- N-confused porphyrin possessing glucamine-appendants: Aggregation and acid/base properties in aqueous media
[作者：Ikawa, Y; Ogawa, H; Harada, H; Furuta, H,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6394-6397 , 文章类型： Article，,卷期：2008年18-24]
- A water-soluble derivative of N-confused porphyrin (NCP: 5,10,15,20-tetraaryl-2-aza-21-carbaporphyrin) was synthesized by introducing glucamine groups at the para-position of meso-aryl groups. The tetraglucamine-appended...
- Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology
[作者：Nemoto, T; Fujii, H; Narita, M; Miyoshi, K; Nakamura, A; Suzuki, T; Nagase, H,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6398-6401 , 文章类型： Article，,卷期：2008年18-24]
- A novel 6,14-epoxymorphinan benzamide derivative (NS22) was synthesized, which showed opioid kappa receptor agonistic activity in the [S-35]GTP gamma S binding assay. The antinociceptive effect of NS22 was evaluated in t...
- Mirror Neurons Differentially Encode the Peripersonal and Extrapersonal Space of Monkeys
[作者：Caggiano, V; Fogassi, L; Rizzolatti, G; Thier, P; Casile, A,期刊：Science, 页码：403-406 , 文章类型： Article，,卷期：2009年324-5925]
- Actions performed by others may have different relevance for the observer, and thus lead to different behavioral responses, depending on the regions of space in which they are executed. We found that in rhesus monkeys, t...
- DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity
[作者：Meijsing, SH; Pufall, MA; So, AY; Bates, DL; Chen, L; Yamamoto, KR,期刊：Science, 页码：407-410 , 文章类型： Article，,卷期：2009年324-5925]
- Genes are not simply turned on or off, but instead their expression is fine-tuned to meet the needs of a cell. How genes are modulated so precisely is not well understood. The glucocorticoid receptor (GR) regulates targe...
- Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors
[作者：Alhamadsheh, MM; Waters, NC; Sachdeva, S; Lee, P; Reynolds, KA,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6402-6405 , 文章类型： Article，,卷期：2008年18-24]
- A series of analogs of 2-tosylnaphthalene-1,4-diol were prepared and were found to be potent 10-20 nM reversible inhibitors of the Escherichia coli FabH enzyme. The inhibitors were also effective but to a lesser degree (...
- Chroman-3-amides as potent Rho kinase inhibitors
[作者：Chen, YT; Bannister, TD; Weiser, A; Griffin, E; Lin, L; Ruiz, C; Cameron, MD; Schurer, S; Duckett, D; Schroter, T; LoGrasso, P; Feng, YB,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6406-6409 , 文章类型： Article，,卷期：2008年18-24]
- Inhibition of Rho kinase (ROCK) is an attractive strategy for the treatment of diseases such as hypertension, glaucoma, and cancer. Here we report chroman-3-amides as highly potent ROCK inhibitors with sufficient kinase ...
- Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors
[作者：Ahn, JH; Park, WS; Jun, MA; Shin, MS; Kang, SK; Kim, KY; Dal Rhee, S; Bae, MA; Kim, KR; Kim, SG; Kim, SY; Sohn, SK; Kang, NS; Lee, JO; Lee, DH; Cheon, HG; Kim, SS,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6525-6529 , 文章类型： Article，,卷期：2008年18-24]
- Compounds with homopiperazine skeleton are designed to find a potent DPP-IV inhibitor without inhibiting CYP. Thus a series of beta-aminoacyl-containing homopiperazine derivatives was synthesized and evaluated. Compounds...
- Comment on "Atmospheric Hydroxyl Radical Production from Electronically Excited NO2 and H2O"
[作者：Carr, S; Heard, DE; Blitz, MA,期刊：Science, 页码：U1-U2 , 文章类型： Editorial Material，,卷期：2009年324-5925]
- Li et al. (Reports, 21 March 2008, p. 1657) suggested that the reaction between electronically excited nitrogen dioxide and water vapor is an important atmospheric source of the hydroxyl radical. However, under condition...
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