- Crosstalk between Raf/MEK/ERK and PI3K/AKT in Suppression of Bax Conformational Change by Grp75 under Glucose Deprivation Conditions
[作者:Yang, L; Guo, WW; Zhang, QL; Li, HY; Liu, XY; Yang, YL; Zuo, J; Liu, W,期刊:Journal of Molecular Biology, 页码:654-666 , 文章类型: Article,,卷期:2011年414-5]
- During glucose deprivation (GD)-induced cellular stress, the molecular chaperone glucose-regulated protein 75 (Grp75)/Mortalin/PBP74/mtHSP70 (hereafter termed "Grp75") plays an important role in the suppression of apopto...
- The Role of Tropomyosin Domains in Cooperative Activation of the Actin-Myosin Interaction
[作者:Oguchi, Y; Ishizuka, J; Hitchcock-DeGregori, SE; Ishiwata, S; Kawai, M,期刊:Journal of Molecular Biology, 页码:667-680 , 文章类型: Article,,卷期:2011年414-5]
- To establish et-tropomyosin (Tm)'s structure function relationships in cooperative regulation of muscle contraction, thin filaments were reconstituted with a variety of Tm mutants (Delta 2Tm, Delta 3Tm, Delta 6Tm, P2sTm,...
- Structural Model for p75(NTR)-TrkA Intracellular Domain Interaction: A Combined FRET and Bioinformatics Study
[作者:Lacaruso, MF; Galli, S; Marti, M; Villalta, JI; Estrin, DA; Jares-Erijman, EA; Pietrasanta, LI,期刊:Journal of Molecular Biology, 页码:681-698 , 文章类型: Article,,卷期:2011年414-5]
- Nerve growth factor (NGF) is a member of the neurotrophins, which are important regulators of embryonic development and adult function in the vertebrate nervous systems. The signaling elicited by NGF regulates diverse ac...
- Neuroprotective and Nootropic Drug Noopept Rescues alpha-Synuclein Amyloid Cytotoxicity
[作者:Jia, XE; Gharibyani, AL; Ohman, A; Liu, YG; Olofsson, A; Morozova-Roche, LA,期刊:Journal of Molecular Biology, 页码:699-712 , 文章类型: Article,,卷期:2011年414-5]
- Parkinson's disease is a common neurodegenerative disorder characterized by alpha-synuclein (alpha-Syn)-containing Lewy body formation and selective loss of dopaminergic neurons in the substantia nigra. We have demonstra...
- Crystal Structure of the Ligand Binding Domain of Netrin G2
[作者:Brasch, J; Harrison, OJ; Ahlsen, G; Liu, Q; Shapiro, L,期刊:Journal of Molecular Biology, 页码:723-734 , 文章类型: Article,,卷期:2011年414-5]
- Netrin G proteins represent a small family of synaptic cell adhesion molecules related to netrins and to the polymerization domains of laminins. Two netrin G proteins are encoded in vertebrate genomes, netrins G1 and G2,...
- Human Cardiac Myosin Binding Protein C: Structural Flexibility within an Extended Modular Architecture
[作者:Jeffries, CM; Lu, YL; Hynson, RMG; Taylor, JE; Ballesteros, M; Kwan, AH; Trewhella, J,期刊:Journal of Molecular Biology, 页码:735-748 , 文章类型: Article,,卷期:2011年414-5]
- New insights into the modular organization and flexibility of the N-terminal half of human cardiac myosin binding protein C (cMyBP-C) and information on the association state of the full-length protein have been deduced ...
- Influence of Histone Tails and H4 Tail Acetylations on Nucleosome-Nucleosome Interactions
[作者:Liu, Y; Lu, CN; Yang, Y; Fan, YP; Yang, RL; Liu, CF; Korolev, NL; Nordenskiold, L,期刊:Journal of Molecular Biology, 页码:749-764 , 文章类型: Article,,卷期:2011年414-5]
- Nucleosome nucleosome interaction plays a fundamental role in chromatin folding and self-association. The cation-induced condensation of nucleosome core particles (NCPs) displays properties similar to those of chromatin ...
- A Three-Dimensional FRET Analysis to Construct an Atomic Model of the Actin-Tropomyosin Complex on a Reconstituted Thin Filament
[作者:Miki, M; Makimura, S; Saitoh, T; Bunya, M; Sugahara, Y; Ueno, Y; Kimura-Sakiyama, C; Tobita, H,期刊:Journal of Molecular Biology, 页码:765-782 , 文章类型: Article,,卷期:2011年414-5]
- Fluorescence resonance energy transfer (FRET) was used to construct an atomic model of the actin tropomyosin (Tm) complex on a reconstituted thin filament. We generated five single-cysteine mutants in the 146-174 region ...
- Oligomerization Propensity and Flexibility of Yeast Frataxin Studied by X-ray Crystallography and Small-Angle X-ray Scattering
[作者:Soderberg, CAG; Shkumatov, AV; Rajan, S; Gakh, O; Svergun, DI; Isaya, G; Al-Karadaghi, S,期刊:Journal of Molecular Biology, 页码:783-797 , 文章类型: Article,,卷期:2011年414-5]
- Frataxin is a mitochondrial protein with a central role in iron homeostasis. Defects in frataxin function lead to Friedreich's ataxia, a progressive neurodegenerative disease with childhood onset. The function of frataxi...
- Structural and Mechanistic Characterization of Leukocyte-Type Core 2 beta 1,6-N-Acetylglucosaminyltransferase: A Metal-Ion-Independent GT-A Glycosyltransferase
[作者:Pak, JE; Satkunarajah, M; Seetharaman, J; Rini, JM,期刊:Journal of Molecular Biology, 页码:798-811 , 文章类型: Article,,卷期:2011年414-5]
- Leukocyte-type core 2 beta 1,6-N-acetylglucosaminyltransferase (C2GnT-L) is an inverting, metal-ion-independent glycosyltransferase that catalyzes the formation of mucin-type core 2 O-glycans. C2GnT-L belongs to the GT-A...
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