- Archaeal Translation Initiation Factor aIF2 Can Substitute for Eukaryotic eIF2 in Ribosomal Scanning during Mammalian 48S Complex Formation
[作者:Dmitriev, SE; Stolboushkina, EA; Terenin, IM; Andreev, DE; Garber, MB; Shatsky, IN,期刊:Journal of Molecular Biology, 页码:106-114 , 文章类型: Article,,卷期:2011年413-1]
- Heterotrimeric translation initiation factor (IF) a/eIF2 (archaeal/eukaryotic IF 2) is present in both Eukarya and Archaea. Despite strong structural similarity between a/eIF2 orthologs from the two domains of life, thei...
- Spectroscopy and a High-Resolution Crystal Structure of Tyr263 Mutants of Cyanobacterial Phytochrome Cph1
[作者:Mailliet, J; Psakis, G; Feilke, K; Sineshchekov, V; Essen, LO; Hughes, J,期刊:Journal of Molecular Biology, 页码:115-127 , 文章类型: Article,,卷期:2011年413-1]
- Phytochromes are biliprotein photoreceptors that can be photoswitched between red-light-absorbing state (Pr) and far-red-light-absorbing state (Pfr). Although three-dimensional structures of both states have been reporte...
- Light-Induced Conformational Changes in Full-Length Arabidopsis thaliana Cryptochrome
[作者:Kondoh, M; Shiraishi, C; Muller, P; Ahmad, M; Hitomi, K; Getzoff, ED; Terazima, M,期刊:Journal of Molecular Biology, 页码:128-137 , 文章类型: Article,,卷期:2011年413-1]
- Cryptochromes (CRYs) are widespread flavoproteins with homology to photolyases (PHRs), a class of blue-light-activated DNA repair enzymes. Unlike PHRs, both plant and animal CRYs have a C-terminal domain. This cryptochro...
- Structure of the Food-Poisoning Clostridium perfringens Enterotoxin Reveals Similarity to the Aerolysin-Like Pore-Forming Toxins
[作者:Briggs, DC; Naylor, CE; Smedley, JG; Lukoyanova, N; Robertson, S; Moss, DS; McClane, BA; Basak, AK,期刊:Journal of Molecular Biology, 页码:138-149 , 文章类型: Article,,卷期:2011年413-1]
- Clostridium perfringens enterotoxin (CPE) is a major cause of food poisoning and antibiotic-associated diarrhea. Upon its release from C. perfringens spores, CPE binds to its receptor, claudin, at the tight junctions bet...
- Improving the Resistance of a Eukaryotic beta-Barrel Protein to Thermal and Chemical Perturbations
[作者:Gessmann, D; Mager, F; Naveed, H; Arnold, T; Weirich, S; Linke, D; Liang, J; Nussberger, S,期刊:Journal of Molecular Biology, 页码:150-161 , 文章类型: Article,,卷期:2011年413-1]
- beta-Barrel membrane proteins have regular structures with extensive hydrogen-bond networks between their transmembrane (TM) beta-strands, which stabilize their protein fold. Nevertheless, weakly stable TM regions, which...
- Crystal Structures of an O-Like Blue Form and an Anion-Free Yellow Form of pharaonis Halorhodopsin
[作者:Kanada, S; Takeguchi, Y; Murakami, M; Ihara, K; Kouyama, T,期刊:Journal of Molecular Biology, 页码:162-176 , 文章类型: Article,,卷期:2011年413-1]
- Halorhodopsin from Natronomonas pharaonis (pHR) was previously crystallized into a monoclinic space group C2, arid the structure of the chloride-bound purple form was determined. Here, we report the crystal structures of...
- Characterization of a Myosin VII MyTH/FERM Domain
[作者:Moen, RJ; Johnsrud, DO; Thomas, DD; Titus, MA,期刊:Journal of Molecular Biology, 页码:17-23 , 文章类型: Article,,卷期:2011年413-1]
- A group of closely related myosins is characterized by the presence of at least one MyTH/FERM (myosin tail homology; band 4.1, ezrin, radixin, moesin) domain in their C-terminal tails. This domain interacts with a variet...
- Structural Characterization and Membrane Localization of ExsB from the Type III Secretion System (T3SS) of Pseudomonas aeruginosa
[作者:Izore, T; Perdu, C; Job, V; Attree, I; Faudry, E; Dessen, A,期刊:Journal of Molecular Biology, 页码:236-246 , 文章类型: Article,,卷期:2011年413-1]
- Pseudomonas aeruginosa is an opportunistic human pathogen that employs a finely tuned type III secretion system (T3SS) to inject toxins directly into the cytoplasm of target cells. ExsB is a 15.6-kDa protein encoded in a...
- Structure and Substrate Recognition of the Staphylococcus aureus Protein Tyrosine Phosphatase PtpA
[作者:Vega, C; Chou, S; Engel, K; Harrell, ME; Rajagopal, L; Grundner, C,期刊:Journal of Molecular Biology, 页码:24-31 , 文章类型: Article,,卷期:2011年413-1]
- Phosphosignaling through pSer/pThr/pTyr is emerging as a common signaling mechanism in prokaryotes. The human pathogen Staphylococcus aureus produces two low-molecular-weight protein tyrosine phosphatases (PTPs), PtpA an...
- HuCAL PLATINUM, a Synthetic Fab Library Optimized for Sequence Diversity and Superior Performance in Mammalian Expression Systems
[作者:Prassler, J; Thiel, S; Pracht, C; Polzer, A; Peters, S; Bauer, M; Norenberg, S; Stark, Y; Kolln, J; Popp, A; Urlinger, S; Enzelberger, M,期刊:Journal of Molecular Biology, 页码:261-278 , 文章类型: Article,,卷期:2011年413-1]
- This article describes the design of HuCAL (human combinatorial antibody library) PLATINUM, an optimized, second-generation, synthetic human Fab antibody library with six trinucleotide-randomized complementarity-determin...
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