- Motility and Segregation of Hsp104-Associated Protein Aggregates in Budding Yeast
[作者：Zhou, CK; Slaughter, BD; Unruh, JR; Eldakak, A; Rubinstein, B; Li, R,期刊：Cell, 页码：1186-1196 , 文章类型： Article，,卷期：2011年147-5]
- During yeast cell division, aggregates of damaged proteins are segregated asymmetrically between the bud and the mother. It is thought that protein aggregates are cleared from the bud via actin cable-based retrograde tra...
- Kinesins Lead Aging Microtubules to Catastrophe
[作者：Akhmanova, A; Dogterom, M,期刊：Cell, 页码：966-968 , 文章类型： Editorial Material，,卷期：2011年147-5]
- The ability of growing microtubules to undergo catastrophes-abrupt switches from growth to shortening-is one of the key aspects of microtubule dynamics important for shaping cellular microtubule arrays. Gardner et al. sh...
- Contribution of I(h) to LTP, Place Cells, and Grid Cells
[作者：Mehta, MR,期刊：Cell, 页码：968-970 , 文章类型： Editorial Material，,卷期：2011年147-5]
- The brain's grid and place cells, which contribute to spatial representations of the external environment, are thought to be modulated by the hyperpolarization-activated cation current (I(h)). Giocomo et al. and Hussaini...
- A Genome Befitting a Monarch
[作者：Stensmyr, MC; Hansson, BS,期刊：Cell, 页码：970-972 , 文章类型： Editorial Material，,卷期：2011年147-5]
- The monarch butterfly is famous for its annual fall migration from eastern North America to central Mexico, but it has also been an important model for studies in long-distance migration. Now, Zhang et al. present the ge...
- Computer Vision in Cell Biology
[作者：Danuser, G,期刊：Cell, 页码：973-978 , 文章类型： Article，,卷期：2011年147-5]
- Computer vision refers to the theory and implementation of artificial systems that extract information from images to understand their content. Although computers are widely used by cell biologists for visualization and ...
- Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs
[作者：Fribourg, M; Moreno, JL; Holloway, T; Provasi, D; Baki, L; Mahajan, R; Park, G; Adney, SK; Hatcher, C; Eltit, JM; Ruta, JD; Albizu, L; Li, Z; Umali, A; Shim, J; Fabiato, A; MacKerell, AD; Brezina, V; Sealfon, SC; Filizola, M; Gonzalez-Maeso, J; Logothetis, DE,期刊：Cell, 页码：1011-1023 , 文章类型： Article，,卷期：2011年147-5]
- Atypical antipsychotic drugs, such as clozapine and risperidone, have a high affinity for the serotonin 5-HT(2A) G protein-coupled receptor (GPCR), the 2AR, which signals via a G(q) heterotrimeric G protein. The closely ...
- The Molecular Basis of CRL4(DDB2/CSA) Ubiquitin Ligase Architecture, Targeting, and Activation
[作者：Fischer, ES; Scrima, A; Bohm, K; Matsumoto, S; Lingaraju, GM; Faty, M; Yasuda, T; Cavadini, S; Wakasugi, M; Hanaoka, F; Iwai, S; Gut, H; Sugasawa, K; Thoma, NH,期刊：Cell, 页码：1024-1039 , 文章类型： Article，,卷期：2011年147-5]
- The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects UV-induced pyrimidine dimers in the genome and facilitat...
- Visualization of Eukaryotic DNA Mismatch Repair Reveals Distinct Recognition and Repair Intermediates
[作者：Hombauer, H; Campbell, CS; Smith, CE; Desai, A; Kolodner, RD,期刊：Cell, 页码：1040-1053 , 文章类型： Article，,卷期：2011年147-5]
- DNA mismatch repair (MMR) increases replication fidelity by eliminating mispaired bases resulting from replication errors. In Saccharomyces cerevisiae, mispairs are primarily detected by the Msh2-Msh6 complex and correct...
- Single-Molecule Imaging of Transcriptionally Coupled and Uncoupled Splicing
[作者：Vargas, DY; Shah, K; Batish, M; Levandoski, M; Sinha, S; Marras, SAE; Schedl, P; Tyagi, S,期刊：Cell, 页码：1054-1065 , 文章类型： Article，,卷期：2011年147-5]
- Introns are removed from pre-mRNAs during transcription while the pre-mRNA is still tethered to the gene locus via RNA polymerase. However, during alternative splicing, it is important that splicing be deferred until all...
- Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms
[作者：Piskounova, E; Polytarchou, C; Thornton, JE; LaPierre, RJ; Pothoulakis, C; Hagan, JP; Iliopoulos, D; Gregory, RI,期刊：Cell, 页码：1066-1079 , 文章类型： Article，,卷期：2011年147-5]
- Lin28A and Lin28B selectively block the expression of let-7 microRNAs and function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase (Zcchc11/TUT4) to let-7 precursors to block processing by Dicer in t...
- Molecular Basis for Interaction of let-7 MicroRNAs with Lin28
[作者：Nam, Y; Chen, C; Gregory, RI; Chou, JJ; Sliz, P,期刊：Cell, 页码：1080-1091 , 文章类型： Article，,卷期：2011年147-5]
- MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression. Among these, members of the let-7 miRNA family control many cell-fate determination genes to influence pluripotency, differentiation, an...
- TORC1 Regulates Endocytosis via Npr1-Mediated Phosphoinhibition of a Ubiquitin Ligase Adaptor
[作者：MacGurn, JA; Hsu, PC; Smolka, MB; Emr, SD,期刊：Cell, 页码：1104-1117 , 文章类型： Article，,卷期：2011年147-5]
- The TORC1 kinase signaling complex is a key determinant of cell growth that senses nutritional status and responds by coordinating diverse cellular processes including transcription, translation, and autophagy. Here, we ...
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