- Crystal Structure of p44, a Constitutively Active Splice Variant of Visual Arrestin
[作者:Granzin, J; Cousin, A; Weirauch, M; Schlesinger, R; Buldt, G; Batra-Safferling, R,期刊:Journal of Molecular Biology, 页码:611-618 , 文章类型: Article,,卷期:2012年416-5]
- Visual arrestin specifically binds to photoactivated and phosphorylated rhodopsin and inactivates phototransduction. In contrast, the p44 splice variant can terminate phototransduction by binding to nonphosphorylated lig...
- Crystal Structure of the Urokinase Receptor in a Ligand-Free Form
[作者:Xu, X; Gardsvoll, H; Yuan, C; Lin, L; Ploug, M; Huang, MD,期刊:Journal of Molecular Biology, 页码:629-641 , 文章类型: Article,,卷期:2012年416-5]
- The urokinase receptor urokinase-type plasminogen activator receptor (uPAR) is a surface receptor capable of not only focalizing urokinase-type plasminogen activator (uPA)-mediated fibrinolysis to the pericellular micro-...
- A Cyclic Peptide Inhibitor of ApoC-II Peptide Fibril Formation: Mechanistic Insight from NMR and Molecular Dynamics Analysis
[作者:Griffin, MDW; Yeung, L; Hung, A; Todorova, N; Mok, YF; Karas, JA; Gooley, PR; Yarovsky, I; Howlett, GJ,期刊:Journal of Molecular Biology, 页码:642-655 , 文章类型: Article,,卷期:2012年416-5]
- The misfolding and aggregation of proteins to form amyloid fibrils is a characteristic feature of several common age-related diseases. Agents that directly inhibit formation of amyloid fibrils represent one approach to c...
- Non-Stressful Death of 23S rRNA Mutant G2061C Defective in Puromycin Reaction
[作者:Sergiev, PV; Lesnyak, DV; Burakovsky, DE; Svetlov, M; Kolb, VA; Serebryakova, MV; Demina, IA; Govorun, VM; Dontsova, OA; Bogdanov, AA,期刊:Journal of Molecular Biology, 页码:656-667 , 文章类型: Article,,卷期:2012年416-5]
- Catalysis of peptide bond formation in the peptidyl transferase center is a major enzymatic activity of the ribosome. Mutations limiting peptidyl transferase activity are mostly lethal. However, cellular processes trigge...
- Structural, Bioinformatic, and In Vivo Analyses of Two Treponema pallidum Lipoproteins Reveal a Unique TRAP Transporter
[作者:Deka, RK; Brautigam, CA; Goldberg, M; Schuck, P; Tomchick, DR; Norgard, MV,期刊:Journal of Molecular Biology, 页码:678-696 , 文章类型: Article,,卷期:2012年416-5]
- Treponema pallidum, the bacterial agent of syphilis, is predicted to encode one tripartite ATP-independent periplasmic transporter (TRAP-T). TRAP-Ts typically employ a periplasmic substrate-binding protein (SBP) to deliv...
- Structural Basis of Substrate Binding Specificity Revealed by the Crystal Structures of Polyamine Receptors SpuD and SpuE from Pseudomonas aeruginosa
[作者:Wu, DH; Lim, SC; Dong, YH; Wu, J; Tao, F; Zhou, L; Zhang, LH; Song, HW,期刊:Journal of Molecular Biology, 页码:697-712 , 文章类型: Article,,卷期:2012年416-5]
- The type III secretion system (T3SS) of Pseudomonas aeruginosa is a key virulence determinant whose expression is induced by polyamine signals from mammalian host. SpuD and SpuE were postulated to be spermidine-preferent...
- Antifreeze Protein from Freeze-Tolerant Grass Has a Beta-Roll Fold with an Irregularly Structured Ice-Binding Site
[作者:Middleton, AJ; Marshall, CB; Faucher, F; Bar-Dolev, M; Braslavsky, I; Campbell, RL; Walker, VK; Davies, PL,期刊:Journal of Molecular Biology, 页码:713-724 , 文章类型: Article,,卷期:2012年416-5]
- The grass Lolium perenne produces an ice-binding protein (LpIBP) that helps this perennial tolerate freezing by inhibiting the recrystallization of ice. Ice-binding proteins (IBPs) are also produced by freeze-avoiding or...
- Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily (vol 415, pg 741, 2012)
[作者:Gajewski, S; Comeaux, EQ; Jafari, N; Bharatham, N; Bashford, D; White, SW; van Waardenburg, RCAM,期刊:Journal of Molecular Biology, 页码:725-725 , 文章类型: Correction,,卷期:2012年416-5]
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