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  • Synthesis and biological evaluation of novel 3 '-difluorovinyl taxoids
    [作者:KUZNETSOVA LARISSA; SUN LIANG; CHEN JIN; ZHAO XIANRUI; SEITZ JOSHUA; DAS MANISHA; LI YUAN; VEITH JEAN M; PERA PAULA; BERNACKI RALPH J; XIA SHUJUN; HORWITZ SUSAN B; OJIMA IWAO,期刊:Journal of Fluorine Chemistry, 页码:177-188 , 文章类型: Article,,卷期:2012年143-11]
  • A series of 3'-difluorovinyl taxoids with C10 modifications, as well as those with C2 and C10 modifications, were strategically designed to block the metabolism by cytochrome P-450 3A4 enzyme and synthesized. These novel...