- Response to Letter Regarding Article, "Trimetazidine, a Metabolic Modulator, Has Cardiac and Extracardiac Benefits in Idiopathic Dilated Cardiomyopathy"
[作者：Tuunanen, H; Knuuti, J; Opie, LH,期刊：Circulation, 页码：E372-E372 , 文章类型： Letter，,卷期：2009年119-11]
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- A Ferroelectric Oxide Made Directly on Silicon
[作者：Warusawithana, MP; Cen, C; Sleasman, CR; Woicik, JC; Li, YL; Kourkoutis, LF; Klug, JA; Li, H; Ryan, P; Wang, LP; Bedzyk, M; Muller, DA; Chen, LQ; Levy, J; Schlom, DG,期刊：Science, 页码：367-370 , 文章类型： Article，,卷期：2009年324-5925]
- Metal oxide semiconductor field-effect transistors, formed using silicon dioxide and silicon, have undergone four decades of staggering technological advancement. With fundamental limits to this technology close at hand,...
- Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions
[作者：Isik, S; Kockar, F; Arslan, O; Guler, OO; Innocenti, A; Supuran, CT,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6327-6331 , 文章类型： Article，,卷期：2008年18-24]
- The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, has been cloned, purified, characterized kinetically, and investigated for its inhibition...
- Carbonic anhydrase inhibitors: 2-Substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV
[作者：Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6332-6335 , 文章类型： Article，,卷期：2008年18-24]
- A series of 2-substituted-1,3,4-thiadiazole-5-sulfamides was prepared and assayed as inhibitors of several carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic CA I and II, the membrane-associated CA IV and the mi...
- Synthesis of BODIPY-labeled alkylphosphocholines with leishmanicidal activity, as fluorescent analogues of miltefosine
[作者：Hornillos, V; Carrillo, E; Rivas, L; Amat-Guerri, F; Acuna, AU,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6336-6339 , 文章类型： Article，,卷期：2008年18-24]
- Two general synthetic methods are described, by which the highly fluorescent and photostable BODIPY group can be inserted in and aligned with the alkyl backbone of linear lipids. These methods have been used to prepare s...
- Structure-activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough
[作者：Yang, SW; Ho, G; Tulshian, D; Greenlee, WJ; Fernandez, X; McLeod, RL; Eckel, S; Anthes, J,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6340-6343 , 文章类型： Article，,卷期：2008年18-24]
- A series of 3-axial-aminomethyl-N-benzhydryl-nortropane analogs have been synthesized and identified to bind to the nociceptin receptor with high affinity. Many of these analogs showed high binding selectivity over class...
- Origin of Nucleosynthetic Isotope Heterogeneity in the Solar Protoplanetary Disk
[作者：Trinquier, A; Elliott, T; Ulfbeck, D; Coath, C; Krot, AN; Bizzarro, M,期刊：Science, 页码：374-376 , 文章类型： Article，,卷期：2009年324-5925]
- Stable-isotope variations exist among inner solar system solids, planets, and asteroids, but their importance is not understood. We report correlated, mass-independent variations of titanium-46 and titanium-50 in bulk an...
- Atlantic Forcing of Persistent Drought in West Africa
[作者：Shanahan, TM; Overpeck, JT; Anchukaitis, KJ; Beck, JW; Cole, JE; Dettman, DL; Peck, JA; Scholz, CA; King, JW,期刊：Science, 页码：377-380 , 文章类型： Article，,卷期：2009年324-5925]
- Although persistent drought in West Africa is well documented from the instrumental record and has been primarily attributed to changing Atlantic sea surface temperatures, little is known about the length, severity, and ...
- Protection of C-elegans from Anoxia by HYL-2 Ceramide Synthase
[作者：Menuz, V; Howell, KS; Gentina, S; Epstein, S; Riezman, I; Fornallaz-Mulhauser, M; Hengartner, MO; Gomez, M; Riezman, H; Martinou, JC,期刊：Science, 页码：381-384 , 文章类型： Article，,卷期：2009年324-5925]
- Oxygen deprivation is rapidly deleterious for most organisms. However, Caenorhabditis elegans has developed the ability to survive anoxia for at least 48 hours. Mutations in the DAF-2/DAF-16 insulin-like signaling pathwa...
- Orally bioavailable prodrugs of a BCS class 2 molecule, an inhibitor of HIV-1 reverse transcriptase
[作者：Elworthy, TR; Dunn, JP; Hogg, JH; Lam, G; Saito, YD; Silva, TMPC; Stefanidis, D; Woroniecki, W; Zhornisky, E; Zhou, AS; Klumpp, K,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6344-6347 , 文章类型： Article，,卷期：2008年18-24]
- The N-2 position of pyridazinone 1, a potent HIV-1 NNRTI that has limited aqueous solubility, was derivatized into a series of hydroxymethyl esters and carbonates as well as one phosphate. The derivatives served as prodr...
- Identification and optimization of N-3,N-6-diaryl-1H-pyrazolo[3,4-d] pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors
[作者：Kopecky, DJ; Hao, XL; Chen, Y; Fu, JS; Jiao, XY; Jaen, JC; Cardozo, MG; Liu, JS; Wang, ZL; Walker, NPC; Wesche, H; Li, S; Farrelly, E; Xiao, SH; Kayser, F,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6352-6356 , 文章类型： Article，,卷期：2008年18-24]
- A new series of pyrazolo[3,4-d] pyrimidine-3,6-diamines was designed and synthesized as potent and selective inhibitors of the nonreceptor tyrosine kinase, ACK1. These compounds arose from efforts to rigidify an earlier ...
- Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists
[作者：Bharate, SB; Rodge, A; Joshi, RK; Kaur, J; Srinivasan, S; Kumar, SS; Kulkarni-Almeida, A; Balachandran, S; Balakrishnan, A; Vishwakarma, RA,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6357-6361 , 文章类型： Article，,卷期：2008年18-24]
- In this letter, we report discovery of diacylphloroglucinol compounds as a new class of GPR40 (FFAR1) agonists. Several diacylphloroglucinols with varying length of acyl functionality and substitution on aromatic hydroxy...
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