- Thrombotic Microangiopathy with Targeted Cancer Agents
[作者：Blake-Haskins, JA; Lechleider, RJ; Kreitman, RJ,期刊：Clinical Cancer Research, 页码：5858-5866 , 文章类型： Review，,卷期：2011年17-18]
- Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are clinically similar disorders characterized by microvascular thrombosis, hemolysis, thrombocytopenia, and end-organ damage. Although they m...
- Resection of Non-Small Cell Lung Cancers Reverses Tumor-Induced Gene Expression Changes in the Peripheral Immune System
[作者：Kossenkov, AV; Vachani, A; Chang, C; Nichols, C; Billouin, S; Horng, W; Rom, WN; Albelda, SM; Showe, MK; Showe, LC,期刊：Clinical Cancer Research, 页码：5867-5877 , 文章类型： Article，,卷期：2011年17-18]
- Purpose: To characterize the interactions of non-small cell lung cancer (NSCLC) tumors with the immune system at the level of mRNA and microRNA (miRNA) expression and to define expression signatures that characterize the...
- ERG Status Is Unrelated to PSA Recurrence in Radically Operated Prostate Cancer in the Absence of Antihormonal Therapy
[作者：Minner, S; Enodien, M; Sirma, H; Luebke, AM; Krohn, A; Mayer, PS; Simon, R; Tennstedt, P; Muller, J; Scholz, L; Brase, JC; Liu, AY; Schluter, H; Pantel, K; Schumacher, U; Bokemeyer, C; Steuber, T; Graefen, M; Sauter, G; Schlomm, T,期刊：Clinical Cancer Research, 页码：5878-5888 , 文章类型： Article，,卷期：2011年17-18]
- Purpose: About 50% of prostate cancers have TMPRSS2-ERG fusions with concurrent ERG overexpression. The aim of this study was to determine whether clinical differences exist between ERG-positive and ERG-negative cancers ...
- Characterization of a Cleavage Stimulation Factor, 3 ' pre-RNA, Subunit 2, 64 kDa (CSTF2) as a Therapeutic Target for Lung Cancer
[作者：Aragaki, M; Takahashi, K; Akiyama, H; Tsuchiya, E; Kondo, S; Nakamura, Y; Daigo, Y,期刊：Clinical Cancer Research, 页码：5889-5900 , 文章类型： Article，,卷期：2011年17-18]
- Purpose: This study aims to discover novel biomarkers and therapeutic targets for lung cancers. Experimental Design: We screened for genes showing elevated expression in the majority of lung cancers by genome-wide gene e...
- Combining EGFR and mTOR Blockade for the Treatment of Epithelioid Sarcoma
[作者：Xie, XB; Ghadimi, MPH; Young, ED; Belousov, R; Zhu, QS; Liu, JH; Lopez, G; Colombo, C; Peng, TS; Reynoso, D; Hornick, JL; Lazar, AJ; Lev, D,期刊：Clinical Cancer Research, 页码：5901-5912 , 文章类型： Article，,卷期：2011年17-18]
- Purpose: Molecular deregulations underlying epithelioid sarcoma (ES) progression are poorly understood yet critically needed to develop new therapies. Epidermal growth factor receptor (EGFR) is over-expressed in ES; usin...
- Resistance to CYP17A1 Inhibition with Abiraterone in Castration-Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants
[作者：Mostaghel, EA; Marck, BT; Plymate, SR; Vessella, RL; Balk, S; Matsumoto, AM; Nelson, PS; Montgomery, RB,期刊：Clinical Cancer Research, 页码：5913-5925 , 文章类型： Article，,卷期：2011年17-18]
- Purpose: Abiraterone is a potent inhibitor of the steroidogenic enzyme CYP17A1 and suppresses tumor growth in patients with castration-resistant prostate cancer (CRPC). The effectiveness of abiraterone in reducing tumor ...
- Targeting Human B-cell Malignancies through Ig Light Chain-Specific Cytotoxic T Lymphocytes
[作者：Weng, JS; Cha, SC; Matsueda, S; Alatrash, G; Popescu, MS; Yi, Q; Molldrem, JJ; Wang, M; Neelapu, SS; Kwak, LW,期刊：Clinical Cancer Research, 页码：5945-5952 , 文章类型： Article，,卷期：2011年17-18]
- Purpose: The variable regions of Ig (idiotype, Id) expressed by malignant B cells can be used as tumor-specific antigens that induce humoral and cellular immunity. However, epitopes derived from Id that stimulate human C...
- Curcumin Treatment Suppresses IKK beta Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study
[作者：Kim, SG; Veena, MS; Basak, SK; Han, E; Tajima, T; Gjertson, DW; Starr, J; Eidelman, O; Pollard, HB; Srivastava, M; Srivatsan, ES; Wang, MB,期刊：Clinical Cancer Research, 页码：5953-5961 , 文章类型： Article，,卷期：2011年17-18]
- Purpose: To determine whether curcumin would inhibit I kappa B kinase beta (IKK beta) kinase activity and suppress expression of proinflammatory cytokines in head and neck squamous cell carcinoma cancer (HNSCC) patients....
- Preclinical Pharmacokinetics and Safety of Sym004: A Synergistic Antibody Mixture Directed against Epidermal Growth Factor Receptor
[作者：Skartved, NJO; Jacobsen, HJ; Pedersen, MW; Jensen, PF; Sen, JW; Jorgensen, TK; Hey, A; Kragh, M,期刊：Clinical Cancer Research, 页码：5962-5972 , 文章类型： Article，,卷期：2011年17-18]
- Purpose: Sym004 is a novel therapeutic antibody mixture product comprising two unmarketed monoclonal antibodies (mAb) targeting the epidermal growth factor receptor (EGFR). In previous preclinical proof-of-concept studie...
- ABT-737 Induces Apoptosis in Mantle Cell Lymphoma Cells with a Bcl-2(high)/Mcl-1(low) Profile and Synergizes with Other Antineoplastic Agents
[作者：Touzeau, C; Dousset, C; Bodet, L; Gomez-Bougie, P; Bonnaud, S; Moreau, A; Moreau, P; Pellat-Deceunynk, C; Amiot, M; Le Gouill, S,期刊：Clinical Cancer Research, 页码：5973-5981 , 文章类型： Article，,卷期：2011年17-18]
- Purpose: Mantle cell lymphoma (MCL) is considered to be incurable. ABT-737 is a BH3 mimetic that targets Bcl-2, which is overexpressed in MCL and implicated in drug resistance. The present work investigated the antitumor...
- Automated Volumetric Growth Plate Measurement Using Magnetic Resonance Imaging for Monitoring Skeletal Toxicity in Children Treated on Investigational Drug Trials
[作者：Kim, A; Dombi, E; Solomon, J; Fox, E; Balis, FM; Widemann, BC,期刊：Clinical Cancer Research, 页码：5982-5990 , 文章类型： Article，,卷期：2011年17-18]
- Purpose: Targeted anticancer agents have been reported to have side effects on the skeletal system such as thickening of the epiphyseal growth plate in preclinical models of juvenile, but not mature, animals. Careful eva...
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