- B1a B Lymphocytes Are Atheroprotective by Secreting Natural IgM That Increases IgM Deposits and Reduces Necrotic Cores in Atherosclerotic Lesions
[作者:Kyaw, T; Tay, C; Krishnamurthi, S; Kanellakis, P; Agrotis, A; Tipping, P; Bobik, A; Toh, BH,期刊:Circulation Research, 页码:830-NIL_34 , 文章类型: Article,,卷期:2011年109-8]
- Rationale: Aggravated atherosclerosis in B lymphocyte-deficient chimeric mice and reduced atherosclerosis after transfer of unfractionated spleen B lymphocytes into splenectomized mice have led to the widely held notion ...
- Distribution and Functional Role of Inositol 1,4,5-trisphosphate Receptors in Mouse Sinoatrial Node
[作者:Ju, YK; Liu, J; Lee, BH; Lai, DN; Woodcock, EA; Lei, M; Cannell, MB; Allen, DG,期刊:Circulation Research, 页码:848-NIL_66 , 文章类型: Article,,卷期:2011年109-8]
- Rationale: Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) have been implicated in the generation of arrhythmias and cardiac muscle nuclear signaling. However, in the mammalian sinoatrial node (SAN), where the heart bea...
- Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension
[作者:Tamosiuniene, R; Tian, W; Dhillon, G; Wang, LJ; Sung, YK; Gera, L; Patterson, AJ; Agrawal, R; Rabinovitch, M; Ambler, K; Long, CS; Voelkel, NF; Nicolls, MR,期刊:Circulation Research, 页码:867-NIL_120 , 文章类型: Article,,卷期:2011年109-8]
- Rationale: Pulmonary arterial hypertension (PAH) is an incurable disease associated with viral infections and connective tissue diseases. The relationship between inflammation and disease pathogenesis in these disorders ...
- MicroRNA-133 Controls Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and Vascular Remodeling In Vivo
[作者:Torella, D; Iaconetti, C; Catalucci, D; Ellison, GM; Leone, A; Waring, CD; Bochicchio, A; Vicinanza, C; Aquila, I; Curcio, A; Condorelli, G; Indolfi, C,期刊:Circulation Research, 页码:880-NIL_146 , 文章类型: Article,,卷期:2011年109-8]
- Rationale: MicroRNA (miR)-1 and -133 play a crucial role in skeletal and cardiac muscle biology and pathophysiology. However, their expression and regulation in vascular cell physiology and disease is currently unknown.O...
- Transplantation of Human Pericyte Progenitor Cells Improves the Repair of Infarcted Heart Through Activation of an Angiogenic Program Involving Micro-RNA-132
[作者:Katare, R; Riu, F; Mitchell, K; Gubernator, M; Campagnolo, P; Cui, YX; Fortunato, O; Avolio, E; Cesselli, D; Beltrami, AP; Angelini, G; Emanueli, C; Madeddu, P,期刊:Circulation Research, 页码:894-NIL_191 , 文章类型: Article,,卷期:2011年109-8]
- Rationale: Pericytes are key regulators of vascular maturation, but their value for cardiac repair remains unknown.Objective: We investigated the therapeutic activity and mechanistic targets of saphenous vein-derived per...
- Mesenchymal Stem Cells Biology, Pathophysiology, Translational Findings, and Therapeutic Implications for Cardiac Disease
[作者:Williams, AR; Hare, JM,期刊:Circulation Research, 页码:923-940 , 文章类型: Review,,卷期:2011年109-8]
- Mesenchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-renewal and differentiation with a broad tissue distribution. Initially described in bone marrow, MSCs have the capacity to differen...
- Imaging Guiding the Clinical Translation of Cardiac Stem Cell Therapy
[作者:Nguyen, PK; Lan, F; Wang, YM; Wu, JC,期刊:Circulation Research, 页码:962-979 , 文章类型: Review,,卷期:2011年109-8]
- Stem cells have been touted as the holy grail of medical therapy, with promises to regenerate cardiac tissue, but it appears the jury is still out on this novel therapy. Using advanced imaging technology, scientists have...
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