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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Mutations and Natural Selection in the Protein World [作者：Chernoff, YO,期刊：Journal of Molecular Biology, 页码：525-526 , 文章类型： Editorial Material，,卷期：2011年413-3] Conformational Transformation and Selection of Synthetic Prion Strains [作者：Ghaemmaghami, S; Watts, JC; Nguyen, HO; Hayashi, S; DeArmond, SJ; Prusiner, SB,期刊：Journal of Molecular Biology, 页码：527-542 , 文章类型： Article，,卷期：2011年413-3] Prion protein is capable of folding into multiple self-replicating prion strains that produce phenotypically distinct neurological disorders. Although prion strains often breed true upon passage, they can also transform ... On Unsatisfied Hydrogen Bonds in the N-Terminal Subdomain of Villin Headpiece [作者：Brown, JW; Farelli, JD; McKnight, CJ,期刊：Journal of Molecular Biology, 页码：543-547 , 文章类型： Article，,卷期：2011年413-3] Villin headpiece is a small autonomously folding protein that has emerged as a model system for understanding the fundamental tenets governing protein folding. In this communication, we employ NMR and X-ray crystallograp... Interaction with the Nascent RNA Is a Prerequisite for the Recruitment of Rho to the Transcription Elongation Complex In Vitro [作者：Kalyani, BS; Muteeb, G; Qayyum, MZ; Sen, R,期刊：Journal of Molecular Biology, 页码：548-560 , 文章类型： Article，,卷期：2011年413-3] In the conventional model of the Rho-dependent transcription termination, the terminator Rho binds to the rut (Rho utilization) site and translocates along the nascent RNA prior to making possible interactions with the e... Structure of an Enclosed Dimer Formed by the Drosophila Period Protein [作者：King, HA; Hoelz, A; Crane, BR; Young, MW,期刊：Journal of Molecular Biology, 页码：561-572 , 文章类型： Article，,卷期：2011年413-3] Period (PER) is the major transcription inhibitor in metazoan circadian clocks and lies at the center of several feedback loops that regulate gene expression. Dimerization of Drosophila PER influences nuclear translocati... The Mechanical Role of VASP in an Arp2/3-Complex-Based Motility Assay [作者：Suei, S; Seyan, R; Noguera, P; Manzi, J; Plastino, J; Kreplak, L,期刊：Journal of Molecular Biology, 页码：573-583 , 文章类型： Article，,卷期：2011年413-3] The comet motility assay, inspired by Listeria locomotion, has been used extensively as an in vitro model to study the structural and motile properties of the actin cytoskeleton. However, there are no quantitative measur... Actin Filament Dynamics in the Actomyosin VI Complex Is Regulated Allosterically by Calcium-Calmodulin Light Chain [作者：Prochniewicz, E; Pierre, A; McCullough, BR; Chin, HF; Cao, WX; Saunders, LP; Thomas, DD; De La Cruz, EM,期刊：Journal of Molecular Biology, 页码：584-592 , 文章类型： Article，,卷期：2011年413-3] The contractile and enzymatic activities of myosin VI are regulated by calcium binding to associated calmodulin (CaM) light chains. We have used transient phosphorescence anisotropy to monitor the microsecond rotational ... Cell-Free Expression and Assembly of ATP Synthase [作者：Matthies, D; Haberstock, S; Joos, F; Dotsch, V; Vonck, J; Bernhard, F; Meier, T,期刊：Journal of Molecular Biology, 页码：593-603 , 文章类型： Article，,卷期：2011年413-3] Cell-free (CF) expression technologies have emerged as promising methods for the production of individual membrane proteins of different types and origin. However, many membrane proteins need to be integrated in complex ... Helix VIII of NhaA Na (+)/H (+) Antiporter Participates in the Periplasmic Cation Passage and pH Regulation of the Antiporter [作者：Diab, M; Rimon, A; Tzubery, T; Padan, E,期刊：Journal of Molecular Biology, 页码：604-614 , 文章类型： Article，,卷期：2011年413-3] The crystal structure of Escherichia coli NhaA determined at pH 4 has provided insights into the mechanism of activity of a pH-regulated Na (+)/Fr (+) antiporter. However, because NhaA is active at physiological pH (pH 6... Crystallographic Analysis of the Primary Photochemical Reaction of Squid Rhodopsin [作者：Murakami, M; Kouyama, T,期刊：Journal of Molecular Biology, 页码：615-627 , 文章类型： Article，,卷期：2011年413-3] Visual signal transduction is initiated by the photoisomerization of 11-cis retinal upon rhodopsin ligation. Unlike vertebrate rhodopsin, which interacts with Gt-type G-protein to stimulate the cyclic GMP signaling pathw... Engineering an Ultra-Thermostable beta(1)-Adrenoceptor [作者：Miller, JL; Tate, CG,期刊：Journal of Molecular Biology, 页码：628-638 , 文章类型： Article，,卷期：2011年413-3] Conformational thermostabilisation of G-protein-coupled receptors is a successful strategy for their structure determination. The thermostable mutants tolerate short-chain detergents, such as octylglucoside and nonylgluc... Structural Characterization of Intramolecular Hg (2+) Transfer between Flexibly Linked Domains of Mercuric Ion Reductase [作者：Johs, A; Harwood, IM; Parks, JM; Nauss, RE; Smith, JC; Liang, LY; Miller, SM,期刊：Journal of Molecular Biology, 页码：639-656 , 文章类型： Article，,卷期：2011年413-3] The enzyme mercuric ion reductase MerA is the central component of bacterial mercury resistance encoded by the mer operon. Many MerA proteins possess metallochaperone-like N-terminal domains (NmerA) that can transfer Hg(... Conserved Glycine Residues in the P-Loop of ATP Synthases Form a Doorframe for Nucleotide Entrance [作者：Priya, R; Kumar, A; Manimekalai, MSS; Gruber, G,期刊：Journal of Molecular Biology, 页码：657-666 , 文章类型： Article，,卷期：2011年413-3] The phosphate binding loop (GXXXXGKT(S)) is conserved in several mononucleotide-binding proteins with similar three-dimensional structures. Although variations in other amino acids have been noted, the first glycine and ... Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors [作者：Unno, M; Shinohara, M; Takayama, K; Tanaka, H; Teruya, K; Doh-ura, K; Sakai, R; Sasaki, M; Ikeda-Saito, M,期刊：Journal of Molecular Biology, 页码：667-683 , 文章类型： Article，,卷期：2011年413-3] Dysiherbaine (DH) and neodysiherbaine A (NDH) selectively bind and activate two kainate-type ionotropic glutamate receptors, GluK1 and GluK2. The ligand-binding domains of human GluK1 and GluK2 were crystallized as bound... Iron-Coordinating Tyrosine Is a Key Determinant of NEAT Domain Heme Transfer [作者：Grigg, JC; Mao, CX; Murphy, MEP,期刊：Journal of Molecular Biology, 页码：684-698 , 文章类型： Article，,卷期：2011年413-3] In humans, heme iron is the most abundant iron source, and bacterial pathogens such as Staphylococcus aureus acquire it for growth. IsdB of S. aureus acquires Fe(III)-protoporphyrin IX (heme) from hemoglobin for transfer... Crystal Structure of Cardiac Troponin C Regulatory Domain in Complex with Cadmium and Deoxycholic Acid Reveals Novel Conformation [作者：Li, AY; Lee, J; Borek, D; Otvvinowski, Z; Tibbits, GF; Paetzel, M,期刊：Journal of Molecular Biology, 页码：699-711 , 文章类型： Article，,卷期：2011年413-3] The amino-terminal regulatory domain of cardiac troponin C (cNTnC) plays an important role as the calcium sensor for the troponin complex. Calcium binding to cNTnC results in conformational changes that trigger a cascade...