- Dynamic Nucleosome-Depleted Regions at Androgen Receptor Enhancers in the Absence of Ligand in Prostate Cancer Cells
[作者:Andreu-Vieyra, C; Lai, J; Berman, BP; Frenkel, B; Jia, L; Jones, PA; Coetzee, GA,期刊:Molecular and Cellular Biology, 页码:4648-4662 , 文章类型: Article,,卷期:2011年31-23]
- Nucleosome positioning at transcription start sites is known to regulate gene expression by altering DNA accessibility to transcription factors; however, its role at enhancers is poorly understood. We investigated nucleo...
- Identification of DHX33 as a Mediator of rRNA Synthesis and Cell Growth
[作者:Zhang, YD; Forys, JT; Miceli, AP; Gwinn, AS; Weber, JD,期刊:Molecular and Cellular Biology, 页码:4676-4691 , 文章类型: Article,,卷期:2011年31-23]
- In this report, we employed a lentiviral RNA interference screen to discover nucleolar DEAD/DEAH-box helicases involved in RNA polymerase I (Pol I)-mediated transcriptional activity. Our screen identified DHX33 as an imp...
- Osteoclast Progenitors Reside in the Peroxisome Proliferator-Activated Receptor gamma-Expressing Bone Marrow Cell Population
[作者:Wei, W; Zeve, D; Wang, XQ; Du, Y; Tang, W; Dechow, PC; Graff, JM; Wan, YH,期刊:Molecular and Cellular Biology, 页码:4692-4705 , 文章类型: Article,,卷期:2011年31-23]
- Osteoclasts are bone-resorbing cells essential for skeletal development, homeostasis, and regeneration. They derive from hematopoietic progenitors in the monocyte/macrophage lineage and differentiate in response to RANKL...
- Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by beta-Catenin
[作者:Wei, W; Zeve, D; Suh, JM; Wang, XQ; Du, Y; Zerwekh, JE; Dechow, PC; Graff, JM; Wan, YH,期刊:Molecular and Cellular Biology, 页码:4706-4719 , 文章类型: Article,,卷期:2011年31-23]
- Wnt/beta-catenin signaling is a critical regulator of skeletal physiology. However, previous studies have mainly focused on its roles in osteoblasts, while its specific function in osteoclasts is unknown. This is a clini...
- SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities
[作者:Peng, LR; Yuan, ZG; Ling, HB; Fukasawa, K; Robertson, K; Olashaw, N; Koomen, J; Chen, JD; Lane, WS; Seto, E,期刊:Molecular and Cellular Biology, 页码:4720-4734 , 文章类型: Article,,卷期:2011年31-23]
- DNA methylation and histone acetylation/deacetylation are distinct biochemical processes that control gene expression. While DNA methylation is a common epigenetic signal that inhibits gene transcription, histone deacety...
- Mammalian Ino80 Mediates Double-Strand Break Repair through Its Role in DNA End Strand Resection
[作者:Gospodinov, A; Vaissiere, T; Krastev, DB; Legube, G; Anachkova, B; Herceg, Z,期刊:Molecular and Cellular Biology, 页码:4735-4745 , 文章类型: Article,,卷期:2011年31-23]
- Chromatin modifications/remodeling are important mechanisms by which cells regulate various functions through providing accessibility to chromatin DNA. Recent studies implicated INO80, a conserved chromatin-remodeling co...
- Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2
[作者:Wu, C; So, J; Davis-Dusenbery, BN; Qi, HH; Bloch, DB; Shi, Y; Lagna, G; Hata, A,期刊:Molecular and Cellular Biology, 页码:4760-4774 , 文章类型: Article,,卷期:2011年31-23]
- Hypoxia contributes to the pathogenesis of various human diseases, including pulmonary artery hypertension (PAH), stroke, myocardial or cerebral infarction, and cancer. For example, acute hypoxia causes selective pulmona...
- Survival and Differentiation of Mammary Epithelial Cells in Mammary Gland Development Require Nuclear Retention of Id2 Due to RANK Signaling
[作者:Kim, NS; Kim, HT; Kwon, MC; Choi, SW; Kim, YY; Yoon, KJ; Koo, BK; Kong, MP; Shin, J; Cho, Y; Kong, YY,期刊:Molecular and Cellular Biology, 页码:4775-4788 , 文章类型: Article,,卷期:2011年31-23]
- RANKL plays an essential role in mammary gland development during pregnancy. However, the molecular mechanism by which RANK signaling leads to mammary gland development is largely unknown. We report here that RANKL stimu...
- Functional Elements in Initiation Factors 1, 1A, and 2 beta Discriminate against Poor AUG Context and Non-AUG Start Codons
[作者:Martin-Marcos, P; Cheung, YN; Hinnebusch, AG,期刊:Molecular and Cellular Biology, 页码:4814-4831 , 文章类型: Article,,卷期:2011年31-23]
- Yeast eIF1 inhibits initiation at non-AUG triplets, but it was unknown whether it also discriminates against AUGs in suboptimal context. As in other eukaryotes, the yeast gene encoding eIF1 (SUI1) contains an AUG in poor...
- The NF90/NF45 Complex Participates in DNA Break Repair via Nonhomologous End Joining
[作者:Shamanna, RA; Hoque, M; Lewis-Antes, A; Azzam, EI; Lagunoff, D; Pe'ery, T; Mathews, MB,期刊:Molecular and Cellular Biology, 页码:4832-4843 , 文章类型: Article,,卷期:2011年31-23]
- Nuclear factor 90 (NF90), an RNA-binding protein implicated in the regulation of gene expression, exists as a heterodimeric complex with NF45. We previously reported that depletion of the NF90/NF45 complex results in a m...
- Plk1 Phosphorylation of Orc2 Promotes DNA Replication under Conditions of Stress
[作者:Song, B; Liu, XS; Davis, K; Liu, XQ,期刊:Molecular and Cellular Biology, 页码:4844-4856 , 文章类型: Article,,卷期:2011年31-23]
- Polo-like kinase 1 (Plk1) plays pivotal roles in mitosis; however, little is known about its function in S phase. In this study, we show that inhibition of Plk1 impairs DNA replication and results in slow S-phase progres...
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