- Synthesis and Structure-Activity Relationship (SAR) of (5,7-Disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as Potent Serotonin 5-HT(6) Receptor (5-HT(6)R) Antagonists
[作者:IVACHTCHENKO ALEXANDRE V; GOLOVINA ELENA S; KADIEVA MADINA G; KYSIL VOLODYMYR M; MITKIN OLEG D; TKACHENKO SERGEY E; OKUN ILYA M,期刊:Journal of Medicinal Chemistry, 页码:8161-8173 , 文章类型: Article,,卷期:2011年54-23]
- Syntheses, biological evaluation as 5-HT(6) receptor (5-HT(6)R) antagonists, and structure activity relationships for a series of novel 5,7-disubstituted (3-arylsulfonyl-pyrazolo[1,5-a]pyrimidins are disclosed. The molec...
- Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13
[作者:TAYLOR STEVEN J; ABEYWARDANE ASITHA; LIANG SHUANG; MUEGGE INGO; PADYANA ANIL K; XIONG ZHAOMING; HILLDRZEWI MELISSA; FARMER BENNETT; LI XIANG; COLLINS BRANDON; LI JOHN XIANG; HEIMRIETHER ALEXANDER; PROUDFOOT JOHN; ZHANG QIANG; GOLDBERG DANIEL; ZUVELAJELASKA LJILJANA; ZAHER HANI; LI JUN; FARROW NEIL A,期刊:Journal of Medicinal Chemistry, 页码:8174-8187 , 文章类型: Article,,卷期:2011年54-23]
- Matrix metalloproteases (MMPs) play an important role in cartilage homeostasis under both normal and inflamed disease states and, thus, have become attractive targets for the treatment of arthritic diseases. Herein, we d...
- Investigating the Antimalarial Action of 1,2,4-Trioxolanes with Fluorescent Chemical Probes
[作者:HARTWIG CARMONY L; LAUTERWASSER ERICA M W; MAHAJAN SUMIT S; HOKE JONATHAN M; COOPER ROLAND A; RENSLO ADAM R,期刊:Journal of Medicinal Chemistry, 页码:8207-8213 , 文章类型: Article,,卷期:2011年54-23]
- The 1,2,4-trioxolanes are a new class of synthetic peroxidic antimalarials currently in human clinical trials. The well-known reactivity of the 1,2,4-trioxolane ring toward inorganic ferrous iron and ferrous iron heme is...
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