A novel pH activatable near-infrared fluorescence probe was developed, which successfully visualized acidosis in tumors. This probe holds promise to non-invasively predict the tumor metastasis potential and evaluate the ...
An efficient method for synthesis of anthranilic acids by Pd-catalyzed ortho-C-H amidation of benzoic acids is disclosed. The amidation is proposed to proceed by carboxylate-assisted ortho-C-H palladation to form an aryl...
The presence of water or organic solvent vapour accelerates the solid-state condensation of solid aromatic amines and aromatic aldehydes into Schiff bases; we show the important role of catalytic triethylamine in the vap...
The synthesis of 1-methyl-3-(arylthio)-1H-indoles has been achieved by the photoredox reaction of N-methylindoles with readily available arylsulfonyl chlorides in moderate yields.
Eighteen Cu(II) ions are consolidated by simple inorganic linkers alone to construct an S-6-symmetric six-bladed impeller-like Cu-18 nanocluster driven by the concomitant decomposition reaction of a Schiff base, which af...
A ferredoxin associated with biological Fe-S cluster assembly has been remodelled to transfer electrons to a P450 enzyme and support substrate oxidation at 80% of the physiological ferredoxin activity, opening up the pos...
The design of an imidazole-based salt by enzyme-mimicking allowed controlling the ring-opening polymerization of L- and D-LA monomers in bulk. Kinetic study supports a bifunctional activation process only slightly differ...
Recent conceptual advances in the chemical synthesis of peptide constructs are described, encompassing native chemical ligation (i.e. the chemoselective covalent condensation of unprotected peptide segments) and O-, S-ac...
Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation...
Zirconocene dichloride (Cp2ZrCl2) has been shown to be an effective catalyst for the transamidation of primary amides with amines in cyclohexane at 80 degrees C in 5-24 hours. For favourable substrates, the reaction can ...
The title compound was synthesised in a concise route (nine linear steps, 31% overall yield) employing an alpha-silyl epoxide ring opening, a Julia-Kocienski olefination and a late-stage Peterson elimination as key steps...
Organosulphur compounds can be easily and selectively oxidized to sulfones using a small excess of Oxone (R) (1.6 eq.) under solventless mechanical milling conditions. This green procedure has been efficiently applied to...
Continuous CaCO3 hollow nanoparticle generation at room temperature with simultaneous molecule doping is realized on a liquid-gas dual phase microfluidic system.
Lignosulfonates, which are byproducts of the pulp and paper industry, can be used as promoters for the formation of methane hydrates with a high capacity up to 170 v/v and a high formation rate.
An air-stable photoresponsive viologen molecular system is constructed based on a three-fold accordion interpenetrating packing arrangement. The fluorescent modulation process is coupled with a photochromic reaction via ...
A highly efficient macrocyclization reaction has been developed via the palladium-catalyzed C-H arylation of the side-chains of tryptophan with halophenyl-containing amino acids. This method allows for direct access to 1...