- G-Protein-Coupled Receptor Kinase Interacting Protein-1 Is Required for Pulmonary Vascular Development
[作者:Pang, JJ; Hoefen, R; Pryhuber, GS; Wang, J; Yin, GY; White, RJ; Xu, XB; O'Dell, MR; Mohan, A; Michaloski, H; Massett, MP; Yan, C; Berk, BC,期刊:Circulation, 页码:1524-U120 , 文章类型: Article,,卷期:2009年119-11]
- Background-The G-protein-coupled receptor kinase interacting protein-1 (GIT1) is a multidomain scaffold protein that participates in many cellular functions including receptor internalization, focal adhesion remodeling, ...
- cis-Nitromethylene neonicotinoids as new nicotinic family: Synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2-alpha]pyridine
[作者:Shao, XS; Zhang, WW; Peng, YQ; Li, Z; Tian, ZZ; Qian, XH,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:6513-6516 , 文章类型: Article,,卷期:2008年18-24]
- A series of neonicotinoids analogues of hexahydroimidazo[1,2-alpha]pyridine were modified at 5-, 6-, and 7-positions, and their insecticidal activities were evaluated. Introducing a methyl or ethyl at 7-position increase...
- Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum
[作者:Martyn, DC; Ramirez, AP; Berattie, MJ; Cortese, JF; Patel, V; Rush, MA; Woerpel, KA; Clardy, J,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:6521-6524 , 文章类型: Article,,卷期:2008年18-24]
- Artemisinin-derived compounds play an integral role in current malaria chemotherapy. Given the virtual certainty of emerging resistance, we have investigated spiro-1,2-dioxolanes as an alternative scaffold. The endoperox...
- Prevention of Rheumatic Fever and Diagnosis and Treatment of Acute Streptococcal Pharyngitis A Scientific Statement From the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young, the Interdisciplinary Council on Functional Genomics and Translational Biology, and the Interdisciplinary Council on Quality of Care and Outcomes Research Endorsed by the American Academy of Pediatrics
[作者:Gerber, MA; Baltimore, RS; Eaton, CB; Gewitz, M; Rowley, AH; Shulman, ST; Taubert, KA,期刊:Circulation, 页码:1541-1551 , 文章类型: Article,,卷期:2009年119-11]
- Primary prevention of acute rheumatic fever is accomplished by proper identification and adequate antibiotic treatment of group A beta-hemolytic streptococcal (GAS) tonsillopharyngitis. Diagnosis of GAS pharyngitis is be...
- Posttraumatic Cardiac Contrecoup In Vivo Evidence by Cardiac Magnetic Resonance Imaging
[作者:Moccetti, M; Wyttenbach, R; Santini, P; Previsdomini, M; Corti, R; Gallino, A,期刊:Circulation, 页码:1538-1540 , 文章类型: Editorial Material,,卷期:2009年119-11]
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- Synthesis of 3,6-bicyclolides: A novel class of macrolide antibiotics
[作者:Gai, YH; Tang, DT; Xu, GY; Chen, ZG; Polemeropoulos, A; Wang, Z; Or, YS,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:6315-6318 , 文章类型: Article,,卷期:2008年18-24]
- The synthesis of 3,6-bicyclolides from erythromycin A oxime is described. This novel class of bridged bicyclic macrolides demonstrates potent in vitro and in vivo activities against a broad spectrum of bacteria including...
- Leucettamol A: A new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. microrhaphis
[作者:Tsukamoto, S; Takeuchi, T; Rotinsulu, H; Mangindaan, REP; van Soest, RWM; Ukai, K; Kobayashi, H; Namikoshi, M; Ohta, T; Yokosawa, H,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:6319-6320 , 文章类型: Article,,卷期:2008年18-24]
- A compound that inhibits the formation of a complex composed of the ubiquitin E2 enzyme Ubc13 and Uev1A was isolated from the marine sponge Leucetta aff. microrhaphis. The compound was identified as leucettamol A (1) by ...
- New cyclic tetrapeptides from Nonomuraea sp TA-0426 that inhibit glycine transporter type 1 (GlyT1)
[作者:Terui, Y; Yi-wen, C; Jun-ying, L; Ando, T; Fukunaga, T; Aoki, T; Toda, Y,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:6321-6323 , 文章类型: Article,,卷期:2008年18-24]
- In the course of our search for natural antipsychotic agents, we isolated five new cyclic tetrapeptides from the fermentation broth of Nonomuraea sp. TA-0426. These compounds turned out to be analogues of WSS2220, which ...
- Vasodilatation effect of farnesylacetones, active constituents of Sargassum siliquastrum, on the basilar and carotid arteries of rabbits
[作者:Park, BG; Kwon, SC; Park, GM; Ham, J; Shin, WS; Lee, S,期刊:Bioorganic & Medicinal Chemistry Letters, 页码:6324-6326 , 文章类型: Article,,卷期:2008年18-24]
- Two farnesylacetones, 311 and 312, major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, showed a moderate vasodilatation effect on the basilar arteries of rabbits. Theref...
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