- BEAMing Sheds Light on Drug Resistance
[作者：Lauring, J; Park, BH,期刊：Clinical Cancer Research, 页码：7508-7510 , 文章类型： Article，,卷期：2011年17-24]
- Targeted therapies against somatically altered genes are currently used for the treatment of many human cancers. The nascent technology known as BEAMing has the potential to increase the clinical utility of these agents ...
- Role of BRAF in Thyroid Oncogenesis
[作者：Caronia, LM; Phay, JE; Shah, MH,期刊：Clinical Cancer Research, 页码：7511-7517 , 文章类型： Article，,卷期：2011年17-24]
- BRAF, a cytoplasmic serine-threonine protein kinase, plays a critical role in cell signaling as an activator within the mitogen-activated protein kinase (MAPK) pathway. The most common BRAF mutation is the V600E transver...
- Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays
[作者：Manfredi, MG; Ecsedy, JA; Chakravarty, A; Silverman, L; Zhang, MK; Hoar, KM; Stroud, SG; Chen, W; Shinde, V; Huck, JJ; Wysong, DR; Janowick, DA; Hyer, ML; Leroy, PJ; Gershman, RE; Silva, MD; Germanos, MS; Bolen, JB; Claiborne, CF; Sells, TB,期刊：Clinical Cancer Research, 页码：7614-7624 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology clinical trials. We developed three novel assays to quantitatively ...
- Iron Deprivation Suppresses Hepatocellular Carcinoma Growth in Experimental Studies
[作者：Ba, Q; Hao, M; Huang, H; Hou, JM; Ge, SC; Zhang, ZZ; Yin, J; Chu, RA; Jiang, HL; Wang, FD; Chen, KX; Liu, H; Wang, H,期刊：Clinical Cancer Research, 页码：7625-7633 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death, and iron overload is a significant risk factor in the development of HCC. In this study, we investigated the potential appli...
- Pharmacodynamic Study Using FLT PET/CT in Patients with Renal Cell Cancer and Other Solid Malignancies Treated with Sunitinib Malate
[作者：Liu, G; Jeraj, R; Vanderhoek, M; Perlman, S; Kolesar, J; Harrison, M; Simoncic, U; Eickhoff, J; Carmichael, L; Chao, B; Marnocha, R; Ivy, P; Wilding, G,期刊：Clinical Cancer Research, 页码：7634-7644 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: To characterize proliferative changes in tumors during the sunitinib malate exposure/withdrawal using 3'-deoxy-3'-[(18)F] fluorothymidine (FLT) positron emission tomography (PET)/computed tomography (CT) imaging...
- 2-(3-{1-Carboxy-5-[(6-[(18)F]Fluoro-Pyridine-3-Carbonyl)-Amino]-Pentyl}-Ureido)-Pentanedioic Acid, [(18)F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate Cancer
[作者：Chen, Y; Pullambhatla, M; Foss, CA; Byun, Y; Nimmagadda, S; Senthamizhchelvan, S; Sgouros, G; Mease, RC; Pomper, MG,期刊：Clinical Cancer Research, 页码：7645-7653 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: We have synthesized and evaluated in vivo 2-(3-{1-carboxy-5-[(6-[(18)F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioicacid, [(18)F]DCFPyL, as a potential imaging agent for the prostate-specific m...
- Overexpression of ZEB2 at the Invasion Front of Colorectal Cancer Is an Independent Prognostic Marker and Regulates Tumor Invasion In Vitro
[作者：Kahlert, C; Lahes, S; Radhakrishnan, P; Dutta, S; Mogler, C; Herpel, E; Brand, K; Steinert, G; Schneider, M; Mollenhauer, M; Reissfelder, C; Klupp, F; Fritzmann, J; Wunder, C; Benner, A; Kloor, M; Huth, C; Contin, P; Ulrich, A; Koch, M; Weitz, J,期刊：Clinical Cancer Research, 页码：7654-7663 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and dissemination. EMT occurs predominantly at the tumor edge where it is induced by cytokines, the extracellular matrix environm...
- [(18)F]-3 ' Deoxy-3 '-Fluorothymidine Positron Emission Tomography and Breast Cancer Response to Docetaxel
[作者：Contractor, KB; Kenny, LM; Stebbing, J; Rosso, L; Ahmad, R; Jacob, J; Challapalli, A; Turkheimer, F; Al-Nahhas, A; Sharma, R; Coombes, RC; Aboagye, EO,期刊：Clinical Cancer Research, 页码：7664-7672 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: To establish biomarkers indicating clinical response to taxanes, we determined whether early changes in [(18)F]-3'deoxy-3'-fluorothymidine positron emission tomography (FLT-PET) can predict benefit from docetaxe...
- Use of [(11)C]Choline PET-CT as a Noninvasive Method for Detecting Pelvic Lymph Node Status from Prostate Cancer and Relationship with Choline Kinase Expression
[作者：Contractor, K; Challapalli, A; Barwick, T; Winkler, M; Hellawell, G; Hazell, S; Tomasi, G; Al-Nahhas, A; Mapelli, P; Kenny, LM; Tadrous, P; Coombes, RC; Aboagye, EO; Mangar, S,期刊：Clinical Cancer Research, 页码：7673-7683 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: To evaluate the accuracy and biological basis for [(11)C]choline-PET-CT in the nodal staging of high risk localized prostate cancer patients.Experimental Design: Twenty-eight patients underwent dynamic [(11)C] c...
- miRNA Expression Profiling Enables Risk Stratification in Archived and Fresh Neuroblastoma Tumor Samples
[作者：De Preter, K; Mestdagh, P; Vermeulen, J; Zeka, F; Naranjo, A; Bray, I; Castel, V; Chen, CF; Drozynska, E; Eggert, A; Hogarty, MD; Ewalzycka-Swieszewska; London, WB; Noguera, R; Piqueras, M; Bryan, K; Schowe, B; van Sluis, P; Molenaar, JJ; Schramm, A; Schulte, JH; Stallings, RL; Versteeg, R; Laureys, G; Van Roy, N; Speleman, F; Vandesompele, J,期刊：Clinical Cancer Research, 页码：7684-7692 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: More accurate assessment of prognosis is important to further improve the choice of risk-related therapy in neuroblastoma (NB) patients. In this study, we aimed to establish and validate a prognostic miRNA signa...
- Predicting IGF-1R Therapy Response in Bone Sarcomas: Immuno-SPECT Imaging with Radiolabeled R1507
[作者：Fleuren, EDG; Versleijen-Jonkers, YMH; de Luijtgaarden, ACMV; Molkenboer-Kuenen, JDM; Heskamp, S; Roeffen, MHS; van Laarhoven, HWM; Houghton, PJ; Oyen, WJG; Boerman, OC; van der Graaf, WTA,期刊：Clinical Cancer Research, 页码：7693-7703 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: To investigate whether indium-111-labeled R1507 ((111)In-R1507) immuno-SPECT (single-photon emission computed tomography), a novel noninvasive, in vivo screening method to visualize membranous insulin-like growt...
- Chromosomal Instability Substantiates Poor Prognosis in Patients with Diffuse Large B-cell Lymphoma
[作者：Bakhoum, SF; Danilova, OV; Kaur, P; Levy, NB; Compton, DA,期刊：Clinical Cancer Research, 页码：7704-7711 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: The specific role of chromosomal instability (CIN) in tumorigenesis has been a matter of conjecture. In part, this is due to the challenge of directly observing chromosome mis-segregation events as well as the i...
- Chondrolectin Is a Novel Diagnostic Biomarker and a Therapeutic Target for Lung Cancer
[作者：Masuda, K; Takano, A; Oshita, H; Akiyama, H; Tsuchiya, E; Kohno, N; Nakamura, Y; Daigo, Y,期刊：Clinical Cancer Research, 页码：7712-7722 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: This study aims to identify molecules that might be useful as diagnostic/prognostic biomarkers and as targets for the development of new molecular therapies for lung cancer.Experimental Design: We screened for g...
- A Let-7 MicroRNA SNP in the KRAS 3 ' UTR Is Prognostic in Early-Stage Colorectal Cancer
[作者：Smits, KM; Paranjape, T; Nallur, S; Wouters, KAD; Weijenberg, MP; Schouten, LJ; van den Brandt, PA; Bosman, FT; Weidhaas, JB; van Engeland, M,期刊：Clinical Cancer Research, 页码：7723-7731 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: Colorectal cancer (CRC) is a common cause of death worldwide. Tumor-node-metastasissystem stage is currently used to guide therapy decisions but lacks precision. Prognostic biomarkers are needed to refine strati...
- A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma
[作者：Eigentler, TK; Weide, B; de Braud, F; Spitaleri, G; Romanini, A; Pflugfelder, A; Gonzalez-Iglesias, R; Tasciotti, A; Giovannoni, L; Schwager, K; Lovato, V; Kaspar, M; Trachsel, E; Menssen, HD; Neri, D; Garbe, C,期刊：Clinical Cancer Research, 页码：7732-7742 , 文章类型： Article，,卷期：2011年17-24]
- Purpose: L19-IL2 is an immunocytokine composed of an antibody fragment specific to the EDB domain of fibronectin, a tumor angiogenesis marker, and of human interleukin-2 (IL2). L19-IL2 delivers IL2 to the tumor site expl...
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