- MDM2 Regulates Vascular Endothelial Growth Factor mRNA Stabilization in Hypoxia
[作者:Zhou, S; Gu, LB; He, J; Zhang, HL; Zhou, MX,期刊:Molecular and Cellular Biology, 页码:4928-4937 , 文章类型: Article,,卷期:2011年31-24]
- Expression of vascular endothelial growth factor (VEGF) increases in cancer cells during hypoxia. Herein, we report that the MDM2 oncoprotein plays a role in hypoxia-mediated VEGF upregulation. In studying the characteri...
- Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD(+) Redox Homeostasis in Cancer Cells
[作者:Fan, J; Hitosugi, T; Chung, TW; Xie, JX; Ge, QY; Gu, TL; Polakiewicz, RD; Chen, GZ; Boggon, TJ; Lonial, S; Khuri, FR; Kang, SM; Chen, J,期刊:Molecular and Cellular Biology, 页码:4938-4950 , 文章类型: Article,,卷期:2011年31-24]
- The Warburg effect describes an increase in aerobic glycolysis and enhanced lactate production in cancer cells. Lactate dehydrogenase A (LDH-A) regulates the last step of glycolysis that generates lactate and permits the...
- Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage
[作者:Cheng, Q; Cross, B; Li, BZ; Chen, LH; Li, ZY; Chen, JD,期刊:Molecular and Cellular Biology, 页码:4951-4963 , 文章类型: Article,,卷期:2011年31-24]
- MDM2 is a major regulator of p53 by acting as a ubiquitin E3 ligase. The central acidic domain and C-terminal RING domain of MDM2 are both indispensable for ubiquitination of p53. Our previous study suggested that ATM ph...
- Global Phosphoproteome Profiling Reveals Unanticipated Networks Responsive to Cisplatin Treatment of Embryonic Stem Cells
[作者:Pines, A; Kelstrup, CD; Vrouwe, MG; Puigvert, JC; Typas, D; Misovic, B; de Groot, A; von Stechow, L; van de Water, B; Danen, EHJ; Vrieling, H; Mullenders, LHF; Olsen, JV,期刊:Molecular and Cellular Biology, 页码:4964-4977 , 文章类型: Article,,卷期:2011年31-24]
- Cellular responses to DNA-damaging agents involve the activation of various DNA damage signaling and transduction pathways. Using quantitative and high-resolution tandem mass spectrometry, we determined global changes in...
- Superresolution Fluorescence Imaging of Mitochondrial Nucleoids Reveals Their Spatial Range, Limits, and Membrane Interaction
[作者:Brown, TA; Tkachuk, AN; Shtengel, G; Kopek, BG; Bogenhagen, DF; Hess, HF; Clayton, DA,期刊:Molecular and Cellular Biology, 页码:4994-5010 , 文章类型: Article,,卷期:2011年31-24]
- A fundamental objective in molecular biology is to understand how DNA is organized in concert with various proteins, RNA, and biological membranes. Mitochondria maintain and express their own DNA (mtDNA), which is arrang...
- Calcineurin Mediates the Gonadotropin-Releasing Hormone Effect on Expression of Both Subunits of the Follicle-Stimulating Hormone through Distinct Mechanisms
[作者:Pnueli, L; Luo, M; Wang, SH; Naor, Z; Melamed, P,期刊:Molecular and Cellular Biology, 页码:5023-5036 , 文章类型: Article,,卷期:2011年31-24]
- Gonadotropin-releasing hormone (GnRH) regulates the expression of all three gonadotropin genes, encoding the common alpha subunit (alpha GSU) and hormone-specific beta subunits, through the activation of several signal t...
- Inhibition of the Single Downstream Target BAG1 Activates the Latent Apoptotic Potential of MYC
[作者:Zhang, XY; Pfeiffer, HK; Mellert, HS; Stanek, TJ; Sussman, RT; Kumari, A; Yu, DN; Rigoutsos, I; Thomas-Tikhonenko, A; Seidel, HE; Chodosh, LA; Packham, G; Baserga, R; McMahon, SB,期刊:Molecular and Cellular Biology, 页码:5037-5045 , 文章类型: Article,,卷期:2011年31-24]
- Aberrant MYC expression is a common oncogenic event in human cancer. Paradoxically, MYC can either drive cell cycle progression or induce apoptosis. The latent ability of MYC to induce apoptosis has been termed "intrinsi...
- The Transcriptional Coactivator Cbp Regulates Self-Renewal and Differentiation in Adult Hematopoietic Stem Cells
[作者:Chan, WI; Hannah, RL; Dawson, MA; Pridans, C; Foster, D; Joshi, A; Gottgens, B; Van Deursen, JM; Huntly, BJP,期刊:Molecular and Cellular Biology, 页码:5046-5060 , 文章类型: Article,,卷期:2011年31-24]
- The transcriptional coactivator Cbp plays an important role in a wide range of cellular processes, including proliferation, differentiation, and apoptosis. Although studies have shown its requirement for hematopoietic st...
- Type VI Adenylyl Cyclase Regulates Neurite Extension by Binding to Snapin and Snap25
[作者:Wu, CS; Lin, JT; Chien, CL; Chang, WC; Lai, HL; Chang, CP; Chern, YJ,期刊:Molecular and Cellular Biology, 页码:4874-4886 , 文章类型: Article,,卷期:2011年31-24]
- 3'-5'-Cyclic AMP (cAMP) is an important second messenger which regulates neurite outgrowth. We demonstrate here that type VI adenylyl cyclase (AC6), an enzyme which catalyzes cAMP synthesis, regulates neurite outgrowth b...
- beta-Arrestin2 Plays Permissive Roles in the Inhibitory Activities of RGS9-2 on G Protein-Coupled Receptors by Maintaining RGS9-2 in the Open Conformation
[作者:Zheng, M; Cheong, SY; Min, C; Jin, M; Cho, DI; Kim, KM,期刊:Molecular and Cellular Biology, 页码:4887-4901 , 文章类型: Article,,卷期:2011年31-24]
- Together with G protein-coupled receptor (GPCR) kinases (GRKs) and beta-arrestins, RGS proteins are the major family of molecules that control the signaling of GPCRs. The expression pattern of one of these RGS family mem...
- A Critical Role of Mitochondrial Phosphatase Ptpmt1 in Embryogenesis Reveals a Mitochondrial Metabolic Stress-Induced Differentiation Checkpoint in Embryonic Stem Cells
[作者:Shen, JH; Liu, X; Yu, WM; Liu, J; Nibbelink, MG; Guo, CY; Finkel, T; Qu, CK,期刊:Molecular and Cellular Biology, 页码:4902-4916 , 文章类型: Article,,卷期:2011年31-24]
- Mitochondria are highly dynamic organelles that play multiple roles in cells. How mitochondria cooperatively modulate embryonic stem (ES) cell function during development is not fully understood. Global disruption of Ptp...
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