- S-Glutathionylation of Cysteine 99 in the APE1 Protein Impairs Abasic Endonuclease Activity
[作者:Kim, YJ; Kim, D; Illuzzi, JL; Delaplane, S; Su, D; Bernier, M; Gross, ML; Georgiadis, MM; Wilson, DM,期刊:Journal of Molecular Biology, 页码:313-326 , 文章类型: Article,,卷期:2011年414-3]
- Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is a central participant in the base excision repair pathway, exhibiting AP endonuclease activity that incises the DNA backbone 5' to an abasic site. Besides its pro...
- A Disulfide-Free Single-Domain V(L) lntrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition
[作者:Schiefner, A; Chatwell, L; Korner, J; Neumaier, L; Colby, DW; Volkmer, R; Wittrup, KD; Skerra, A,期刊:Journal of Molecular Biology, 页码:337-355 , 文章类型: Article,,卷期:2011年414-3]
- We present the crystal structure and biophysical characterization of a human V(L) [variable domain immunoglobulin (Ig) light chain] single-domain intrabody that binds to the huntingtin (Htt) protein and has been engineer...
- Structure of the Escherichia coil Phosphonate Binding Protein PhnD and Rationally Optimized Phosphonate Biosensors
[作者:Alicea, I; Marvin, JS; Miklos, AE; Ellington, AD; Looger, LL; Schreiter, ER,期刊:Journal of Molecular Biology, 页码:356-369 , 文章类型: Article,,卷期:2011年414-3]
- The phnD gene of Escherichia coli encodes the periplasmic binding protein of the phosphonate (Pn) uptake and utilization pathway. We have crystallized and determined structures of E. coli PhnD (EcPhnD) in the absence of ...
- Disparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding Mechanism
[作者:Scott, DR; Borbulevych, OY; Piepenbrink, KH; Corcelli, SA; Baker, BM,期刊:Journal of Molecular Biology, 页码:385-400 , 文章类型: Article,,卷期:2011年414-3]
- alpha beta T-cell receptors (TCRs) recognize multiple antigenic peptides bound and presented by major histocompatibility complex molecules. TCR crossreactivity has been attributed in part to the flexibility of TCR comple...
- The Crystal Structure of Odorant Binding Protein 7 from Anopheles gambiae Exhibits an Outstanding Adaptability of Its Binding Site
[作者:Lagarde, A; Spinelli, S; Tegoni, M; He, XL; Field, L; Zhou, JJ; Cambillau, C,期刊:Journal of Molecular Biology, 页码:401-412 , 文章类型: Article,,卷期:2011年414-3]
- Anopheles gambiae (Agam) targets human and animals by using its olfactory system, leading to the spread of Plasmodium falciparum, the malaria vector. Odorant binding proteins (OBPs) participate to the first event in odor...
- Mutations in the Gene Encoding C8orf38 Block Complex I Assembly by Inhibiting Production of the Mitochondria-Encoded Subunit ND1
[作者:McKenzie, M; Tucker, EJ; Compton, AG; Lazarou, M; George, C; Thorburn, DR; Ryan, MT,期刊:Journal of Molecular Biology, 页码:413-426 , 文章类型: Article,,卷期:2011年414-3]
- The assembly of complex I (NADH ubiquinone oxidoreductase) is a complicated process, requiring the integration of 45 subunits encoded by both nuclear and mitochondrial DNAs into a structure of approximately 1 MDa. A numb...
- Oxidative Folding and Structural Analyses of a Kunitz-Related Inhibitor and Its Disulfide Intermediates: Functional Implications
[作者:Bronsoms, S; Pantoja-Uceda, D; Gabrijelcic-Geiger, D; Sanglas, L; Aviles, FX; Santoro, J; Sommerhoff, CP; Arolas, JL,期刊:Journal of Molecular Biology, 页码:427-441 , 文章类型: Article,,卷期:2011年414-3]
- Tick-derived protease inhibitor (TdPI) is a tight-binding Kunitz-related inhibitor of human tryptase beta with a unique structure and disulfide-bond pattern. Here we analyzed its oxidative folding and reductive unfolding...
- Molecular Links between the E2 Envelope Glycoprotein and Nucleocapsid Core in Sindbis Virus
[作者:Tang, JH; Jose, J; Chipman, P; Zhang, W; Kuhn, RJ; Baker, TS,期刊:Journal of Molecular Biology, 页码:442-459 , 文章类型: Article,,卷期:2011年414-3]
- A three-dimensional reconstruction of Sindbis virus at 7.0 angstrom resolution presented here provides a detailed view of the virion structure and includes structural evidence for key interactions that occur between the ...
- Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope
[作者:Stanfield, RL; Julien, JP; Pejchal, R; Gach, JS; Zwick, MB; Wilson, IA,期刊:Journal of Molecular Biology, 页码:460-476 , 文章类型: Article,,卷期:2011年414-3]
- Antibody Z13e1 is a relatively broadly neutralizing anti-human immunodeficiency virus type 1 antibody that recognizes the membrane-proximal external region (MPER) of the human immunodeficiency virus type 1 envelope glyco...
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