- Molecular Mechanism of Transcription Inhibition by Phage T7 gp2 Protein
[作者:Mekler, V; Minakhin, L; Sheppard, C; Wigneshweraraj, S; Severinov, K,期刊:Journal of Molecular Biology, 页码:1016-1027 , 文章类型: Article,,卷期:2011年413-5]
- Escherichia coli T7 bacteriophage gp2 protein is a potent inhibitor of host RNA polymerase (RNAP). gp2 inhibits formation of open promoter complex by binding to the beta' jaw, an RNAP domain that interacts with downstrea...
- Tilt-Pair Analysis of Images from a Range of Different Specimens in Single-Particle Electron Cryomicroscopy
[作者:Henderson, R; Chen, SX; Chen, JZ; Grigorieff, N; Passmore, LA; Ciccarelli, L; Rubinstein, JL; Crowther, RA; Stewart, PL; Rosenthal, PB,期刊:Journal of Molecular Biology, 页码:1028-1046 , 文章类型: Article,,卷期:2011年413-5]
- The comparison of a pair of electron microscope images recorded at different specimen tilt angles provides a powerful approach for evaluating the quality of images, image-processing procedures, or three-dimensional struc...
- Hotspot-Centric De Novo Design of Protein Binders
[作者:Fleishman, SJ; Corn, JE; Strauch, EM; Whitehead, TA; Karanicolas, J; Baker, D,期刊:Journal of Molecular Biology, 页码:1047-1062 , 文章类型: Article,,卷期:2011年413-5]
- Protein protein interactions play critical roles in biology, and computational design of interactions could be useful in a range of applications. We describe in detail a general approach to de novo design of protein inte...
- Novel Structural Insights into Rotavirus Recognition of Ganglioside Glycan Receptors
[作者:Yu, X; Coulson, BS; Fleming, FE; Dyason, JC; von Itzstein, M; Blanchard, H,期刊:Journal of Molecular Biology, 页码:929-939 , 文章类型: Article,,卷期:2011年413-5]
- Rotaviruses ubiquitously infect children under the age of 5, being responsible for more than half a million diarrhoeal deaths each year worldwide. Host cell oligosaccharides containing sialic acid(s) are critical for att...
- Functional Characterization of Fdx1: Evidence for an Evolutionary Relationship between P450-Type and ISC-Type Ferredoxins
[作者:Ewen, KM; Hannemann, F; Lametti, S; Morleo, A; Bernhardt, R,期刊:Journal of Molecular Biology, 页码:940-951 , 文章类型: Article,,卷期:2011年413-5]
- Ferredoxins are ubiquitous proteins with electron transfer activity involved in a variety of biological processes. In this work, we investigated the characteristics and function of Fdx1 from Sorangium cellulosum So ce56 ...
- High-Throughput Genetic Identification of Functionally Important Regions of the Yeast DEAD-Box Protein Mss116p
[作者:Mohr, G; Del Campo, M; Turner, KG; Gilman, B; Wolf, RZ; Lambowitz, AM,期刊:Journal of Molecular Biology, 页码:952-972 , 文章类型: Article,,卷期:2011年413-5]
- The Saccharomyces cerevisiae DEAD-box protein Mss116p is a general RNA chaperone that functions in splicing mitochondrial group I and group II introns. Recent X-ray crystal structures of Mss116p in complex with ATP analo...
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