; VEITH SEBASTIAN; FAHRER JOERG; BOHR VILHELM A; BUERKLE ALEXANDER; MANGERICH ASWIN,期刊：ACS CHEMICAL BIOLOGY, 页码：179-188 , 文章类型： Article，,卷期：2013年8-1] Werner syndrome is a premature aging disorder that is caused by defects in the Werner protein (WRN). WRN is a member of the RecQ helicase family and possesses helicase and exonuclease activities. It is involved in variou... Metabolic Footprinting of Mutant Libraries to Map Metabolite Utilization to Genotype [作者：BARAN RICHARD; BOWEN BENJAMIN P; PRICE MORGAN N; ARKIN ADAM P; DEUTSCHBAUER ADAM M; NORTHEN TRENT R,期刊：ACS CHEMICAL BIOLOGY, 页码：189-199 , 文章类型： Article，,卷期：2013年8-1] The discrepancy between the pace of sequencing and functional characterization of genomes is a major challenge in understanding complex microbial metabolic processes and metabolic interactions in the environment. Here, w... Diversity of Allosteric Regulation in Proteases [作者：MERDANOVIC MELISA; MOENIG TIMON; EHRMANN MICHAEL; KAISER MARKUS,期刊：ACS CHEMICAL BIOLOGY, 页码：19-26 , 文章类型： Review，,卷期：2013年8-1] Allostery is a fundamental regulatory mechanism that is based on a functional modulation of a site by a distant site. Allosteric regulation can be triggered by binding of diverse allosteric effectors, ranging from small ... Poly Specific trans-Acyltransferase Machinery Revealed via Engineered Acyl-CoA Synthetases [作者：KORYAKINA IRINA; MCARTHUR JOHN; RANDALL SHAN; DRAELOS MATTHEW M; MUSIOL EWA M; MUDDIMAN DAVID C; WEBER TILMANN; WILLIAMS GAVIN J,期刊：ACS CHEMICAL BIOLOGY, 页码：200-208 , 文章类型： Article，,卷期：2013年8-1] Polyketide synthases construct polyketides with diverse structures and biological activities via the condensation of extender units and acyl thioesters. Although a growing body of evidence suggests that polyketide syntha... Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1H-isoindole Derivatives, Inhibitors of HIV-1 lntegrase [作者：METIFIOT MATHIEU; MADDALI KASTHURAIAH; JOHNSON BARRY C; HARE STEPHEN; SMITH STEVEN J; ZHAO XUE ZHI; MARCHAND CHRISTOPHE; BURKE TERRENCE R JR; HUGHES STEPHEN H; CHEREPANOV PETER; POMMIER YVES,期刊：ACS CHEMICAL BIOLOGY, 页码：209-217 , 文章类型： Article，,卷期：2013年8-1] On the basis of a series of lactam and phthalimide derivatives that inhibit HIV-1 integrase, we developed a new molecule, XZ-259, with biochemical and antiviral activities comparable to raltegravir. We determined the cry... MARCKS-ED Peptide as a Curvature and Lipid Sensor [作者：MORTON LESLIE A; YANG HENGWEN; SALUDES JONEL P; FIORINI ZENO; BENINSON LIDA; CHAPMAN EDWIN R; FLESHNER MONIKA; XUE DING; YIN HANG,期刊：ACS CHEMICAL BIOLOGY, 页码：218-225 , 文章类型： Article，,卷期：2013年8-1] Membrane curvature and lipid composition regulates important biological processes within a cell. Currently, several proteins have been reported to sense and/or induce membrane curvatures, e.g., Synaptotagmin-1 and Amphip... Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to beta-Lactams [作者：FARHA MAYA A; LEUNG ALEXANDER; SEWELL EDWARD W; DELIA MICHAEL A; ALLISON SARAH E; EJIM LINDA; PEREIRA PEDRO M; PINHO MARIANA G; WRIGHT GERARD D; BROWN ERIC D,期刊：ACS CHEMICAL BIOLOGY, 页码：226-233 , 文章类型： Article，,卷期：2013年8-1] Rising drug resistance is limiting treatment options for infections by methicillin-resistant Staphylococcus aureus (MRSA). Herein we provide new evidence that wall teichoic acid (WTA) biogenesis is a remarkable antibacte... Development of a 2,4-Dinitrotoluene-Responsive Synthetic Riboswitch in E. coli Cells [作者：DAVIDSON MOLLY E; HARBAUGH SVETLANA V; CHUSHAK YAROSLAV G; STONE MORLEY O; KELLEYLOUGHNANE NANCY,期刊：ACS CHEMICAL BIOLOGY, 页码：234-241 , 文章类型： Article，,卷期：2013年8-1] Riboswitches are RNA sequences that regulate expression of associated downstream genes in response to the presence or absence of specific small molecules. A novel riboswitch that activates protein translation in E. coil ... Anthranilate Phosphoribosyl Transferase (TrpD) Generates Phosphoribosylamine for Thiamine Synthesis from Enamines and Phosphoribosyl Pyrophosphate [作者：LAMBRECHT JENNIFER A; DOWNS DIANA M,期刊：ACS CHEMICAL BIOLOGY, 页码：242-248 , 文章类型： Article，,卷期：2013年8-1] Anthranilate phosphoribosyl transferase (TrpD) has been well characterized for its role in the tryptophan biosynthetic pathway. Here, we characterized a new reaction catalyzed by TrpD that resulted in the formation of th... Discovery of Novel Human Aquaporin-1 Blockers [作者：SEELIGER DANIEL; ZAPATER CINTA; KRENC DAWID; HADDOUB ROSE; FLITSCH SABINE; BEITZ ERIC; CERDA JOAN; DE GROOT BERT L,期刊：ACS CHEMICAL BIOLOGY, 页码：249-256 , 文章类型： Article，,卷期：2013年8-1] Human aquaporin-1 (hAQP1) is a water channel found in many tissues and potentially involved in several human pathologies. Selective inhibitors of hAQP1 are discussed as novel treatment opportunities for glaucoma, brain e... Integrated Compound Profiling Screens Identify the Mitochondrial Electron Transport Chain as the Molecular Target of the Natural Products Manassantin, Sesquicillin, and Arctigenin [作者：LAI KEVIN; SELINGER DOUGLAS W; SOLOMON JONATHAN M; WU HUA; SCHMITT ESTHER; SERLUCA FABRIZIO C; CURTIS DANIEL; BENSON JOHN D,期刊：ACS CHEMICAL BIOLOGY, 页码：257-267 , 文章类型： Article，,卷期：2013年8-1] Phenotypic compound screens can be used to identify novel targets in signaling pathways and disease processes, but the usefulness of these screens depends on the ability to quickly determine the target and mechanism of a... Potentiation of the Kv1 family K+ Channel by Cortisone Analogues (vol 7, pg 1641, 2012) [作者：PAN YAPING; LEVIN ELENA J; QUICK MATTHIAS; ZHOU MING,期刊：ACS CHEMICAL BIOLOGY, 页码：268-268 , 文章类型： Correction，,卷期：2013年8-1] Stabilization and Inhibition of Protein Protein Interactions: The 14-3-3 Case Study [作者：MILROY LECHGUSTAV; BRUNSVELD LUC; OTTMANN CHRISTIAN,期刊：ACS CHEMICAL BIOLOGY, 页码：27-35 , 文章类型： Review，,卷期：2013年8-1] Small-molecule modulation of protein-protein interactions (PPIs) is one of the most exciting but also difficult fields in chemical biology and drug development. As one of the most important "hub" proteins with at least 2... Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics [作者：DE MUNTER SOFIE; KOEHN MAJA; BOLLEN MATHIEU,期刊：ACS CHEMICAL BIOLOGY, 页码：36-45 , 文章类型： Review，,卷期：2013年8-1] Protein phosphatases have both protective and promoting roles in the etiology of diseases. A prominent example is the existence of oncogenic as well as tumor-suppressing protein phosphatases. A few protein phosphatase ac...