- Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases
[作者:Yang, K; Trepanier, C; Sidhu, B; Xie, YF; Li, HB; Lei, G; Salter, MW; Orser, BA; Nakazawa, T; Yamamoto, T; Jackson, MF; MacDonald, JF,期刊:EMBO journal, 页码:805-816 , 文章类型: Article,,卷期:2012年31-4]
- Metaplasticity is a higher form of synaptic plasticity that is essential for learning and memory, but its molecular mechanisms remain poorly understood. Here, we report that metaplasticity of transmission at CA1 synapses...
- CSP alpha knockout causes neurodegeneration by impairing SNAP-25 function
[作者:Sharma, M; Burre, J; Bronk, P; Zhang, YS; Xu, W; Sudhof, TC,期刊:EMBO journal, 页码:829-841 , 文章类型: Article,,卷期:2012年31-4]
- At a synapse, the synaptic vesicle protein cysteine-string protein-alpha (CSP alpha) functions as a co-chaperone for the SNARE protein SNAP-25. Knockout (KO) of CSP alpha causes fulminant neurodegeneration that is rescue...
- Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels
[作者:Naito, H; Kidoya, H; Sakimoto, S; Wakabayashi, T; Takakura, N,期刊:EMBO journal, 页码:842-855 , 文章类型: Article,,卷期:2012年31-4]
- Vasculogenesis, the in-situ assembly of angioblast or endothelial progenitor cells (EPCs), may persist into adult life, contributing to new blood vessel formation. However, EPCs are scattered throughout newly developed b...
- Mechanoinduction of lymph vessel expansion
[作者:Planas-Paz, L; Strilic, B; Goedecke, A; Breier, G; Fassler, R; Lammert, E,期刊:EMBO journal, 页码:788-804 , 文章类型: Article,,卷期:2012年31-4]
- In the mammalian embryo, few mechanical signals have been identified to influence organ development and function. Here, we report that an increase in the volume of interstitial or extracellular fluid mechanically induces...
- Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner
[作者:Rybicka, JM; Balce, DR; Chaudhuri, S; Allan, ERO; Yates, RM,期刊:EMBO journal, 页码:932-944 , 文章类型: Article,,卷期:2012年31-4]
- The level of proteolysis within phagosomes of dendritic cells (DCs) is thought to be tightly regulated, as it directly impacts the cell's efficiency to process antigen. Activity of the antimicrobial effector NADPH oxidas...
- VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity
[作者:Kassmeier, MD; Mondal, K; Palmer, VL; Raval, P; Kumar, S; Perry, GA; Anderson, DK; Ciborowski, P; Jackson, S; Xiong, Y; Swanson, PC,期刊:EMBO journal, 页码:945-958 , 文章类型: Article,,卷期:2012年31-4]
- The N-terminus of full-length RAG1, though dispensable for RAG1/2 cleavage activity, is required for efficient V( D) J recombination. This region supports RING E3 ubiquitin ligase activity in vitro, but whether full-leng...
- A novel GRK2/HDAC6 interaction modulates cell spreading and motility
[作者:Lafarga, V; Aymerich, I; Tapia, O; Mayor, F; Penela, P,期刊:EMBO journal, 页码:856-869 , 文章类型: Article,,卷期:2012年31-4]
- Cell motility and adhesion involves dynamic microtubule (MT) acetylation/deacetylation, a process regulated by enzymes as HDAC6, a major cytoplasmic alpha-tubulin deacetylase. We identify G protein-coupled receptor kinas...
- dNTP pools determine fork progression and origin usage under replication stress
[作者:Poli, J; Tsaponina, O; Crabbe, L; Keszthelyi, A; Pantesco, V; Chabes, A; Lengronne, A; Pasero, P,期刊:EMBO journal, 页码:883-894 , 文章类型: Article,,卷期:2012年31-4]
- Intracellular deoxyribonucleoside triphosphate (dNTP) pools must be tightly regulated to preserve genome integrity. Indeed, alterations in dNTP pools are associated with increased mutagenesis, genomic instability and tum...
- Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype
[作者:Davidson, MB; Katou, Y; Keszthelyi, A; Sing, TL; Xia, T; Ou, JW; Vaisica, JA; Thevakumaran, N; Marjavaara, L; Myers, CL; Chabes, A; Shirahige, K; Brown, GW,期刊:EMBO journal, 页码:895-907 , 文章类型: Article,,卷期:2012年31-4]
- The integrity of the genome depends on diverse pathways that regulate DNA metabolism. Defects in these pathways result in genome instability, a hallmark of cancer. Deletion of ELG1 in budding yeast, when combined with hy...
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