- p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity
[作者:Baeza-Raja, B; Li, PP; Le Moan, N; Sachs, BD; Schachtrup, C; Davalos, D; Vagena, E; Bridges, D; Kim, C; Saltiel, AR; Olefsky, JM; Akassoglou, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5838-5843 , 文章类型: Article,,卷期:2012年109-15]
- Insulin resistance is a key factor in the etiology of type 2 diabetes. Insulin-stimulated glucose uptake is mediated by the glucose transporter 4 (GLUT4), which is expressed mainly in skeletal muscle and adipose tissue. ...
- Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates
[作者:Xue, L; Wang, WH; Iliuk, A; Hu, LH; Galan, JA; Yu, S; Hans, M; Geahlen, RL; Tao, WA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5615-5620 , 文章类型: Article,,卷期:2012年109-15]
- Our understanding of the molecular control of many disease pathologies requires the identification of direct substrates targeted by specific protein kinases. Here we describe an integrated proteomic strategy, termed kina...
- The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
[作者:Cross, BCS; Bond, PJ; Sadowski, PG; Jha, BK; Zak, J; Goodman, JM; Silverman, RH; Neubert, TA; Baxendale, IR; Ron, D; Harding, HP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E869-E878 , 文章类型: Article,,卷期:2012年109-15]
- IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the regulated degradation of diverse membrane-bound mRNAs. We repor...
- Late Jurassic salamandroid from western Liaoning, China
[作者:Gao, KQ; Shubin, NH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5767-5772 , 文章类型: Article,,卷期:2012年109-15]
- A Jurassic salamander, Beiyanerpeton jianpingensis (gen. et sp. nov.), from a recently found site in western Liaoning Province, China is the earliest known record of Salamandroidea. As a Late Jurassic record of the group...
- Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2(+):ER alpha(-) breast cancer
[作者:Liu, JC; Voisin, V; Bader, GD; Deng, T; Pusztai, L; Symmans, WF; Esteva, FJ; Egan, SE; Zacksenhaus, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5832-5837 , 文章类型: Article,,卷期:2012年109-15]
- Human Epidermal Growth Factor Receptor 2-positive (HER2(+)) breast cancer (BC) is a highly aggressive disease commonly treated with chemotherapy and anti-HER2 drugs, including trastuzumab. There is currently noway to pre...
- Sex, puberty, and the timing of sleep EEG measured adolescent brain maturation
[作者:Campbell, IG; Grimm, KJ; de Bie, E; Feinberg, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5740-5743 , 文章类型: Article,,卷期:2012年109-15]
- The steep adolescent decline in the slow wave (delta, 1-4 Hz) electroencephalogram (EEG) of nonrapid eye movement (NREM) sleep is a dramatic maturational change in brain electrophysiology thought to be driven by cortical...
- Dichotomous effects of VEGF-A on adipose tissue dysfunction
[作者:Sun, K; Asterholm, IW; Kusminski, CM; Bueno, AC; Wang, ZV; Pollard, JW; Brekken, RA; Scherer, PE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5874-5879 , 文章类型: Article,,卷期:2012年109-15]
- Obese fat pads are frequently undervascularized and hypoxic, leading to increased fibrosis, inflammation, and ultimately insulin resistance. We hypothesized that VEGF-A-induced stimulation of angiogenesis enables sustain...
- Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age
[作者:Yu, MC; Li, GJ; Lee, WW; Yuan, M; Cui, DP; Weyand, C; Goronzy, JJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E879-E888 , 文章类型: Article,,卷期:2012年109-15]
- T cell-dependent B-cell responses decline with age, suggesting defective CD4 T-cell function. CD4 memory T cells from individuals older than 65 y displayed increased and sustained transcription of the dual-specific phosp...
- Simple models of human brain functional networks
[作者:Vertes, PE; Alexander-Bloch, AF; Gogtay, N; Giedd, JN; Rapoport, JL; Bullmore, ET,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5868-5873 , 文章类型: Article,,卷期:2012年109-15]
- Human brain functional networks are embedded in anatomical space and have topological properties-small-worldness, modularity, fat-tailed degree distributions-that are comparable to many other complex networks. Although a...
- Disclosing the in vivo organization of a viral histone-like protein in Bacillus subtilis mediated by its capacity to recognize the viral genome
[作者:Holguera, I; Ballesteros-Plaza, D; Munoz-Espin, D; Salas, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5723-5728 , 文章类型: Article,,卷期:2012年109-15]
- Organization of replicating prokaryotic genomes requires architectural elements that, similarly to eukaryotic systems, induce topological changes such as DNA supercoiling. Bacteriophage phi 29 protein p6 has been describ...
- Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter
[作者:Chua, JJE; Butkevich, E; Worseck, JM; Kittelmann, M; Gronborg, M; Behrmann, E; Stelzl, U; Pavlos, NJ; Lalowski, MM; Eimer, S; Wanker, EE; Klopfenstein, DR; Jahn, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5862-5867 , 文章类型: Article,,卷期:2012年109-15]
- Presynaptic nerve terminals are formed from preassembled vesicles that are delivered to the prospective synapse by kinesin-mediated axonal transport. However, precisely how the various cargoes are linked to the motor pro...
- Trading-off fish biodiversity, food security, and hydropower in the Mekong River Basin
[作者:Ziv, G; Baran, E; Nam, S; Rodriguez-Iturbe, I; Levin, SA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5609-5614 , 文章类型: Article,,卷期:2012年109-15]
- The Mekong River Basin, site of the biggest inland fishery in the world, is undergoing massive hydropower development. Planned dams will block critical fish migration routes between the river's downstream floodplains and...
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