- Depletion of beta-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development
[作者:Wang, EY; Yeh, SH; Tsai, TF; Huang, HP; Jeng, YM; Lin, WH; Chen, WC; Yeh, KH; Chen, PJ; Chen, DS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18384-18389 , 文章类型: Article,,卷期:2011年108-45]
- Depletion of beta-catenin impairs regeneration of the rapid turn-over gut epithelial cells, but appears dispensable for that of the slow turn-over mature hepatocytes in mice until 1 y of age. As the life span of mature m...
- Piezoelectric materials mimic the function of the cochlear sensory epithelium
[作者:Inaoka, T; Shintaku, H; Nakagawa, T; Kawano, S; Ogita, H; Sakamoto, T; Hamanishi, S; Wada, H; Ito, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18390-18395 , 文章类型: Article,,卷期:2011年108-45]
- Cochlear hair cells convert sound vibration into electrical potential, and loss of these cells diminishes auditory function. In response to mechanical stimuli, piezoelectric materials generate electricity, suggesting tha...
- Early identification of antigen-specific immune responses in vivo by [(18)F]-labeled 3 '-fluoro-3 '-deoxy-thymidine ([(18)F]FLT) PET imaging
[作者:Aarntzen, EHJG; Srinivas, M; De Wilt, JHW; Jacobs, JFM; Lesterhuis, WJ; Windhorst, AD; Troost, EG; Bonenkamp, JJ; van Rossum, MM; Blokx, WAM; Mus, RD; Boerman, OC; Punt, CJA; Figdor, CG; Oyen, WJG; de Vries, IJM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18396-18399 , 文章类型: Article,,卷期:2011年108-45]
- Current biomarkers are unable to adequately predict vaccine-induced immune protection in humans with infectious disease or cancer. However, timely and adequate assessment of antigen-specific immune responses is critical ...
- Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport
[作者:Bai, Y; Ye, LL; Tesar, DB; Song, HC; Zhao, DM; Bjorkman, PJ; Roopenian, DC; Zhu, XP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18406-18411 , 文章类型: Article,,卷期:2011年108-45]
- IgG was traditionally thought to neutralize virions by blocking their attachment to or penetration into mucosal epithelial cells, a common site of exposure to viruses. However, we describe an intracellular neutralizing a...
- Structure-function analysis of varicella-zoster virus glycoprotein H identifies domain-specific roles for fusion and skin tropism
[作者:Vleck, SE; Oliver, SL; Brady, JJ; Blau, HM; Rajamani, J; Sommer, MH; Arvin, AM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18412-18417 , 文章类型: Article,,卷期:2011年108-45]
- Enveloped viruses require membrane fusion for cell entry and replication. For herpesviruses, this event is governed by the multiprotein core complex of conserved glycoproteins (g) B and gH/gL. The recent crystal structur...
- Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella
[作者:Spano, S; Liu, XY; Galan, JE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18418-18423 , 文章类型: Article,,卷期:2011年108-45]
- Unlike broad-host Salmonella serovars, which cause self-limiting disease, Salmonella enterica serovar Typhi can infect only humans causing typhoid fever, a life-threatening systemic disease. The molecular bases for these...
- Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design
[作者:De Luca, F; Benvenuti, M; Carboni, F; Pozzi, C; Rossolini, GM; Mangani, S; Docquier, JD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18424-18429 , 文章类型: Article,,卷期:2011年108-45]
- Class D beta-lactamases with carbapenemase activity are emerging as carbapenem-resistance determinants in Gram-negative bacterial pathogens, mostly Acinetobacter baumannii and Klebsiella pneumoniae. Carbapenemase activit...
- Self-amplifying autocrine actions of BDNF in axon development
[作者:Cheng, PL; Song, AH; Wong, YH; Wang, S; Zhang, X; Poo, MM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18430-18435 , 文章类型: Article,,卷期:2011年108-45]
- A critical step in neuronal development is the formation of axon/dendrite polarity, a process involving symmetry breaking in the newborn neuron. Local self-amplifying processes could enhance and stabilize the initial asy...
- Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation
[作者:Mucha, M; Skrzypiec, AE; Schiavon, E; Attwood, BK; Kucerova, E; Pawlak, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18436-18441 , 文章类型: Article,,卷期:2011年108-45]
- Psychological stress causes adaptive changes in the nervous system directed toward maintaining homoeostasis. These biochemical and structural mechanisms regulate animal behavior, and their malfunction may result in vario...
- Plasticity of astroglial networks in olfactory glomeruli
[作者:Roux, L; Benchenane, K; Rothstein, JD; Bonvento, G; Giaume, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18442-18446 , 文章类型: Article,,卷期:2011年108-45]
- Several recent findings have shown that neurons as well as astrocytes are organized into networks. Indeed, astrocytes are interconnected through connexin-formed gap junction channels allowing exchanges of ions and signal...
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