- alpha-Synuclein fate is determined by USP9X-regulated monoubiquitination
[作者:Rott, R; Szargel, R; Haskin, J; Bandopadhyay, R; Lees, AJ; Shani, V; Engelender, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18666-18671 , 文章类型: Article,,卷期:2011年108-46]
- alpha-Synuclein is central to the pathogenesis of Parkinson disease (PD). Mutations as well as accumulation of alpha-synuclein promote the death of dopaminergic neurons and the formation of Lewy bodies. alpha-Synuclein i...
- Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate
[作者:Wu, XD; Bradley, MJ; Cai, YY; Kuemmel, D; De La Cruz, EM; Barr, FA; Reinisch, KM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18672-18677 , 文章类型: Article,,卷期:2011年108-46]
- Rab GTPases are key regulators of membrane traffic pathways within eukaryotic cells. They are specifically activated by guanine nucleotide exchange factors (GEFs), which convert them from their "inactive" GDP-bound form ...
- Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1 alpha/ERR gamma complex
[作者:Devarakonda, S; Gupta, K; Chalmers, MJ; Hunt, JF; Griffin, PR; Van Duyne, GD; Spiegelman, BM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18678-18683 , 文章类型: Article,,卷期:2011年108-46]
- Peroxisome proliferator activated receptor (PPAR) gamma coactivator-1 alpha (PGC-1 alpha) is a potent transcriptional coactivator of oxidative metabolism and is induced in response to a variety of environmental cues. It ...
- Activation mechanism of the beta(2)-adrenergic receptor
[作者:Dror, RO; Arlow, DH; Maragakis, P; Mildorf, TJ; Pan, AC; Xu, HF; Borhani, DW; Shaw, DE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18684-18689 , 文章类型: Article,,卷期:2011年108-46]
- A third of marketed drugs act by binding to a G-protein-coupled receptor (GPCR) and either triggering or preventing receptor activation. Although recent crystal structures have provided snapshots of both active and inact...
- Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process
[作者:Kirchberg, K; Kim, TY; Moller, M; Skegro, D; Raju, GD; Granzin, J; Buldt, G; Schlesinger, R; Alexiev, U,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18690-18695 , 文章类型: Article,,卷期:2011年108-46]
- Arrestins are regulatory molecules for G-protein coupled receptor function. In visual rhodopsin, selective binding of arrestin to the cytoplasmic side of light-activated, phosphorylated rhodopsin (P-Rh(star)) terminates ...
- Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice
[作者:Yang, RY; Yu, L; Graham, JL; Hsu, DK; Lloyd, KCK; Havel, PJ; Liu, FT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18696-18701 , 文章类型: Article,,卷期:2011年108-46]
- The breakdown of triglycerides, or lipolysis, is a tightly controlled process that regulates fat mobilization in accord with an animal's energy needs. It is well established that lipolysis is stimulated by hormones that ...
- Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance
[作者:Gillet, JP; Calcagno, AM; Varma, S; Marino, M; Green, LJ; Vora, MI; Patel, C; Orina, JN; Eliseeva, TA; Singal, V; Padmanabhan, R; Davidson, B; Ganapathi, R; Sood, AK; Rueda, BR; Ambudkar, SV; Gottesman, MM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18708-18713 , 文章类型: Article,,卷期:2011年108-46]
- Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has been uncertain. Using a state-of-the-art Taqman-based quantitative RT-PCR assay...
- Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions
[作者:Saha, K; Mei, Y; Reisterer, CM; Pyzocha, NK; Yang, J; Muffat, J; Davies, MC; Alexander, MR; Langer, R; Anderson, DG; Jaenisch, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18714-18719 , 文章类型: Article,,卷期:2011年108-46]
- The current gold standard for the culture of human pluripotent stem cells requires the use of a feeder layer of cells. Here, we develop a spatially defined culture system based on UV/ozone radiation modification of typic...
- Inferring the structure and dynamics of interactions in schooling fish
[作者:Katz, Y; Tunstrom, K; Ioannou, CC; Huepe, C; Couzin, ID,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18720-18725 , 文章类型: Article,,卷期:2011年108-46]
- Determining individual-level interactions that govern highly coordinated motion in animal groups or cellular aggregates has been a long-standing challenge, central to understanding the mechanisms and evolution of collect...
- Inferring the rules of interaction of shoaling fish
[作者:Herbert-Read, JE; Perna, A; Mann, RP; Schaerf, TM; Sumpter, DJT; Ward, AJW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18726-18731 , 文章类型: Article,,卷期:2011年108-46]
- Collective motion, where large numbers of individuals move synchronously together, is achieved when individuals adopt interaction rules that determine how they respond to their neighbors' movements and positions. These r...
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