- Rip2 Deficiency Leads to Increased Atherosclerosis Despite Decreased Inflammation
[作者:Levin, MC; Jirholt, P; Wramstedt, A; Johansson, ME; Lundberg, AM; Trajkovska, MG; Stahlman, M; Fogelstrand, P; Brisslert, M; Fogelstrand, L; Yan, ZQ; Hansson, GK; Bjorkbacka, H; Olofsson, SO; Boren, J,期刊:Circulation Research, 页码:1210-NIL_50 , 文章类型: Article,,卷期:2011年109-11]
- Rationale: The innate immune system and in particular the pattern-recognition receptors Toll-like receptors have recently been linked to atherosclerosis. Consequently, inhibition of various signaling molecules downstream...
- Role of K(ATP) Channels in the Maintenance of Ventricular Fibrillation in Cardiomyopathic Human Hearts
[作者:Farid, TA; Nair, K; Masse, S; Azam, MA; Maguy, A; Lai, PFH; Umapathy, K; Dorian, P; Chauhan, V; Varro, A; Al-Hesayen, A; Waxman, M; Nattel, S; Nanthakumar, K,期刊:Circulation Research, 页码:1309-NIL_301 , 文章类型: Article,,卷期:2011年109-11]
- Rationale: Ventricular fibrillation (VF) leads to global ischemia. The modulation of ischemia-dependent pathways may alter the electrophysiological evolution of VF.Objective: We addressed the hypotheses that there is reg...
- Epigenetic Regulation of Endothelial Lineage Committed Genes in Pro-Angiogenic Hematopoietic and Endothelial Progenitor Cells
[作者:Ohtani, K; Vlachojannis, GJ; Koyanagi, M; Boeckel, JN; Urbich, C; Farcas, R; Bonig, H; Marquez, VE; Zeiher, AM; Dimmeler, S,期刊:Circulation Research, 页码:1219-NIL_71 , 文章类型: Article,,卷期:2011年109-11]
- Rationale: Proangiogenic hematopoietic and endothelial progenitor cells (EPCs) contribute to postnatal neovascularization, but the mechanisms regulating differentiation to the endothelial lineage are unclear.Objective: T...
- AMPK alpha 2 Deletion Exacerbates Neointima Formation by Upregulating Skp2 in Vascular Smooth Muscle Cells
[作者:Song, P; Wang, SX; He, CY; Wang, SB; Liang, B; Viollet, BN; Zou, MH,期刊:Circulation Research, 页码:1230-NIL_91 , 文章类型: Article,,卷期:2011年109-11]
- Rationale: Adenosine monophosphate-activated protein kinase (AMPK), a metabolic and redox sensor, is reported to suppress cell proliferation of nonmalignant and tumor cells. Whether AMPK alpha alters vascular neointima f...
- Histone Deacetylase 3 Regulates Smooth Muscle Differentiation in Neural Crest Cells and Development of the Cardiac Outflow Tract
[作者:Singh, N; Trivedi, CM; Lu, MM; Mullican, SE; Lazar, MA; Epstein, JA,期刊:Circulation Research, 页码:1240-NIL_110 , 文章类型: Article,,卷期:2011年109-11]
- Rationale: The development of the cardiac outflow tract (OFT) and great vessels is a complex process that involves coordinated regulation of multiple progenitor cell populations. Among these populations, neural crest cel...
- Splice Variant Specific Modulation of Ca(V)1.2 Calcium Channel by Galectin-1 Regulates Arterial Constriction
[作者:Wang, JJ; Thio, SSC; Yang, SSH; Yu, DJ; Yu, CY; Wong, YP; Liao, P; Li, SN; Soong, TW,期刊:Circulation Research, 页码:1250-NIL_135 , 文章类型: Article,,卷期:2011年109-11]
- Rationale: Ca(V)1.2 channels are essential for excitation-contraction coupling in the cardiovascular system, and alternative splicing optimizes its role. Galectin-1 (Gal-1) has been reported to regulate vascular smooth m...
- Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels
[作者:Mustafa, AK; Sikka, G; Gazi, SK; Steppan, J; Jung, SM; Bhunia, AK; Barodka, VM; Gazi, FK; Barrow, RK; Wang, R; Amzel, LM; Berkowitz, DE; Snyder, SH,期刊:Circulation Research, 页码:1259-NIL_169 , 文章类型: Article,,卷期:2011年109-11]
- Rationale: Nitric oxide, the classic endothelium-derived relaxing factor (EDRF), acts through cyclic GMP and calcium without notably affecting membrane potential. A major component of EDRF activity derives from hyperpola...
- Binding of CD40L to Mac-1's I-Domain Involves the EQLKKSKTL Motif and Mediates Leukocyte Recruitment and Atherosclerosis-But Does Not Affect Immunity and Thrombosis in Mice
[作者:Wolf, D; Hohmann, JD; Wiedemann, A; Bledzka, K; Blankenbach, H; Marchini, T; Gutte, K; Zeschky, K; Bassler, N; Hoppe, N; Rodriguez, AO; Herr, N; Hilgendorf, I; Stachon, P; Willecke, F; Duerschmied, D; von zur Muhlen, C; Soloviev, DA; Zhang, L; Bode, C; Plow, EF; Libby, P; Peter, K; Zirlik, A,期刊:Circulation Research, 页码:1269-NIL_202 , 文章类型: Article,,卷期:2011年109-11]
- Rationale: CD40L figures prominently in chronic inflammatory diseases such as atherosclerosis. However, since CD40L potently regulates immune function and hemostasis by interaction with CD40 receptor and the platelet int...
- Interleukin-10 Deficiency Impairs Bone Marrow-Derived Endothelial Progenitor Cell Survival and Function in Ischemic Myocardium
[作者:Krishnamurthy, P; Thal, M; Verma, S; Hoxha, E; Lambers, E; Ramirez, V; Qin, GJ; Losordo, D; Kishore, R,期刊:Circulation Research, 页码:1280-NIL_224 , 文章类型: Article,,卷期:2011年109-11]
- Rationale: Endothelial progenitor cell (EPC) survival and function in the injured myocardium is adversely influenced by hostile microenvironment such as ischemia, hypoxia, and inflammatory response, thereby compromising ...
- CD4(+) T Cells and Complement Independently Mediate Graft Ischemia in the Rejection of Mouse Orthotopic Tracheal Transplants
[作者:Khan, MA; Jiang, XG; Dhillon, G; Beilke, J; Holers, VM; Atkinson, C; Tomlinson, S; Nicolls, MR,期刊:Circulation Research, 页码:1290-NIL_256 , 文章类型: Article,,卷期:2011年109-11]
- Rationale: While microvascular injury is associated with chronic rejection, the cause of tissue ischemia during alloimmune injury is not yet elucidated.Objective: We investigated the contribution of T lymphocytes and com...
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