- Cell Membranes: The Lipid Perspective
[作者:Coskun, U; Simons, K,期刊:Structure, 页码:1543-1548 , 文章类型: Review,,卷期:2011年19-11]
- Although cell membranes are packed with proteins mingling with lipids, remarkably little is known about how proteins interact with lipids to carry out their function. Novel analytical tools are revealing the astounding d...
- Molecular Simulation Approaches to Membrane Proteins
[作者:Stansfeld, PJ; Sansom, MSP,期刊:Structure, 页码:1562-1572 , 文章类型: Review,,卷期:2011年19-11]
- Molecular simulations are an invaluable tool for understanding membrane proteins. Improvements to both hardware and simulation methods have allowed access to physiologically relevant timescales and have permitted the sim...
- Direct Visualization of HIV-1 with Correlative Live-Cell Microscopy and Cryo-Electron Tomography
[作者:Jun, SM; Ke, DX; Debiec, K; Zhao, GP; Meng, X; Ambrose, Z; Gibson, GA; Watkins, SC; Zhang, PJ,期刊:Structure, 页码:1573-1581 , 文章类型: Article,,卷期:2011年19-11]
- Cryo-electron tomography (cryoET) allows 3D visualization of cellular structures at molecular resolution in a close-to-native state and therefore has the potential to help elucidate early events of HIV-1 infection in hos...
- Inhibition of the Pneumococcal Virulence Factor StrH and Molecular Insights into N-Glycan Recognition and Hydrolysis
[作者:Pluvinage, B; Higgins, MA; Abbott, DW; Robb, C; Dalia, AB; Deng, LH; Weiser, JN; Parsons, TB; Fairbanks, AJ; Vocadlo, DJ; Boraston, AB,期刊:Structure, 页码:1603-1614 , 文章类型: Article,,卷期:2011年19-11]
- The complete degradation of N-linked glycans by the pathogenic bacterium Streptococcus pneumoniae is facilitated by the large multimodular cell wall-attached exo-beta-D-N-acetylglucosaminidase StrH. Structural dissection...
- Mechanism of Fibrin(ogen) Forced Unfolding
[作者:Zhmurov, A; Brown, AEX; Litvinov, RI; Dima, RI; Weisel, JW; Barsegov, V,期刊:Structure, 页码:1615-1624 , 文章类型: Article,,卷期:2011年19-11]
- Fibrinogen, upon enzymatic conversion to monomeric fibrin, provides the building blocks for fibrin polymer, the scaffold of blood clots and thrombi. Little has been known about the force-induced unfolding of fibrin(ogen)...
- Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation
[作者:Gingras, AR; Girija, UV; Keeble, AH; Panchal, R; Mitchell, DA; Moody, PCE; Wallis, R,期刊:Structure, 页码:1635-1643 , 文章类型: Article,,卷期:2011年19-11]
- Complement activation contributes directly to health and disease. It neutralizes pathogens and stimulates immune processes. Defects lead to immunodeficiency and autoimmune diseases, whereas inappropriate activation cause...
- Enhanced Selectivity for Sulfatide by Engineered Human Glycolipid Transfer Protein
[作者:Samygina, VR; Popov, AN; Cabo-Bilbao, A; Ochoa-Lizarralde, B; Goni-de-Derio, F; Zhai, XH; Molotkovsky, JG; Patel, DJ; Brown, RE; Malinina, L,期刊:Structure, 页码:1644-1654 , 文章类型: Article,,卷期:2011年19-11]
- Human glycolipid transfer protein (GLTP) fold represents a novel structural motif for lipid binding/transfer and reversible membrane translocation. GLTPs transfer glycosphingolipids (GSLs) that are key regulators of cell...
- Membrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin Activation
[作者:Perera, HD; Ma, YQ; Yang, J; Hirbawi, J; Plow, EF; Qin, J,期刊:Structure, 页码:1664-1671 , 文章类型: Article,,卷期:2011年19-11]
- Kindlin-2 belongs to an emerging class of regulators for heterodimeric (alpha/beta) integrin adhesion receptors. By binding to integrin beta cytoplasmic tail via its C-terminal FERM-like domain, kindlin-2 promotes integr...
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