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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共6条记录   Synthesis of Nicotinamide Derivatives Having a Hydroxy-Substituted Benzene Ring and the Influence of Their Structures on the Apoptosis-Inducing Activity Against Leukemia Cells [作者：Yamaguchi, T; Matsumura, Y; Ishii, T; Tokuoka, Y; Kurita, K,期刊：Drug Development Research, 页码：289-297 , 文章类型： Article，,卷期：2011年72-3] With the view of developing novel apoptosis-inducing agents against malignant cells, nicotinamide derivatives containing substituted O-benzoyl-tyrosine, dopamine, and norepinephrine residues were synthesized. Antiprolife... Preparation and Characterization of Chitosan Microparticles for Oral Sustained Delivery of Gliclazide: In Vitro/In Vivo Evaluation [作者：Barakat, NS; Almurshedi, AS,期刊：Drug Development Research, 页码：235-246 , 文章类型： Article，,卷期：2011年72-3] Chitosan microparticles were prepared with tripolyphosphate (TPP) by ionic cross-linking with gliclazide (GLZ) as a model drug. The particle sizes of TPP-chitosan microparticles ranged from 675-887 mu m with loading effi... Regioselective Synthesis of 3-(1H-indol-3-yl)-5-(1H-indole-3-carbonyl)-4-hydroxyfuroic Acids: Route to Hydroxyfuroic Acid-Based Insulin Receptor Activators [作者：Chou, SY; Tsai, HJ,期刊：Drug Development Research, 页码：247-258 , 文章类型： Article，,卷期：2011年72-3] A new class of insulin receptor activator with a hydroxyfuroic acid in place of a hydroxyquinone moiety is reported. The synthesis of 3-(1H-indol-3-yl)-5-(1H-indole-3-carbonyl)-4-hydroxyfuroic acids (26-30) requires seve... 3-Butyl-6-Fluoro-1 (3H)-Isobenzofuranone, A Derivative of dl-n-Butylphthalide, Attenuates Hydrogen Peroxide-Induced Damage in PC12 Cells [作者：Xu, L; Ji, MX; Zhao, N; Ji, BS,期刊：Drug Development Research, 页码：259-264 , 文章类型： Article，,卷期：2011年72-3] The anti-cerebral ischemia agent, dl-3-n-butylphthalide (NBP), is effective in models of vascular dementia in animals. The present study investigates the protective effect of 3-butyl-6-fluoro-1 (3H)-isobenzofuranone (6-F... Liposomes for Enhanced Cytotoxic Activity of Bleomycin [作者：Alomrani, AH; El Maghraby, GM; Alanazi, FK; Al-Mohanna, MA; Alaiya, AA; Alsarra, IA,期刊：Drug Development Research, 页码：265-273 , 文章类型： Article，,卷期：2011年72-3] The purpose of this study was to investigate the effect of liposome composition, which affects the nature of vesicular membrane on the cytotoxic efficacy of bleomycin. Formulation A comprised phosphatidylcholine (PC), ch... Synthesis and Evaluation as PDE4 Inhibitors of Pyrimidine-2,4-dione Derivatives [作者：Giovannoni, MP; Graziano, A; Matucci, R; Nesi, M; Cesari, N; Vergelli, C; Biancalani, C; Crocetti, L; Cilibrizzi, A; Dal Piaz, V,期刊：Drug Development Research, 页码：274-288 , 文章类型： Article，,卷期：2011年72-3] A series of nitraquazone analogs with a pyrimidindione core was synthesized and tested for inhibitory activity on PDE4, selectivity versus PDE3 and PDE5 and for affinity towards the rolipram high-affinity binding site (H...