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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   Cancer Biomarkers: Closer to Delivering on their Promise [作者：Liotta, LA; Petricoin, E,期刊：Cancer Cell, 页码：279-280 , 文章类型： Editorial Material，,卷期：2011年20-3] Taguchi et al. describe, in this issue of Cancer Cell, a quantitative comparative biomarker discovery approach that integrates animal lung cancer models with validation in well-controlled human clinical study sets. This ... Ras, ROS and Proteotoxic Stress: A Delicate Balance [作者：Xu, WP; Trepel, J; Neckers, L,期刊：Cancer Cell, 页码：281-282 , 文章类型： Editorial Material，,卷期：2011年20-3] Ras-deregulated cells require reactive oxygen species for proliferation. They survive the resultant proteotoxic stress by maintaining sufficient levels of reduced glutathione and optimally functioning stress response mac... DePICTing p53 Activation: A New Nucleolar Link to Cancer [作者：Golomb, L; Oren, M,期刊：Cancer Cell, 页码：283-284 , 文章类型： Editorial Material，,卷期：2011年20-3] p53 activation by ribosomal biogenesis stress is important for tumor suppression. In the August issue of Nature Medicine, Sasaki et al. identify PICT1 as a regulator of this process. PICT1 sequesters ribosomal protein RP... Tissue States Provide Novel Insights into Attributes that Drive Metastasis [作者：Tisty, TD,期刊：Cancer Cell, 页码：285-286 , 文章类型： Editorial Material，,卷期：2011年20-3] Recently, in Nature Medicine, Schedin and colleagues define attributes within the involuting postpartum breast microenvironment that promote breast cancer metastasis. Cell invasiveness is controlled by a positive feedbac... Short Hairpin RNA Screen Reveals Bromodomain Proteins as Novel Targets in Acute Myeloid Leukemia [作者：Blobel, GA; Kalota, A; Sanchez, PV; Carroll, M,期刊：Cancer Cell, 页码：287-288 , 文章类型： Editorial Material，,卷期：2011年20-3] Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent... Lung Cancer Signatures in Plasma Based on Proteome Profiling of Mouse Tumor Models [作者：Taguchi, A; Politi, K; Pitteri, SJ; Lockwood, WW; Faca, VM; Kelly-Spratt, K; Wong, CH; Zhang, Q; Chin, A; Park, KS; Goodman, G; Gazdar, AF; Sage, J; Dinulescu, DM; Kucherlapati, R; DePinho, RA; Kemp, CJ; Varmus, HE; Hanash, SM,期刊：Cancer Cell, 页码：289-299 , 文章类型： Article，,卷期：2011年20-3] We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of lung cancer with profiles... Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung [作者：Granot, Z; Henke, E; Comen, EA; King, TA; Norton, L; Benezra, R,期刊：Cancer Cell, 页码：300-314 , 文章类型： Article，,卷期：2011年20-3] Primary tumors have been shown to prepare distal organs for later colonization of metastatic cells by stimulating organ-specific infiltration of bone marrow derived cells. Here we demonstrate that neutrophils accumulate ... The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels [作者：Tong, WH; Sourbier, C; Kovtunovych, G; Jeong, SY; Vira, M; Ghosh, M; Romero, VV; Sougrat, R; Vaulont, S; Viollet, B; Kim, YS; Lee, S; Trepe, J; Srinivasan, R; Bratslavsky, G; Yang, YF; Linehan, WM; Rouault, TA,期刊：Cancer Cell, 页码：315-327 , 文章类型： Article，,卷期：2011年20-3] Inactivation of the TCA cycle enzyme, fumarate hydratase (FH), drives a metabolic shift to aerobic glycolysis in FH-deficient kidney tumors and cell lines from patients with hereditary leiomyomatosis renal cell cancer (H... Asymmetry-Defective Oligodendrocyte Progenitors Are Glioma Precursors [作者：Sugiarto, S; Persson, AI; Munoz, EG; Waldhuber, M; Lamagna, C; Andor, N; Hanecker, P; Ayers-Ringler, J; Phillips, J; Siu, J; Lim, DA; Vandenberg, S; Stallcup, W; Berger, MS; Bergers, G; Weiss, WA; Petritsch, C,期刊：Cancer Cell, 页码：328-340 , 文章类型： Article，,卷期：2011年20-3] Postnatal oligodendrocyte progenitor cells (OPC) self-renew, generate mature oligodendrocytes, and are a cellular origin of oligodendrogliomas. We show that the proteoglycan NG2 segregates asymmetrically during mitosis t... BikDD Eliminates Breast Cancer Initiating Cells and Synergizes with Lapatinib for Breast Cancer Treatment [作者：Lang, JY; Hsu, JL; Meric-Bernstam, F; Chang, CJ; Wang, QF; Bao, Y; Yamaguchi, H; Xie, XM; Woodward, WA; Yu, DH; Hortobagyi, GN; Hung, MC,期刊：Cancer Cell, 页码：341-356 , 文章类型： Article，,卷期：2011年20-3] Breast cancer initiating cells (BCICs), which can fully recapitulate the tumor origin and are often resistant to chemo- and radiotherapy, are currently considered as a major obstacle for breast cancer treatment. Here, we... Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL [作者：Mali, RS; Ramdas, B; Ma, P; Shi, JJ; Munugalavadla, V; Sims, E; Wei, L; Vemula, S; Nabinger, SC; Goodwin, CB; Chan, RJ; Traina, F; Visconte, V; Tiu, RV; Lewis, TA; Stern, AM; Wen, Q; Crispino, JD; Boswell, HS; Kapur, R,期刊：Cancer Cell, 页码：357-369 , 文章类型： Article，,卷期：2011年20-3] We show constitutive activation of Rho kinase (ROCK) in cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL, which is dependent on PI3K and Rho GTPase. Genetic or pharmacologic inhibition of ROCK in oncogene-bearing ... Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids [作者：Roodhart, JML; Daenen, LGM; Stigter, ECA; Prins, HJ; Gerrits, J; Houthuijzen, JM; Gerritsen, MG; Schipper, HS; Backer, MJG; van Amersfoort, M; Vermaat, JSP; Moerer, P; Ishihara, K; Kalkhoven, E; Beijnen, JH; Derksen, PWB; Medema, RH; Martens, AC; Brenkman, AB; Voest, EE,期刊：Cancer Cell, 页码：370-383 , 文章类型： Article，,卷期：2011年20-3] The development of resistance to chemotherapy is a major obstacle for lasting effective treatment of cancer. Here, we demonstrate that endogenous mesenchymal stem cells (MSCs) become activated during treatment with plati... An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma [作者：Atkinson, JM; Shelat, AA; Carcaboso, AM; Kranenburg, TA; Arnold, LA; Boulos, N; Wright, K; Johnson, RA; Poppleton, H; Mohankumar, KM; Feau, C; Phoenix, T; Gibson, P; Zhu, LQ; Tong, YA; Eden, C; Ellison, DW; Priebe, W; Koul, D; Yung, WKA; Gajjar, A; Stewart, CF; Guy, RK; Gilbertson, RJ,期刊：Cancer Cell, 页码：384-399 , 文章类型： Article，,卷期：2011年20-3] Using a mouse model of ependymoma-a chemoresistant brain tumor-we combined multicell high-throughput screening (HTS), kinome-wide binding assays, and in vivo efficacy studies, to identify potential treatments with predic... Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors [作者：De Raedt, T; Walton, Z; Yecies, JL; Li, DA; Chen, YM; Malone, CF; Maertens, O; Jeong, SM; Bronson, RT; Lebleu, V; Kalluri, R; Normant, E; Haigis, MC; Manning, BD; Wong, KK; Macleod, KF; Cichowski, K,期刊：Cancer Cell, 页码：400-413 , 文章类型： Article，,卷期：2011年20-3] Ras-driven tumors are often refractory to conventional therapies. Here we identify a promising targeted therapeutic strategy for two Ras-driven cancers: Nf1-deficient malignancies and Kras/p53 mutant lung cancer. We show...