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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Systematic Chromosomal Deletion of Bacterial Ribosomal Protein Genes [作者：Shoji, S; Dambacher, CM; Shajani, Z; Williamson, JR; Schultz, PG,期刊：Journal of Molecular Biology, 页码：751-761 , 文章类型： Article，,卷期：2011年413-4] Detailed studies of ribosomal proteins (RPs), essential components of the protein biosynthetic machinery, have been hampered by the lack of readily accessible chromosomal deletions of the corresponding genes. Here, we re... Molecular Basis for Herpesvirus Entry Mediator Recognition by the Human Immune Inhibitory Receptor CD160 and Its Relationship to the Cosignaling Molecules BTLA and LIGHT [作者：Kojima, R; Kajikawa, M; Shiroishi, M; Kuroki, K; Maenaka, K,期刊：Journal of Molecular Biology, 页码：762-772 , 文章类型： Article，,卷期：2011年413-4] CD160 was recently identified as a T cell coinhibitory molecule that interacts with the herpesvirus entry mediator (HVEM) on antigen-presenting cells to deliver a potent inhibitory signal to CD4(+) T cells. HVEM also bin... Analysis of Binding Site Hot Spots on the Surface of Ras GTPase [作者：Buhrman, G; O'Connor, C; Zerbe, B; Kearney, BM; Napoleon, R; Kovrigina, EA; Vajda, S; Kozakov, D; Kovrigin, EL; Mattos, C,期刊：Journal of Molecular Biology, 页码：773-789 , 文章类型： Article，,卷期：2011年413-4] We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers. Upon activation of the allosteric switch, there is a... Composition and Topology of the Endoplasmic Reticulum-Mitochondria Encounter Structure [作者：Stroud, DA; Oeljeklaus, S; Wiese, S; Bohnert, M; Lewandrowski, U; Sickmann, A; Guiard, B; van der Laan, M; Warscheid, B; Wiedemann, N,期刊：Journal of Molecular Biology, 页码：743-750 , 文章类型： Article，,卷期：2011年413-4] Eukaryotic cells contain multiple organelles, which are functionally and structurally interconnected. The endoplasmic reticulum-mitochondria encounter structure (ERMES) forms a junction between mitochondria and the endop... The NLRP12 Pyrin Domain: Structure, Dynamics, and Functional Insights [作者：Pinheiro, AS; Eibl, C; Ekman-Vural, Z; Schwarzenbacher, R; Peti, W,期刊：Journal of Molecular Biology, 页码：790-803 , 文章类型： Article，,卷期：2011年413-4] The initial line of defense against infection is sustained by the innate immune system. Together, membrane-bound Toll-like receptors and cytosolic nucleotide-binding domain and leucine-rich repeat-containing receptors (N... Cyt1Aa Toxin: Crystal Structure Reveals Implications for Its Membrane-Perforating Function [作者：Cohen, S; Albeck, S; Ben-Dov, E; Cahan, R; Firer, M; Zaritsky, A; Dym, O,期刊：Journal of Molecular Biology, 页码：804-814 , 文章类型： Article，,卷期：2011年413-4] During sporulation, Bacillus thuringiensis subsp. israelensis produces a mosquito larvicidal protein complex containing several crystalline and cytolytic (Cyt) toxins. Here, the activated monomeric form of Cyt1Aa, the mo... Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family [作者：Ohto, U; Miyake, K; Shimizu, T,期刊：Journal of Molecular Biology, 页码：815-825 , 文章类型： Article，,卷期：2011年413-4] The Toll-like receptor (TLR) 4/MD-2 heterodimer senses lipopolysaccharide (LPS). RP105 (radioprotective 105 kDa), a TLR-related molecule, is similar to TLR4 in that the extracellular leucine-rich repeats associate with M... DARPins Recognizing the Tumor-Associated Antigen EpCAM Selected by Phage and Ribosome Display and Engineered for Multivalency [作者：Stefan, N; Martin-Killias, P; Wyss-Stoeckle, S; Honegger, A; Zangemeister-Wittke, U; Pluckthun, A,期刊：Journal of Molecular Biology, 页码：826-843 , 文章类型： Article，,卷期：2011年413-4] Designed Ankyrin Repeat Proteins (DARPins) represent a novel class of binding molecules. Their favorable biophysical properties such as high affinity, stability and expression yields make them ideal candidates for tumor ... The Structures of Thermoplasma volcanium Phosphoribosyl Pyrophosphate Synthetase Bound to Ribose-5-Phosphate and ATP Analogs [作者：Cherney, MM; Cherney, LT; Garen, CR; James, MNG,期刊：Journal of Molecular Biology, 页码：844-856 , 文章类型： Article，,卷期：2011年413-4] Phosphoribosyl pyrophosphate (PRPP) synthetase catalyzes the transfer of the pyrophosphate group from ATP to ribose-5-phosphate (R5P) yielding PRPP and AMP. PRPP is an essential metabolite that plays a central role in ce... Impairment of Ubiquitin-Proteasome System by E334K cMyBPC Modifies Channel Proteins, Leading to Electrophysiological Dysfunction [作者：Bahrudin, U; Morikawa, K; Takeuchi, A; Kurata, Y; Miake, J; Mizuta, E; Adachi, K; Higaki, K; Yamamoto, Y; Shirayoshi, Y; Yoshida, A; Kato, M; Yamamoto, K; Nanba, E; Morisaki, H; Morisaki, T; Matsuoka, S; Ninomiya, H; Hisatome, I,期刊：Journal of Molecular Biology, 页码：857-878 , 文章类型： Article，,卷期：2011年413-4] Cardiac arrhythmogenesis is regulated by channel proteins whose protein levels are in turn regulated by the ubiquitin-proteasome system (UPS). We have previously reported on UPS impairment induced by E334K cardiac myosin... The Rate of PolyQ-Mediated Aggregation Is Dramatically Affected by the Number and Location of Surrounding Domains [作者：Robertson, AL; Bate, MA; Buckle, AM; Bottomley, SP,期刊：Journal of Molecular Biology, 页码：879-887 , 文章类型： Article，,卷期：2011年413-4] The nine polyglutamine (polyQ) neurodegenerative diseases are caused in part by a gain-of-function mechanism involving protein misfolding, the deposition of beta-sheet-rich aggregates and neuronal toxicity. While previou... Structural Change in beta-Sheet A of Z alpha(1)-Antitrypsin Is Responsible for Accelerated Polymerization and Disease [作者：Knaupp, AS; Bottomley, SP,期刊：Journal of Molecular Biology, 页码：888-898 , 文章类型： Article，,卷期：2011年413-4] The presence of the Z mutation (Glu342Lys) is responsible for more than 95% of alpha(1)-antitrypsin (alpha(1)AT) deficiency cases. It leads to increased polymerization of the serpin alpha(1)AT during its synthesis and in... Estrogen Increases Expression of the Human Prostacyclin Receptor within the Vasculature through an ER alpha-Dependent Mechanism (vol 396, pg 473, 2010) [作者：Turner, EC; Kinsella, BT,期刊：Journal of Molecular Biology, 页码：899-899 , 文章类型： Correction，,卷期：2011年413-4]